P1-449 Effect of stone dust on lung and lung function tests of stone quarry workers in Sri Lanka

Abstract

Introduction Previous studies have shown higher breast cancer incidence and mortality among Japanese Brazilians than Japanese. To clarify the difference in hormone levels among populations, we compared postmenopausal endogenous sex hormone levels among Japanese living in Japan, Japanese Brazilians living in São Paulo, and non-Japanese Brazilians living in São Paulo. Methods A cross-sectional study was conducted using a control group of case-control studies in Nagano, Japan and São Paulo, Brazil. Subjects were postmenopausal women aged over 55 years old who provided blood samples. We measured oestradiol, oestrone, androstenedione, dehydroepiandrosterone sulphate (DHEAS), testosterone and free testosterone by radioimmunoassay, bioavailable oestradiol by the ammonium sulphate precipitation method, and sex-hormone binding globulin (SHBG) by immunoradiometric assay. A total of 363 women were included for the present analyses: 185 Japanese, 44 Japanese Brazilians and 134 non-Japanese Brazilians. Results Japanese Brazilians had significantly higher levels of oestradiol, bioavailable oestradiol, oestrone, testosterone, and free testosterone, and lower SHBG levels than Japanese. Japanese Brazilians also had significantly higher levels of bioavailable oestradiol, oestrone, and DHEAS, and lower levels of SHBG and androstenedione than non-Japanese Brazilians. Levels of oestradiol, testosterone, and free testosterone, however, did not differ between Japanese Brazilians and non-Japanese Brazilians. These differences were observed even after adjustment for known breast cancer risk factors. Conclusions We found higher levels of oestrogens and androgens in Japanese Brazilians than in Japanese, and similar to or higher levels than in non-Japanese Brazilians. Our findings may help explain the increase in incidence and mortality of breast cancer among Japanese Brazilians. P1-447 HOW LONG DO PATIENTS IN THE UK GET TREATED FOR NON-SPECIFIC RESPIRATORY SYMPTOMS BY GENERAL PRACTITIONERS BEFORE THEY ARE DIAGNOSED WITH LUNG CANCER?doi:10.1136/jech.2011.142976g.37 B Iyen-Omofoman,* L Tata, R Hubbard. University of Nottingham, Nottingham, UK Introduction Most people with lung cancer in the UK are diagnosed late when curative treatment is no longer an option. This research aimed to determine the pattern of symptom reporting to GPs before lung cancer diagnosis to establish whether there is potential for developing a scoring system to allow cases to be diagnosed earlier.Methods We used data from The Health Improvement Network (THIN)dA computerised longitudinal primary care database. We identified 12 121 incident cases of lung cancer diagnosed between 2000 and 2009 and matched each case with up to four controls by age, sex and general practice (n¼48 216). Conditional logistic regression was carried out to estimate the ORs for symptoms 2 years before and 1 year before lung cancer diagnosis in cases compared to controls. Results A sharp increase in the consultation frequency among lung cancer cases was found for cough, haemoptysis, chest/shoulde...