P0493 : Selectin-targeting nanoparticles for immunomodulatory therapy of liver diseases

Bartneck, Matthias; Schlößer, Christopher Thorsten; Warzecha, Klaudia Theresa; Lammers, Twan; Moog, Kai E.; Kunz, Horst; Zentel, Rudolf; Barz, Matthias; Tacke, Frank

doi:10.1016/s0168-8278(15)30701-7

Cited by 1 publication

(1 citation statement)

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“…27 Scientists have aimed to produce materials that allow NPs to evade immune detection by illustrating surface features to hinder them from considering foreign objects mistakenly. 28 This would be achieved through the production of non-fouling coatings that impede the attachment of opsonin proteins to the native cells or the incorporation of self-marker proteins. Moreover, NPs could ease the immune-mediated clearance through transmitting signals at the nano-bio interface by introducing these properties to MPS-specific immune cells that are circulating.…”

Section: Introductionmentioning

confidence: 99%

Cell membrane biomimetic nanoparticles in drug delivery

Mohammad‐Rafiei,

Khojini,

Ghazvinian

et al. 2023

Biotech and App Biochem

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Despite the efficiency of nanoparticle (NP) therapy, in vivo investigations have shown that it does not perform as well as in vitro. In this case, NP confronts many defensive hurdles once they enter the body. The delivery of NP to sick tissue is inhibited by these immune‐mediated clearance mechanisms. Hence, using a cell membrane to hide NP for active distribution offers up a new path for focused treatment. These NPs are better able to reach the disease's target location, leading to enhanced therapeutic efficacy. In this emerging class of drug delivery vehicles, the inherent relation between the NPs and the biological components obtained from the human body was utilized, which mimic the properties and activities of native cells. This new technology has shown the viability of using biomimicry to evade immune system‐provided biological barriers, with an emphasis on restricting clearance from the body before reaching its intended target. Furthermore, by providing signaling cues and transplanted biological components that favorably change the intrinsic immune response at the disease site, the NPs would be capable interacting with immune cells regarding the biomimetic method. Thus, we aimed to provide a current landscape and future trends of biomimetic NPs in drug delivery.

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Section: Introductionmentioning

confidence: 99%