P021 Regional Recurrence Rate of Squamous Cell Carcinoma of the Anterior Nasal Cavity: A Systematic Review and Meta-analysis

Scurry, W. Cooper; Fedok, Fred G.; Goldenberg, D. M.; Lengerich, E. L.

doi:10.1001/archotol.132.8.870-b

Cited by 22 publications

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“…A meta-analysis of literature of 23 retrospective series of nasal cavity SCC, mostly predating modern radiographic and surgical techniques, has found 6% initial nodal involvement and 19% rate of subsequent nodal recurrence. Elective nodal treatment decreases this to a 4% nodal recurrence rate in this meta-analysis [4]. A key disadvantage of existing literature is its dependence on old staging systems predating modern methods of radiographic and surgical staging.…”

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confidence: 78%

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

et al. 2016

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Results: Among 1283 patients, 182 (14.2%) had nodal involvement at presentation (4-27% by site and local extension). T-stage alone was associated with higher rates of nodal involvement in maxillary sinus SCC, while higher T-stage and size >2 cm were associated with higher rates of nodal involvement in nasal cavity SCC on multivariable analysis. Facial nodes and cervical nodes at levels 1 and 2 have the highest rates of involvement in T4a nasal cavity SCC, whereas nodal levels 1, 2, and/or 3 have the highest rates of involvement in T2 or higher maxillary sinus SCC when compared with a clinical reference standard. Conclusion:In this population-based study, there are high rates of initial nodal involvement when stratified by local extent determined by T-stage in nasal cavity SCC and maxillary sinus SCC, and independently by size in nasal cavity SCC. Involvement of the facial and nodal levels 1-3 varies depending on site and local extent of tumor involvement. These observations may help guide treatment decision making in the inclusion of and extent of elective nodal treatment fields.

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confidence: 78%

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

et al. 2016

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“…Some previous reports with rather low incidence rates of regional metastases have favoured conservative management of the N0 neck [12]. In a recent meta-analysis by Scurry et al [13], the regional recurrence rate was 18.1%, and the authors advocated that patients with intranasal SCCs that demonstrate high-risk characteristics should be considered for elective treatment of the neck with either surgery or radiation therapy. The Danish group, however, does not recommend elective neck treatment for all patients [5].…”

Section: Discussionmentioning

confidence: 99%

A national series of 244 sinonasal cancers in Finland in 1990–2004

Koivunen

Mäkitie

Bäck

et al. 2011

Eur Arch Otorhinolaryngol

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Sinonasal cancer is still a somewhat controversial entity because most series are single-center studies. The aim of this study was to give more accurate and generalisable information about treatment of the neck and prognosis of sinonasal cancer. Retrospective, population-based, multicentre study. Altogether 244 patients diagnosed in 1990-2004 were evaluated. The 3- and 5-year disease-specific survival (DSS) rates after treatment with curative intent were 68 and 57%, respectively. Regional status at the time of the diagnosis (P < 0.001, log rank) and local recurrence (P = 0.02, log rank) during the follow-up had a statistically significant effect on DSS. Initially 13% of the patients were diagnosed with neck metastasis. The proportion of regional recurrences during the follow-up was 9%, but it did not have a statistically significant impact on DSS (P = 0.68, log rank). Histopathology had no statistically significant impact on survival in this material of 244 patients. In conclusion, routine elective neck treatment of all sinonasal cancer patients is not recommended, but the importance of the treatment of the primary location is emphasised.

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“…On the contrary, Scurry et al in their study supported the role of treating an N0 neck for squamous cell carcinomas. They stated the recurrence rate around 18.1 % [17].…”

Section: Discussionmentioning

confidence: 99%

“…Distant metastasis occurs in less than 2 % of all case [17,19]. On the contrary, distant failure alone or with local recurrence is more frequent and consists of 8-20 % of all recurrent diseases [20].…”

Section: Discussionmentioning

confidence: 99%

Management of Sinonasal Tumors: Prognostic Factors and Outcomes: A 10 Year Experience at a Tertiary Care Hospital

Kazi

Awan

Junaid

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Sinonasal malignancies are said to be a highly heterogeneous group of cancers, accounting for less than 1 % of all cancers and less than 3 % of all upper aerodigestive tract tumors. Originating from any histologic components of the sinonasal cavity, the histopathology of these tumors is diverse. Accordingly, treatment options vary, surgery being the mainstay in most of them. Recurrence rates differs with each histological type of tumor, dependent on various factors. In this article, we have tried to identify the prevalent characteristics of sinonasal malignancies and to outline the prognostic factors affecting the outcome. It is a retrospective study design with a total number of 102 patients. Patients diagnosed with sinonasal malignancies were included and any patient previously operated outside our institute or having received prior radiation or chemotherapy were excluded. The patients were selected over a period of 10 years, from 2000 to 2010. Data was analyzed using SPSS 17. Majority of the sinonasal tumors were squamous cell carcinomas involving the maxillary sinus. Locoregional recurrence was found to be more frequent in patients with positive neck nodes on final histopathology. Sinonasal malignancies are mostly squamous cell in variety and recurrence of these rare entities is dependent on the histological variety and the presence of positive neck nodes.Keywords Sinonasal malignancy Á Locoregional recurrence Á Squamous cell carcinoma Á Positive neck nodes Malignant lesions involving the sino-nasal tract account for 0.2-0.8 % overall and 3 % of all head and neck malignancies [1]. Approximately 55 % of these lesions are carcinomas with involvement of neck nodes in 7-15 % of the conditions. Treatment involves a wide variety of modalities, including surgery, radiotherapy, and chemotherapy, alone or in combination, however, there is still great controversy about the ideal treatment [1,2]. In 2003, the American Joint Committee on Cancer (AJCC) published the sixth edition of the sino-nasal tumor staging system [3]. This was in contrast to the fifthedition staging system of sino-nasal cancer in which the surgically resectable tumors and non-resectable tumors were all grouped together in the T4 stage [4]. As a result it was difficult to evaluate the results of surgery and a newer staging system was introduced.Despite these improvements, the fact is that there is no widely accepted staging system for tumors of the nasal cavity and ethmoid/sphenoid sinuses. The AJCC tumor stage classification only includes the maxillary sinus [5]. As obvious, this proves difficulties in tumors involving multiple sites in which the primary originating site is difficult to identify.We analysed retrospectively our 10 years experience of managing sino-nasal tumors, with a series of 63 patients.

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P021 Regional Recurrence Rate of Squamous Cell Carcinoma of the Anterior Nasal Cavity: A Systematic Review and Meta-analysis

Cited by 22 publications

References 0 publications

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

A national series of 244 sinonasal cancers in Finland in 1990–2004

Management of Sinonasal Tumors: Prognostic Factors and Outcomes: A 10 Year Experience at a Tertiary Care Hospital

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