P015 Association between the Interleukin 10 −1082G&gt;A Polymorphism and Coronary Heart Disease Risk in a Caucasian Population: A Meta-analysis

Wang, Y.; Zheng, Jianpeng; Liu, P.; Yu, Xue; Zhou, Deqi; Lin, Jiang; You, Yang; Zhou, Yuqiao

doi:10.1016/s0167-5273(11)70037-7

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“…Many scholars have carried out some research on RHD at the gene level, among them, the single nucleotide polymorphism of IL-10-1082G/A site is one of the key content of the research. Settin et al pointed out that: there is a certain correlation between the IL-10-1082G/A site single nucleotide polymorphism and the incidence of RHD [ 19 ] [ 20 – 22 ]. But H Chou [ 23 ], a Chinese scholar, found that there was no correlation between the IL-10-1082G/A gene polymorphism and the incidence of RHD in the Han population of Taiwan.…”

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confidence: 99%

Meta-analysis of the relationship between single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease

Dai

Lü

et al. 2018

Oncotarget

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BackgroundThe results showed that there was a certain correlation between the single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease, but there was no systematic study to verify this conclusion.AimsSystematic review of the association between single nucleotide polymorphism of IL-10-1082G/A locus and rheumatic heart disease.Materials and MethodsComputer retrieval PubMed, EMbase, Cochrane Library, CBM, CNKI, VIP and Data WanFang, the retrieval time limit from inception to June 2017. A case control study of single nucleotide polymorphisms and rheumatic heart disease in patients with rheumatic heart disease in the IL-10-1082G/A was collected. Two researchers independently screened the literature, extracted data and evaluated the risk of bias in the study, and using RevMan5.3 software for data analysis.ResultsA total of 3 case control studies were included, including 318 patients with rheumatic heart disease and 502 controls. Meta-analysis showed that there was no correlation between IL-10-1082G/A gene polymorphism and rheumatic heart disease [AA+AG VS GG: OR = 0.62, 95% CI (0.28, 1.39), P = 0.25; AA VS AG+GG: OR = 0.73, 95% CI (0.54, 1.00), P = 0.05; AA VS GG: OR = 0.70, 95% CI(0.47, 1.05), P = 0.08; AG VS GG: OR = 0.65, 95% CI (0.22, 1.92), P = 0.43; A VS G: OR = 0.87, 95% CI (0.71, 1.06), P = 0.17].ConclusionsWhen AA is a recessive gene, the single nucleotide polymorphism of IL-10-1082G/A is associated with the presence of rheumatic heart disease. Due to the limitations of the quantity and quality of the included literatures, the further research results were still needed.

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