P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised

Järemo, Petter; Milovanovic, Micha; Buller, Caroline; Nilsson, Staffan; Winblad, Bengt

doi:10.3109/00365513.2013.764572

Cited by 29 publications

(25 citation statements)

References 17 publications

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“…Levels of these molecules appear to be altered in some types of dementia, but their role is unclear. [27][28][29] ABO blood group also influences susceptibility to certain infectious diseases, including norovirus, cholera, and Helicobacter pylori infection, 30 through expression of the A and B antigens on gastrointestinal epithelium. It is possible that ABO type could alter CVD risk through its effects on nonblood tissues.…”

Section: Resultsmentioning

confidence: 99%

ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

et al. 2014

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Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15-2.90; and 1.24, 95% CI 1.10-1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119-165) compared with O (104 IU/dL; 95% CI 101-107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation 230% to 68%).Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels. There is a growing understanding that cardiovascular disease (CVD) and cognitive impairment share many common risk factors. Hypertension, 1,2 elevated cholesterol, 3 hyperglycemia, 2,4 and obesity 4,5 are all associated with longitudinal declines in cognitive function and dementia. Higher levels of the hemostatic markers von Willebrand factor (vWF), coagulation factor VIII (FVIII), and D-dimer have also been related to risk of cognitive impairment and dementia. [6][7][8][9] ABO blood group is associated with many forms of CVD, including coronary heart disease (CHD), stroke, and venous thromboembolism. [10][11][12] In general, individuals with blood group O have a reduced risk of CVD.13,14 Non-O blood types are associated with higher levels of vWF and FVIII, procoagulant proteins that circulate as a complex in blood, 11,12 because the ABO antigen affects clearance of vWF.15 Levels of both vWF and FVIII are associated with thrombosis, 16 and were recently linked to dementia risk. 17 A recent report demonstrating an association between blood type AB and stroke risk found that 60% of that association was mediated by differences in FVIII level. 18Although ABO blood group is a CVD risk factor, we are not aware of studies on its relationship with cognitive impairment. In this study, we examined the relationships among ABO group, FVIII, and incident cognitive impairment in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We hypothesized that blood group A, B, or AB would be associated with an increased risk of cognitive impairment relative to group O.

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Section: Resultsmentioning

confidence: 99%

ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

et al. 2014

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“…An elevated degree of platelet activation in AD patients has been reported by quantification of CD62P (P-selectin) surface expression, platelet aggregates, and platelet leukocytes complexes [75]. Results from another study contradict these findings as these show no difference in surface CD62P expression of unstimulated platelets but significantly lower levels in thrombin receptor activating peptide 6 (TRAP-6)-activated AD platelets [74]. However, this may be a sign of already exhausted platelets in vivo after sustained activation, reflected by the increase of sCD62P plasma levels [74].…”

Section: Reviewmentioning

confidence: 99%

“…Results from another study contradict these findings as these show no difference in surface CD62P expression of unstimulated platelets but significantly lower levels in thrombin receptor activating peptide 6 (TRAP-6)-activated AD platelets [74]. However, this may be a sign of already exhausted platelets in vivo after sustained activation, reflected by the increase of sCD62P plasma levels [74]. …”

Section: Reviewmentioning

confidence: 99%

Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers?

Veitinger

Varga

Guterres

et al. 2014

acta neuropathol commun

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Peripheral biomarkers play an indispensable role in quick and reliable diagnoses of any kind of disease. With the population ageing, the number of people suffering from age-related diseases is expected to rise dramatically over the coming decades. In particular, all types of cognitive deficits, such as Alzheimer’s disease, will increase. Alzheimer’s disease is characterised mainly by coexistence of amyloid plaques and neurofibrillary tangles in brain. Reliable identification of such molecular characteristics antemortem, however, is problematic due to restricted availability of appropriate sample material and definitive diagnosis is only possible postmortem. Currently, the best molecular biomarkers available for antemortem diagnosis originate from cerebrospinal fluid. Though, this is not convenient for routine diagnosis because of the required invasive lumbar puncture. As a consequence, there is a growing demand for additional peripheral biomarkers in a more readily accessible sample material. Blood platelets, due to shared biochemical properties with neurons, can constitute an attractive alternative as discussed here. This review summarises potential platelet Alzheimer’s disease biomarkers, their role, implication, and alteration in the disease. For easy comparison of their performance, the Hedge effect size was calculated whenever data were available.

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“…As shown in cardiovascular disease pathogenesis, high levels of von Willebrand factor (vWF), coagulation factor VIII (FVIII) are also associated with neurodegenerative disease pathogenesis. [9][10][11] Non -O blood groups have high VWF and FVIII levels than O-blood group. [12] Thus it can be said that the O-blood group has a protective effect from ischemic events and therefore neurodegeneration.…”

Section: Discussionmentioning

confidence: 99%

Association Between ABO Blood Group With Parkinson’s Disease

Bulur¹,

Korucu²

2019

Journal of Contemporary Medicine

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P arkinson's disease (PD) is a common neurodegenerative disorder that seen in adulthood. Most prevalent symptoms are resting tremor, rigidity, bradykinesia, gait disturbance, and postural abnormalities. The pathogenesis of Parkinson's disease cannot be clearly elucidated. Its proposed that deterioration of dopaminergic neural cells is a multifactorial process. At the present time intracellular-mitochondrial, extracellular and inflammatory/cytokine-related mechanisms are accused of the occurrence of this disease. [1,2] Blood groups first identified in 1900s. Currently there are 36 known blood group systems. Most clinically important are ABO and Rh. Blood group antigens are found on red blood cells, platelets, leukocytes, plasma proteins, certain tissues, and various cell surface enzymes, and also exist in soluble form in body secretions such as breast milk, seminal fluid, saliva, sweat, gastric secretions, urine, and amniotic fluid. [3] ABO blood groups were suggested to be related with several diseases. Disorders related with ABO blood group are infectious disease (cholera, Helicobacter pylori, and Echerichia coli), cardiovascular disease, malignancies and allergic status. [4-6] Introduction: Parkinson's disease is a common neurodegenerative disease that seen in adulthood. Most prevalent symptoms are resting tremor, rigidity, bradykinesia, gait disturbance, and postural abnormalities. Disorders related with ABO blood group are infectious disease (cholera, Helicobacter pylori, and Echerichia coli), cardiovascular disease, malignancies and allergic status. We objectived to elucidate the association between ABO blood group and Parkinson's disease. Methods: We investigated retrospectively the files of 264 adult patients who were diagnosed with Parkinson's disease and had blood type between January 2008 and December 2018 in neurology outpatient clinics included in the study. Results: Distribution of blood groups in patients as follows:

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P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised

Cited by 29 publications

References 17 publications

ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers?

Association Between ABO Blood Group With Parkinson’s Disease

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