2013
DOI: 10.3109/00365513.2013.764572
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P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised

Abstract: This study describes apparently paradoxical P-selectin reactions in moderate AD. While soluble P-selectin was higher in the disease group, membrane-attached P-selectin without agonist stimulation was no different between the disease and control groups. In contrast, AD was linked to lower platelet reactivity. The current findings encourage further research into this P-selectin paradox and its relevance for AD and, perhaps, other types of dementia as well.

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Cited by 29 publications
(25 citation statements)
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“…Levels of these molecules appear to be altered in some types of dementia, but their role is unclear. [27][28][29] ABO blood group also influences susceptibility to certain infectious diseases, including norovirus, cholera, and Helicobacter pylori infection, 30 through expression of the A and B antigens on gastrointestinal epithelium. It is possible that ABO type could alter CVD risk through its effects on nonblood tissues.…”
Section: Resultsmentioning
confidence: 99%
“…Levels of these molecules appear to be altered in some types of dementia, but their role is unclear. [27][28][29] ABO blood group also influences susceptibility to certain infectious diseases, including norovirus, cholera, and Helicobacter pylori infection, 30 through expression of the A and B antigens on gastrointestinal epithelium. It is possible that ABO type could alter CVD risk through its effects on nonblood tissues.…”
Section: Resultsmentioning
confidence: 99%
“…An elevated degree of platelet activation in AD patients has been reported by quantification of CD62P (P-selectin) surface expression, platelet aggregates, and platelet leukocytes complexes [75]. Results from another study contradict these findings as these show no difference in surface CD62P expression of unstimulated platelets but significantly lower levels in thrombin receptor activating peptide 6 (TRAP-6)-activated AD platelets [74]. However, this may be a sign of already exhausted platelets in vivo after sustained activation, reflected by the increase of sCD62P plasma levels [74].…”
Section: Reviewmentioning
confidence: 99%
“…Results from another study contradict these findings as these show no difference in surface CD62P expression of unstimulated platelets but significantly lower levels in thrombin receptor activating peptide 6 (TRAP-6)-activated AD platelets [74]. However, this may be a sign of already exhausted platelets in vivo after sustained activation, reflected by the increase of sCD62P plasma levels [74]. …”
Section: Reviewmentioning
confidence: 99%
“…As shown in cardiovascular disease pathogenesis, high levels of von Willebrand factor (vWF), coagulation factor VIII (FVIII) are also associated with neurodegenerative disease pathogenesis. [9][10][11] Non -O blood groups have high VWF and FVIII levels than O-blood group. [12] Thus it can be said that the O-blood group has a protective effect from ischemic events and therefore neurodegeneration.…”
Section: Discussionmentioning
confidence: 99%