P-Glycoprotein Expression on Patients with Acute Lymphoblastic Leukemia

Abstract

Abstract
 Objective: P-glycoprotein (P-gp) overexpression on neoplastic cells can deteriorate the therapeutic outcome on cancer patients.
 P-gp plays important role on drug efficacy and toxicity. This research aimed to measure P-gp expression on children with Acute
 Lymphoblastic Leukemia (ALL) on Sanglah Hospital, Denpasar. Method: Flowcytometry method was used to measure P-gp
 expression level on Bone Marrow samples from pediatric patients (0-12 years old) who were newly diagnosed with ALL in
 Sanglah Hospital. P-gp overexpression were based on the percentage of cell stained. Ten percent of P-gp expression were
 considered as the cut-off value of P-gp overexpression. Result: On this study, 11 samples were obtained with the range value of
 56-97% on P-gp expression. Conclusion: All 11 patients had P-gp overexpression.

Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells

“…The overexpression of the ATP-binding cassette (ABC) transporter proteins, especially P-glycoprotein (P-gp, ABCB1/MDR1), confer most prominent multidrug resistance [ 38 ]. Overexpression of P-gp has been reported on ALL patients [ 39 ]. Severe heart failure and pulmonary complications may be observed on MM patients after the targeted therapy of bortezomib [ 40 , 41 ].…”