P-cadherin expression and survival rate in oral squamous cell carcinoma:an immunohistochemical study

Muzio, Lorenzo Lo; Campisi, Giuseppina; Farina, Antonio; Rubini, Corrado; Pannone, Giuseppe; Serpico, Rosario; Laino, G; Lillo, Alfredo De

doi:10.1186/1471-2407-5-63

Cited by 33 publications

(26 citation statements)

References 60 publications

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“…34 However, aberrant expression has been observed in several malignant tumors, including adenocarcinomas of the cervix, ovarian cancer, oral squamous cell carcinomas and carcinomas of the breast. 19,22,23 Interestingly, also intrahepatic cholangiocarcinomas were shown to express P-cadherin (13/23 cases), whereas normal mucosa samples were consistently negative. 26 In our series, membranous expression of P-cadherin was found in only 9/127 (7%) evaluable normal mucosa samples but in more than 40% of adenomas and almost 60% of carcinomas, indicating a role in the carcinogenesis of ampullary tumors.…”

Section: Discussionmentioning

confidence: 99%

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Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

et al. 2009

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Carcinomas of the Vaterian system are rare and presumably arise from preexisting adenomas (adenomacarcinoma-sequence). Usually, biopsies are obtained to confirm and specify endoscopic findings, but differentiating reactive atypia from dysplasia or dysplasia from invasive carcinoma can sometimes be difficult or even impossible on morphological criteria alone. In case of invasive carcinoma, furthermore, the precise classification of carcinoma subtypes needs to be established since the distinct subtypes differ significantly in terms of clinical outcome. The cell adhesion proteins CD24, P-cadherin and S100A4 were shown to be expressed in several carcinomas and in dysplastic epithelium but only rarely in normal mucosa. We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater. Although the expression of the cell adhesion proteins did not differ between the carcinoma subtypes, marked differences between normal mucosa, adenoma and carcinoma samples were observed. All marker proteins were expressed in less than 7% of normal mucosa samples (S100A4 in only 1% of cases) and showed an increasing expression from adenoma to invasive carcinoma. Our findings suggest that P-cadherin and S100A4 are helpful in discriminating normal mucosa or reactive atypia from neoplastic lesions. CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma.

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Section: Discussionmentioning

confidence: 99%

“…[19][20][21][22][23][24] Also intraand extrahepatic cholangiocarcinomas have been reported to express CD24. [25][26][27] P-cadherin was found to be constantly upregulated in intrahepatic cholangiocarcinomas using cDNA microarray technique that was confirmed using immunohistochemistry.…”

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confidence: 99%

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

et al. 2009

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“…Physiologic P-cadherin expression is restricted to cytotrophoblastic cells in the placenta (placenta-cadherin), the basal layers of stratified epithelia in prostate and skin, and myoepithelial cells in the breast [16]. Up-regulation of P-cadherin has been shown in several cancers such as cervical adenocarcinoma [17], ovarian cancer [18], oral squamous cell carcinoma [19], and breast carcinoma [20,21].…”

Section: Introductionmentioning

confidence: 99%

Cell adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract

et al. 2010

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“…[92] ), MMPs and adhesion molecules (cadherins, catenins and selectins) [93][94][95] . The function of several molecules mentioned above, such as E-, N-and P-cadherins [94,95] , E-selectin, integrins (such as ␤ 1 integrin) and MMPs depend on a low molecular weight GTPase family, called Ras-homologous (Rho) proteins [96,97] . These proteins play a pivotal role in the regulation of numerous cellular functions associated with inflammation, malignant transformation and metastasis.…”

Section: The Effect Of Cell-cell Ratio and Interactionsmentioning

confidence: 99%

Role of Stromal Fibroblasts in Cancer: Promoting or Impeding?

Angeli¹,

Koumakis²,

Chen

et al. 2009

Tumor Biol

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The basement membrane, immune cells, capillaries, fibroblasts and extracellular matrix (ECM) constitute the tumour stroma, commonly referred to as the ‘reactive stroma’. The fibroblasts from the initial stages of a tumour, as the main constituents of the reactive stroma, present a different phenotype from the normal fibroblasts and play a crucial role in tumour progression. This review presents the differences between normal and tumour stromal fibroblasts and analyzes the molecular mechanisms (which involve growth factors, ECM components, matrix metalloproteinases, integrins and cell adhesion molecules) in the complex interactions between stromal fibroblasts and tumour cells. To date, several examples of heterotypic interactions between tumour stromal fibroblasts and tumour cells have supported the hypothesis that the tumour stroma promotes the growth of the tumour mass, as well as invasion and metastasis. However, it remains possible that the stroma acts essentially as a local modulator to impede tumorigenesis at an early stage and that the desmoplastic response is a host defence reaction designed to confine the developing tumour. The latter hypothesis has largely been neglected. The review aims to give a broader view on the role of stromal fibroblasts in tumour growth, invasion and metastasis.

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P-cadherin expression and survival rate in oral squamous cell carcinoma:an immunohistochemical study

Cited by 33 publications

References 60 publications

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

Cell adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract

Role of Stromal Fibroblasts in Cancer: Promoting or Impeding?

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