P.5.a.001 Effect of functional diet Polygala tenuifolia Willdenow extract (BT-11) on memory function of healthy general population

Jung, Hyungjin; Lee, J.Y.; Kim, S.H.; Shin, Keumchul; Lee, G.H.; Suh, Y.H.

doi:10.1016/s0924-977x(07)70813-1

Cited by 3 publications

(3 citation statements)

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“…At present, there have been many studies made on P. tenuifolia . Most of them have focused on the chemical structure and identification of saponin (Sakuma and Shoji 1981a,b), pharmacology (Chen et al 2004), clinical application (Jung et al 2007), content determination (Liu et al 2001; Yang and Sun 2007) as well as the root development and anatomy (Teng and Hu 2008). However, studies on the localization and accumulation of saponin in vegetative organs of P. tenuifolia have not been reported.…”

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confidence: 99%

Localization and Dynamic Change of Saponin in Vegetative Organs of Polygala tenuifolia

Hong-mei

Fang

Cai

et al. 2009

JIPB

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Anatomical, histochemical and phytochemical methods were used to investigate the structure, localization and dynamic changes of total saponin and senegenin of vegetative organs in Polygala tenuifolia Willd. Histochemical localization results showed that saponin accumulated mainly in parenchyma cells of vegetative organs. The phytochemical results also showed that the saponin accumulated in the vegetative organs of P. tenuifolia, with higher content in roots and lower content in the aerial parts that included stems and leaves. The saponin content and dry weight of the vegetative organs of P. tenuifolia had dynamic variance at the developmental stages and all reached the highest level in the post-fruit period. Hence, the roots and aerial parts should be gathered in August to make full use of the plant. As the root is the main medicinal organ of P. tenuifolia, the content of total saponin and senegenin of different aged and different parts of the root were determined. The content of total saponin and senegenin exhibited a sustained decreasing trend with increasing root age; therefore, the annual roots had high quality. The content of total saponin and senegenin in different parts of the root showed obvious variation. The content in the "skin areas" was much higher than that of xylem. The results offer a theoretical basis for determining the appropriate harvesting stage and a reasonable harvest of P. tenuifolia.

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confidence: 99%

Localization and Dynamic Change of Saponin in Vegetative Organs of Polygala tenuifolia

Hong-mei

Fang

Cai

et al. 2009

JIPB

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“…Based on the history of use, there is strong clinical support that Radix polygalae is memory improving since its efficacy has been demonstrated in elderly with mild cognitive decline [ 32 , 33 ]. There is suggestive evidence that Poria cocos , Radix glycyrrhizae , Radix Angelica sinensis , or Radix rehmanniae are memory improving, though modern clinical reports concerning the four herbs are absent yet.…”

Section: Discussionmentioning

confidence: 99%

“…Elderly with subjective memory impairment and mild cognitive impairment ascend with oral BT-11 at 300 mg/d for 4–8 weeks. Except for mild dyspepsia, no adverse events were reported [ 32 , 33 ].…”

Section: Evidence-based Efficacy Of Tcm Herbs On Cognitive Declinementioning

confidence: 99%

Traditional Chinese Medicine for Senile Dementia

Lin

Xiu

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese Medicine (TCM) has a 3000 years' history of human use. A literature survey addressing traditional evidence from human studies was done, with key result that top 10 TCM herb ingredients including Poria cocos, Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae were prioritized for highest potential benefit to dementia intervention, related to the highest frequency of use in 236 formulae collected from 29 ancient Pharmacopoeias, ancient formula books, or historical archives on ancient renowned TCM doctors, over the past 10 centuries. Based on the history of use, there was strong clinical support that Radix polygalae is memory improving. Pharmacological investigation also indicated that all the five ingredients mentioned above can elicit memory-improving effects in vivo and in vitro via multiple mechanisms of action, covering estrogen-like, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities. Furthermore, 11 active principles were identified, including sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid, Z-ligustilide, N-methyl-beta-carboline-3-carboxamide, coniferyl ferulate and 11-angeloylsenkyunolide F, and catalpol. It can be concluded that TCM has a potential for complementary and alternative role in treating senile dementia. The scientific evidence is being continuously mined to back up the traditional medical wisdom.

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Herbs and Dementia

Hügel

Jackson

2015

Diet and Nutrition in Dementia and Cognitive Decline

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P.5.a.001 Effect of functional diet Polygala tenuifolia Willdenow extract (BT-11) on memory function of healthy general population

Cited by 3 publications

References 0 publications

Localization and Dynamic Change of Saponin in Vegetative Organs of Polygala tenuifolia

Localization and Dynamic Change of Saponin in Vegetative Organs of Polygala tenuifolia

Traditional Chinese Medicine for Senile Dementia

Herbs and Dementia

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