P.32 Lipid infusion, lipid peroxidation and antioxidantstatus in adult patients on long-term home parenteral nutrition

A Randomized Controlled Trial on Parenteral Nutrition, Oxidative Stress, and Chronic Lung Diseases in Preterm Infants

“…Previous studies have uniformly shown that parenteral lipid emulsions convey an increased free radical stress (2,13,23). Lipid emulsions contain large amounts of polyunsaturated fatty acids (PUFA), which increase the susceptibility for peroxide formation (23). PUFA are essential constituents of biological membranes, but may also act as sacrificial antioxidants (24).…”

“…When TPN-lipid solution was protected from light, this difference disappeared. Previous studies have uniformly shown that parenteral lipid emulsions convey an increased free radical stress (2,13,23). Lipid emulsions contain large amounts of polyunsaturated fatty acids (PUFA), which increase the susceptibility for peroxide formation (23).…”

Advances in Intravenous Lipid Emulsions

“…In contrast to g -toc, which is excreted in the bile, a -toc is retained in the hepatocyte by a specific binding protein and repackaged into newly secreted endogenous lipoproteins. Increasing the a -toc content can efficiently counteract the risk of peroxidative damage associated with the use of PUFA-rich emulsions, as shown in preterm infants and in patients given parenteral nutrition at home [31]. It may also protect against peroxidation during manufacturing and storage [32] and in tubings when TPN is delivered without protection against light or during ultraviolet therapy [33].…”

Influence of Different Intravenous Lipid Emulsions on Hepatobiliary Dysfunction in a Rabbit Model

“…Lipid emulsions based on soybean oil with a high content of PUFA induce free oxygen radical formation and oxidative stress, which may render them more hepatotoxic (15,16). In adult patients, TPN with a lipid infusion rich in PUFA increased oxidative stress and lowered a-tocopherol concentration (17). In preterm infants, lipid peroxidation during TPN was associated with hepatocellular injury (18).…”