P-101 Tumor differentiation is a risk factor for lymph node metastasis in patients with gastric cancer

Baušys, Augustinas; Klimas, D.; Kilius, Alfredas; Pauža, K.; Rudinskaitė, Giedrė; Samalavičius, Narimantas Evaldas; Sinkevičius, Ž.; Sangaila, E.; Baušys, Rimantas

doi:10.1093/annonc/mdv233.101

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“…Lymph node status has great significance to the path of care chosen in early gastric cancer (EGC). It is not only important for proper treatment, but also for the prognosis of survival [ 1 , 2 ]. Additionally, confirmation of LNM is crucial when an endoscopic approach is considered, because such a procedure does not cure the disease in lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

Baušys

Vysniauskaite

et al. 2017

BMC Surg

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BackgroundCurrent risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in Western cohort patients from the Eastern European country - Lithuania.MethodsA total of 218 patients who underwent open gastrectomy for early gastric cancer were included in this retrospective study. After histolopathological examination, risk factors for lymph node metastasis were evaluated. Overall survival was evaluated and factors associated with long-term outcomes were analyzed.ResultsLymph node metastases were present in 19.7% of early gastric cancer cases. The rates were 5/99 (4.95%) for pT1a tumors and 38/119 (31.9%) for pT1b tumors. Submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation were identified as independent risk factors for lymph node metastasis. Submucosal tumor invasion and lymphovascular invasion were also associated with worse 5-year survival results.ConclusionOur study established submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation as risk factors for lymph node metastasis.

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Section: Introductionmentioning

confidence: 99%