P-1006 - The role of hypoxia in mental development and in the prevention and treatment of mental disorders: a review

Basovich, Simon N.

doi:10.1016/s0924-9338(12)75173-8

Cited by 18 publications

(22 citation statements)

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“…Other observations and explanations on health effects at higher altitudes include: a) protective effect against certain causes of death due to adaptation to decreased oxygen pressure [3]; b) protective effect against a number of disorders, including psychiatric disorders because of altitude hypoxia [15], which may be more effective if applied intermittently [16]; and c) risk factor for some conditions, as noted above [4][5]. Thus, effects of living at higher altitudes appear to: a) be a mixture of benefits and risks, and b) have different possible explanations.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, in the low level radiation range, cancer rates may actually decrease with increasing amounts of low level radiation, but obviously only to a point, where the radiation becomes high level, and, as previously noted, the cancer rates would be expected to increase with increasing high levels of radiation in a linear fashion. Others contend that radiation risks are linear, and that there is no threshold in the low level radiation range for which ionizing radiation can be considered safe (referred to as the linear non-threshold model) [14].Other observations and explanations on health effects at higher altitudes include: a) protective effect against certain causes of death due to adaptation to decreased oxygen pressure [3]; b) protective effect against a number of disorders, including psychiatric disorders because of altitude hypoxia [15], which may be more effective if applied intermittently [16]; and c) risk factor for some conditions, as noted above [4][5]. Thus, effects of living at higher altitudes appear to: a) be a mixture of benefits and risks, and b) have different possible explanations.…”

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confidence: 99%

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A method to study the possible effect of land elevation on cancer death rates in the U.S.

Hart¹

2014

Epidemiol Rep

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Background: Previous research revealed that cancer death rates tend to be lower in higher land elevation areas compared to lower land elevation areas. To further investigate this relationship, a novel method is used in the present study to identify low versus high elevation areas, with an accounting of air temperatures and smoking rates as other possible determinants of cancer. Methods: Counties in the United States that did not have overlapping land elevations (in feet above sea level, determined at the state level) were identified and categorized as having either a "low" or "high" elevation. States that were outliers for temperature and smoking rates were omitted. Using an ecological design, county cancer age-adjusted death rates (per 100,000 persons) for white persons during 2006-2010 were compared in low versus high land elevation counties in states having similar smoking rates and air temperature. Results: Cancer death rate for low land elevation counties (n=584 counties) was 189.6 (standard deviation [SD] 23.9) compared to the cancer death rate of 161.4 (SD 28.9) in high land elevation counties (n=162 counties), a difference that was statistically significant (p<0.0001) with a large effect size (of 1.12). Discussion: Limitations to the study include: a) its (ecological) design, where populations, rather than known individuals are studied; b) the assumption that land elevations remain essentially unchanged over time; c) the assumption that the selected states had sufficiently similar temperatures and smoking rates; d) only one race (whites) was studied for the cancer death rates; and e) only one outcome (cancer death rates) was studied. Conclusions: This study found lower cancer death rates in higher land elevation counties compared to lower land elevation counties, thus adding to the body of evidence on this topic. Ongoing research is indicated on the topic of land elevation-related health effects.Keywords: Altitude, environmental factors, cancer epidemiology, physiological adaptation, methodological study © 2014 John F. Hart; licensee Herbert Publications Ltd. This is an Open Access article distributed under the terms of Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0). This permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. IntroductionPrevious research has shown that cancer death rates tend to be lower in the U.S. for people living in higher land elevations [1]. This may be due to successful adaptation to stressors that accompany higher altitudes. These stressors include: a) low level (natural background) radiation, and b) decreased oxygen concentration.Natural background radiation (NBR) consists of terrestrial and cosmic sources. The variable of altitude pertains to the cosmic source of NBR. At higher altitudes (higher land elevations), there is less atmospheric filter, thus increasing the amount of the cosmic source of NBR. The successful adaptation to low level radiation has been termed radiat...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A method to study the possible effect of land elevation on cancer death rates in the U.S.

Hart¹

2014

Epidemiol Rep

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“…Some trials were performed by means of sojourns in the high mountains, by the use of hypobaric chamber and by the use of normobaric hypoxia (74). The results were negligible or insufficiently strong (for schizophrenia) or moderate (for depression).…”

Section: Iht and Its Clinical Applicationsmentioning

confidence: 99%

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

Basovich¹

2013

Biosci Trends

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“…87 Despite the fact that none of the DMPs reported in this study overlapped with genes reported to associate with gestational age, 87 it should be noted that the HumanMethyla-tion27 BeadChip array (Illumina) may be not robust enough to identify all genes associated with gestational age. In addition, birth complications can result in negative outcomes that increase the risk of mental disorders, 88 as well as impact the epigenome. 89 However, information on pregnancy and birth complications was unavailable for our cohort; thus, future studies will be necessary to assess the relation between birth complications, DNA methylation signatures and mental disorders.…”

Section: Discussionmentioning

confidence: 99%

Differential Dna Methylation at Birth Associated With Mental Disorder in Individuals With 22Q11.2 Deletion Syndrome

Starnawska

Hansen

Sparsø

et al. 2019

European Neuropsychopharmacology

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Individuals with 22q11.2 deletion syndrome (DS) have an increased risk of comorbid mental disorders including schizophrenia, attention deficit hyperactivity disorder, depression, as well as intellectual disability. Although most 22q11.2 deletion carriers have the long 3-Mb form of the hemizygous deletion, there remains a large variation in the development and progression of psychiatric disorders, which suggests that alternative factors contribute to the pathogenesis. In this study we investigated whether neonatal DNA methylation signatures in individuals with the 22q11.2 deletion associate with mental disorder later in life. DNA methylation was measured genome-wide from neonatal dried blood spots in a cohort of 164 individuals with 22q11.2DS, including 48 individuals diagnosed with a psychiatric disorder. Among several CpG sites with P-value o10 − 6 , we identified cg23546855 (P-value = 2.15 × 10 − 7) mapping to STK32C to be associated with a later psychiatric diagnosis. Pathway analysis of the top findings resulted in the identification of several Gene Ontology pathways to be significantly enriched (P-value o 0.05 after Benjamini-Hochberg correction); among them are the following: neurogenesis, neuron development, neuron projection development, astrocyte development, axonogenesis and axon guidance. In addition, we identified differentially methylated CpG sites in LRP2BP (P-value = 5.37 × 10 − 8) to be associated with intellectual disability (F70-79), in TOP1 (P-value = 1.86 × 10 − 7) with behavioral disorders (F90-98), in NOSIP (P-value = 5.12 × 10 − 8) with disorders of psychological development (F80-89) and in SEMA4B (P-value = 4.02 × 10 − 7) with schizophrenia spectrum disorders (F20-29). In conclusion, our study suggests an association of DNA methylation differences at birth with development of mental disorder later in life in 22q11.2DS individuals.

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P-1006 - The role of hypoxia in mental development and in the prevention and treatment of mental disorders: a review

Cited by 18 publications

References 0 publications

A method to study the possible effect of land elevation on cancer death rates in the U.S.

A method to study the possible effect of land elevation on cancer death rates in the U.S.

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

Differential Dna Methylation at Birth Associated With Mental Disorder in Individuals With 22Q11.2 Deletion Syndrome

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