P.1.195: Persistence of Endoscopic and Histological Inflammation After Attack of Colonic Diverticulitis as Risk Factors of Diverticulitis Recurrence

Randomised clinical trial: mesalazine and/or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease - a double-blind, randomised, placebo-controlled study

“…This reinforces the hypothesis that inflammation plays a key role in the pathogenesis of diverticular disease, and that only by controlling inflammation rather than controlling bacteria, we can prevent diverticular disease complica-tions. 10,30 On the contrary, a recent large trial of mesalazine (MMX 5-ASA) was reported negative in preventing relapses of diverticulitis. 31 However, the study focused on diverticulitis attacks rather than on abdominal symptoms.…”

The Pathophysiology of Colonic Diverticulosis: Inflammation versus Constipation?

“…Moreover, the characteristics of the abdominal pain (left lower-abdominal pain lasting for more than 24 h characterizes SUDD, diffuse and short-lived abdominal pain characterizes IBS) is likely the most effective clinical tool in discriminating between patients with SUDD and those having IBS [10,11]. Finally, persistence of symptoms following an episode of acute diverticulitis has been linked to several factors, ranging from significant attenuation in serotonin-transporter expression to persistence of low-grade inflammation [12][13][14]. These findings have been recently confirmed by Lahat et al [15], who found TNFα, IL6 and IL1β to be significantly higher in patients having symptom persistence following severe uncomplicated acute diverticulitis.…”

Enfermedad diverticular: mitos y realidades

“…Los pacientes con respuesta clínica favorable posterior a un episodio de DA no complicada, pero que mantienen valores elevados de CF, tendrían mayor probabilidad de recurrencia 48 .Colonoscopías realizadas posterior a una DA no complicada muestran la presencia de inflamación endoscópica e histológica en 27 y 37%, siendo considerados como predictores de recurrencia 49 .…”