Randomised clinical trial: mesalazine and/or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease - a double-blind, randomised, placebo-controlled study

Tursi, Antonio; Brandimarte, Giovanni; Elisei, Walter; Picchio, Marcello; Forti, Giacomo; Pianese, G; Rodinò, Stefano; D'Amico, Teresa; Saccà, N.; Portincasa, Piero; Capezzuto, E.; Lattanzio, Roberto; Spadaccini, A.; Fiorella, Serafina; Polimeni, F.; Polimeni, Nicola; Stoppino, V.; Stoppino, G.; Giorgetti, Gian Marco; Aiello, Fabio; Danese, Silvio

doi:10.1111/apt.12463

Cited by 135 publications

(122 citation statements)

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“…revised and scored, according to the DICA classification, the videos of 50 patients enrolled in the placebo arm of a previous double-blind placebo-controlled trial - Symptomatic Uncomplicated Diverticular Disease (SUDD) [14]. Those videos were available because one of the secondary aims of that study was to assess the influence of the severity and the extension of the diverticulosis on the recurrence of SUDD [14]. This placebo group was chosen because the patients did not take any treatment influencing the outcome of the disease.…”

Section: Methodsmentioning

confidence: 99%

Development and Validation of an Endoscopic Classification of Diverticular Disease of the Colon: The DICA Classification

Tursi¹,

Brandimarte

Mario

et al. 2014

Dig Dis

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Background: A validated endoscopic classification of diverticular disease (DD) of the colon is lacking at present. Our aim was to develop a simple endoscopic score of DD: the Diverticular Inflammation and Complication Assessment (DICA) score. Methods: The DICA score for DD resulted in the sum of the scores for the extension of diverticulosis, the number of diverticula per region, the presence and type of inflammation, and the presence and type of complications: DICA 1 (≤3), DICA 2 (4-7) and DICA 3 (>7). A comparison with abdominal pain and inflammatory marker expression was also performed. A total of 50 videos of DD patients were reassessed in order to investigate the predictive role of DICA on the outcome of the disease. Results: Overall agreement in using DICA was 0.847 (95% confidence interval, CI, 0.812-0.893): 0.878 (95% CI 0.832-0.895) for DICA 1, 0.765 (95% CI 0.735-0.786) for DICA 2 and 0.891 (95% CI 0.845-0.7923) for DICA 3. Intra-observer agreement (kappa) was 0.91 (95% CI 0.886-0.947). A significant correlation was found between the DICA score and C-reactive protein values (p = 0.0001), as well as between the median pain score and the DICA score (p = 0.0001). With respect to the 50 patients retrospectively reassessed, occurrence/recurrence of disease complications was recorded in 29 patients (58%): 10 (34.5%) were classified as DICA 1 and 19 (65.5%) as DICA 2 (p = 0.036). Conclusions: The DICA score is a simple, reproducible, validated and easy-to-use endoscopic scoring system for DD of the colon.

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Section: Methodsmentioning

confidence: 99%

Development and Validation of an Endoscopic Classification of Diverticular Disease of the Colon: The DICA Classification

Tursi¹,

Brandimarte

Mario

et al. 2014

Dig Dis

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“…Mesalazina como monoterapia tampoco logró diferencias significativas versus placebo, al evaluar la evolución de los síntomas digestivos 64 . Otros demostraron que la recurrencia con la asociación mesalazina-probióticos fue de 0% vs 13,7% en el grupo tratado con mesalazina, 14,5% en el tratado con Lactobacillus y 46% en el grupo placebo 65 . Dado que estudios han sugerido que la MI podría contribuir en la patogenia de la EDSNC, el uso de rifaximina ha sido evaluado en este escenario.…”

Section: Fármacosunclassified

Enfermedad diverticular: mitos y realidades

Fluxá

Quera

2017

Rev. méd. Chile

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“…wegen therapierefraktärer Colitis ulcerosa). Auch scheinen Probiotika ein Potenzial zur Reduktion von erneuten Diverticulitis-Episoden zu haben [21].…”

Section: Die Intestinale Mikrobiota Des Menschenunclassified

«Mikrobiota-Tuning» en vogue: Von der Ernährung über Probiotika bis zur fäkalen Mikrobiota-Transplantation

Biedermann

Rogler

Zeitz

2017

Schweiz Z Ganzheitsmed

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Randomised clinical trial: mesalazine and/or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease - a double-blind, randomised, placebo-controlled study

Abstract: SUMMARY BackgroundPlacebo-controlled studies in maintaining remission of symptomatic uncomplicated diverticular disease (SUDD) of the colon are lacking.

Cited by 135 publications

References 28 publications

Development and Validation of an Endoscopic Classification of Diverticular Disease of the Colon: The DICA Classification

Development and Validation of an Endoscopic Classification of Diverticular Disease of the Colon: The DICA Classification

Enfermedad diverticular: mitos y realidades

«Mikrobiota-Tuning» en vogue: Von der Ernährung über Probiotika bis zur fäkalen Mikrobiota-Transplantation

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