Ozone therapy for the treatment of recurrent pigmented villonodular synovitis of the knee

Oğuz, Hasan; Yıldızgören, Mustafa Turgut

doi:10.4103/2045-9912.296046

Cited by 1 publication

(1 citation statement)

References 2 publications

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“… 34 35 Besides, under normal oxygen conditions, the degradation of HIF-1α is promoted by prolyl hydroxylase domain-containing proteins with its transcriptional activity being inhibited by HIF-1α inhibitor protein (encoded by Hif-1α). 36 37 A typical feature of HIF-1α-dependent signaling is hypoxia, a condition in which tissue oxygen supply is in reduction. 37 38 Since hypoxic conditions are characteristic of the tumor microenvironment, the effects of both are inhibited.…”

Section: E Xperimental F Inding a Bout The R Oles Of H mentioning

confidence: 99%

Potential role of hydrogen sulfide in central nervous system tumors: a narrative review

Peng

Zhang

et al. 2022

Med Gas Res

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Central nervous system tumors are classified as diseases of special clinical significance with high disability and high mortality. In addition to cerebrovascular diseases and craniocerebral injuries, tumors are the most common diseases of the central nervous system. Hydrogen sulfide, the third endogenous gas signaling molecule discovered in humans besides nitric oxide and carbon monoxide, plays an important role in the pathophysiology of human diseases. It is reported that hydrogen sulfide not only exerts a wide range of biological effects, but also develops a certain relationship with tumor development and neovascularization. A variety of studies have shown that hydrogen sulfide acts as a vasodilator and angiogenetic factor to facilitate growth, proliferation, migration and invasion of cancer cells. In this review, the pathological mechanisms and the effect of hydrogen sulfide on the central nervous system tumors are introduced.

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