Ozone inhalation induces exacerbation of eosinophilic airway inflammation and Th2-skew immune response in a rat model of AR

Sun, Ninghui; Niu, Yue; Zhang, Ruxin; Huang, Yu; Wang, Jinchao; Qiu, Wenjia; Zhang, Xueyan; Han, Zhijin; Bao, Jing; Zhu, Huili; Duan, Yusen; Kan, Haidong

doi:10.1016/j.biopha.2021.111261

Cited by 10 publications

(5 citation statements)

References 22 publications

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“…In mice and rat models, ozone induced nasal type 2 immunity and aggravated eosinophilic inflammation. 29 , 30 In our study, we found that even with low exposure to O 3 , high symptoms already appeared in NAR patients, indicating that it was a relatively strong symptom inducer.…”

Section: Discussionsupporting

confidence: 51%

“…The risk was expressed as an odds ratio (OR) per one interquartile range (IQR, Q3 minus Q1) of each air pollutant. During the study period, the IQR levels of air pollutants were 2 (Q1-Q3;2-4) μg/m 3 for sulfur dioxide (SO 2 ), 16 (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) μg/m 3 for nitrogen dioxide (NO 2 ), 44 (60-104) μg/m 3 for ozone (O 3 ), 54 (32-86) μg/m 3 for particulate matter ≤10 μm in aerodynamic diameter (PM 10 ), 40(15-55) μg/m 3 for particulate matter ≤2.5 μm in aerodynamic diameter (PM 2.5 ), and 0.44 (0.4-0.84) μg/m 3 for carbon monoxide (CO).…”

Section: Statistical Analysesmentioning

confidence: 99%

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Impact of Air Pollutants and Pollen on the Severity of Nonallergic Rhinitis: A Data-Oriented Analysis

Huang¹,

Zhang²,

Wang³

et al. 2022

JAA

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Background Rhino-conjunctivitis symptoms are more severe in nonallergic rhinitis (NAR) patients during pollen season than in other seasons. Little is known about the role of pollen and air pollutants on the severity of NAR. Objective The aim of this study is to assess the cross-sectional effects of both pollen and air pollutants on NAR patients during the pollen and non-pollen seasons, and to further explore the possible relationship among these triggers. Methods A total of 2411 clinically diagnosed NAR outpatients from 2018 to 2019 were recruited for this study. The severity of NAR was measured using rhinoconjunctivitis symptom scores. Associations of daily exposure to pollen, PM 2.5 , PM 10 , NO 2 , SO 2 , CO, O 3 , and rhinoconjunctivitis symptom scores were evaluated using Logistic regression models. Distributed Lag Nonlinear models were used to explore single-day and accumulative Lag effects of environmental factors mentioned above. Results During the pollen season, pollen concentration, higher exposure levels of PM 10 , PM 2.5 , NO 2 , and SO 2 increased the severity of NAR group when compared with the low-moderate severity group. The high severity group was associated with lower exposure levels of O 3 . However, during non-pollen seasons, no significant association was found in air pollutant metrics, pollen concentration, and severity of NAR. The exposure-severity effects of pollen were different when different ambient pollutants were stratified. Conclusion Synergistic effect of pollen and air pollutants, including PM 2.5 , PM 10 , SO 2 , NO 2 , and O 3 , might be responsible for aggravating the symptoms of NAR patients during pollen seasons.

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Section: Discussionsupporting

confidence: 51%

Section: Statistical Analysesmentioning

confidence: 99%

Impact of Air Pollutants and Pollen on the Severity of Nonallergic Rhinitis: A Data-Oriented Analysis

Huang¹,

Zhang²,

Wang³

et al. 2022

JAA

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“…The mechanisms for respiratory effects of O 3 have not been sufficiently studied. Potential mechanisms reported by previous studies mainly focused on the Th2-dominated immune response [40]. Specifically, in rats with AR modeled in three steps of sensitization, challenge and ovalbumin [41], O 3 showed significant impacts on the elevation of cytokine proteins such as interleukin-5 (IL-5), IL-13 and eotaxin in nasal lavage fluid, revealing a Th2-dominant immune response.…”

Section: Potential Biological Mechanismsmentioning

confidence: 96%

Relationships between Long-Term Ozone Exposure and Allergic Rhinitis and Bronchitic Symptoms in Chinese Children

Zhou

Qian

McMillin

et al. 2021

Toxics

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Numerous studies have demonstrated that exposure to ambient ozone (O3) could have adverse effects on children’s respiratory health. However, previous studies mainly focused on asthma and wheezing. Evidence for allergic rhinitis and bronchitic symptoms (e.g., persistent cough and phlegm) associated with O3 is limited, and results from existing studies are inconsistent. This study included a total of 59,754 children from the seven northeastern cities study (SNEC), who were aged 2 to 17 years and from 94 kindergarten, elementary and middle schools. Information on doctor-diagnosed allergic rhinitis (AR), persistent cough, and persistent phlegm was collected during 2012–2013 using a standardized questionnaire developed by the American Thoracic Society (ATS). Information for potential confounders was also collected via questionnaire. Individuals’ exposure to ambient ozone (O3) during the four years before the investigation was estimated using a satellite-based random forest model. A higher level of O3 was significantly associated with increased risk of AR and bronchitic symptoms. After controlling for potential confounders, the OR (95% CI) were 1.13 (1.07–1.18), 1.10 (1.06–1.16), and 1.12 (1.05–1.20) for AR, persistent cough, and persistent phlegm, respectively, associated with each interquartile range (IQR) rise in O3 concentration. Interaction analyses showed stronger adverse effects of O3 on AR in children aged 7–17 years than those aged 2–6 years, while the adverse association of O3 with cough was more prominent in females and children aged 7–12 years than in males and children aged 2–6 and 13–17 years. This study showed that long-term exposure to ambient O3 was significantly associated with higher risk of AR and bronchitic symptoms in children, and the association varies across age and gender. Our findings contribute additional evidence for the importance of controlling O3 pollution and protecting children from O3 exposure.

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“…Our previous investigations revealed that O 3 exacerbates AR symptoms by modulating oxidative stress and immune imbalances. 4,5 Climate change is widely recognized as the biggest challenge and opportunity for global health in the 21st century. 6 However, previous studies have not assessed the relative impact of meteorological conditions on outpatient visits for patients with AR in Shanghai.…”

Section: Impact Of Air Pollutants and Meteorological Factors On Aller...mentioning

confidence: 99%

Impact of air pollutants and meteorological factors on allergic rhinitis outpatient visits in Shanghai, China

Na,

Yanan,

Lufang

et al. 2024

Allergy

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Ozone inhalation induces exacerbation of eosinophilic airway inflammation and Th2-skew immune response in a rat model of AR

Cited by 10 publications

References 22 publications

Impact of Air Pollutants and Pollen on the Severity of Nonallergic Rhinitis: A Data-Oriented Analysis

Impact of Air Pollutants and Pollen on the Severity of Nonallergic Rhinitis: A Data-Oriented Analysis

Relationships between Long-Term Ozone Exposure and Allergic Rhinitis and Bronchitic Symptoms in Chinese Children

Impact of air pollutants and meteorological factors on allergic rhinitis outpatient visits in Shanghai, China

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