Oyster peptide prevents the occurrence of exercise‐hypogonadal male condition by improving the function of pituitary gonadal axis in male rats

Abstract

This study evaluates the protective role of oyster peptide (OP) on the occurrence of Exercise‐Hypogonadal Male Condition. Male rats were given heavy‐load swimming training and / or OP was supplemented for 6 consecutive weeks. After heavy‐load training, sperm count, sperm viability and sperm motility in epididymis, testosterone in serum and testis, glutathione peroxidase (GSH‐px) and androgen receptor (AR) in testis and mating times were remarkably decreased, malondialdehyde (MDA), capture latency and mating latency were significantly increased, mRNA expression of steroidogenic acute regulatory (StAR) and P450 cholesterol side‐chain cleavage enzyme (P450scc) were obviously down‐regulated, but serum follicle‐stimulating hormone (FSH) and luteinising hormone (LH) were not statistically changed. Conversely, when OP was supplemented at heavy‐load training, sperm count, sperm viability and sperm motility in epididymis, serum FSH, LH, testosterone, GSH‐px, superoxide dismutase (SOD), testosterone, AR in testis and mating times were dramatically increased, while testicular MDA, capture latency and mating latency were significantly decreased, and mRNA expression of StAR, StARD7, P450scc and 3β‐hydroxysteroid dehydrogenase (3β‐HSD) were significantly up‐regulated. In conclusion, heavy‐load training causes testicular spermatogenic and steroidogenic disorders by enhancing the generation of reactive oxygen species (ROS), which can be protected by the co‐administration of OP by enhancing the function of pituitary gonad axis and lowering ROS generation.

Construction of a water‐in‐oil‐in‐water (W/O/W) double emulsion system based on oyster peptides and characterisation of freeze‐dried products

“…Compared with source proteins, peptides have significantly higher bioavailability due to their relatively low molecular weights (Wang & Selomulya, 2020), making them beneficial to the elderly, pregnant women, and athletes with special nutritional needs. A large number of studies have shown that oyster peptides obtained from oyster meat through enzymatic hydrolysis and refinement have anti‐cancer properties (Umayaparvathi et al ., 2014) can improve cognitive impairment via restoring glial cell dysfunction and neuronal injury (Zhu et al ., 2021), enhance antioxidant and aphrodisiac activities (Zhang et al ., 2019), and they also have anti‐wrinkle recovery photo‐aging properties (Bang et al ., 2020), anti‐oxidation properties (Wang et al ., 2014), and other biological activities (Jin et al ., 2021). Therefore, extensive and in‐depth research into various biologically active functions of oyster peptides supports the development and application of oyster peptides as marine functional food ingredients in the fields of nutrition and pharmaceuticals.…”

Bioactives From Marine Animals: Potential Benefits for Human Reproductive Health

“…Oyster peptide supplement could significantly support the function of the hypothalamus-pituitary gonad axis in male rates during heavy load training. This supplement can considerably reduce OS in testis by up-regulating steroidogenic enzyme expression to promote steroidogenesis and spermatogenesis (Jin et al, 2021b). In another study, oyster peptides and oyster powder were used to feed rats with reproductive dysfunction induced by cyclophosphamide.…”