Oxytocin inhibits food and fluid intake in rats

Arletti, Rossana; Benelli, Augusta; Bertolini, Alfio

doi:10.1016/0031-9384(90)90234-u

Cited by 216 publications

(162 citation statements)

References 52 publications

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“…68 -70 Indeed, intracerebroventricular injection of oxytocin inhibits water intake. 71,72 It has also been shown previously that oxytocin-induced AQP2/water channel mobilization occurs, in parallel with an oxytocininduced antidiuresis in Brattleboro rats. [73][74][75] However, we were unable to detect any significant change in plasma oxytocin levels in CT-treated rats.…”

Section: Discussionmentioning

confidence: 55%

Calcitonin Has a Vasopressin-like Effect on Aquaporin-2 Trafficking and Urinary Concentration

Bouley¹,

Lu²,

Nunes³

et al. 2011

Journal of the American Society of Nephrology

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The most common cause of hereditary nephrogenic diabetes insipidus is a nonfunctional vasopressin (VP) receptor type 2 (V2R). Calcitonin, another ligand of G-protein-coupled receptors, has a VP-like effect on electrolytes and water reabsorption, suggesting that it may affect AQP2 trafficking. Here, calcitonin increased intracellular cAMP and stimulated the membrane accumulation of AQP2 in LLC-PK1 cells. Pharmacologic inhibition of protein kinase A (PKA) and deficiency of a critical PKA phosphorylation site on AQP2 both prevented calcitonin-induced membrane accumulation of AQP2. Fluorescence assays showed that calcitonin led to a 70% increase in exocytosis and a 20% decrease in endocytosis of AQP2.Immunostaining of rat kidney slices demonstrated that calcitonin induced a significant redistribution of AQP2 to the apical membrane of principal cells in cortical collecting ducts and connecting segments but not in the inner stripe or inner medulla. Calcitonin-treated VP-deficient Brattleboro rats had a reduced urine flow and two-fold higher urine osmolality during the first 12 hours of treatment compared with control groups. Although this VP-like effect of calcitonin diminished over the following 72 hours, the tachyphylaxis was reversible. Taken together, these data show that calcitonin induces cAMP-dependent AQP2 trafficking in cortical collecting and connecting tubules in parallel with an increase in urine concentration. This suggests that calcitonin has a potential therapeutic use in nephrogenic diabetes insipidus.

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Section: Discussionmentioning

confidence: 55%

Calcitonin Has a Vasopressin-like Effect on Aquaporin-2 Trafficking and Urinary Concentration

Bouley¹,

Lu²,

Nunes³

et al. 2011

Journal of the American Society of Nephrology

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“…However, ICV administration of NPFF has been shown to activate oxytocin neurons in the PVN (Jhamandas & MacTavish 2003). Therefore, the anorexic effects of ICV NPFF may involve oxytocin, as this peptide can also reduce feeding when administered centrally (Arletti et al 1990, Olson et al 1991.…”

Section: Npff Familymentioning

confidence: 99%

The role of RFamide peptides in feeding

Bechtold

Luckman

2007

Journal of Endocrinology

115

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In the three decades since FMRFamide was isolated from the clam Macrocallista nimbosa, the list of RFamide peptides has been steadily growing. These peptides occur widely across the animal kingdom, including five groups of RFamide peptides identified in mammals. Although there is tremendous diversity in structure and biological activity in the RFamides, the involvement of these peptides in the regulation of energy balance and feeding behaviour appears consistently through evolution. Even so, questions remain as to whether feedingrelated actions represent a primary function of the RFamides, especially within mammals. However, as we will discuss here, the study of RFamide function is rapidly expanding and with it so is our understanding of how these peptides can influence food intake directly as well as related aspects of feeding behaviour and energy expenditure.

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“…Aside from their involvement in the development of taste aversion, OT and VP have been proposed as part of central satiety mechanisms (7,23). Thus an observed increase in activation of PVN OT/VP neurons after anorexia-but not aversion-inducing PHI treatments allows us to propose a hypothesis that the OT/VP system may mediate the inhibitory effect of PHI on food consumption.…”

Section: Discussionmentioning

confidence: 97%

“…Another interesting issue related to anorexigenic properties of PHI and VIP, as members of the same peptide group, is that according to the initial evidence, both peripheral and central pools of these peptides appear to modulate consumption (7,14,16,22,23,29,36,47). It has been shown that some peptides belonging to the PACAP/glucagon family are capable of crossing the blood-brain barrier (see, e.g., Ref.…”

Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that indirect evidence points also to the likely role of the central pool of PHI in feeding control. It has been reported that central injection of this peptide activates hypothalamic oxytocin (OT) and vasopressin (VP) systems (5,10,34); importantly, OT and VP are thought to inhibit food intake through satiety-and aversion-related mechanisms (7,23).…”

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confidence: 99%

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Effect of peptide histidine isoleucine on consummatory behavior in rats

Olszewski

Wirth

Shaw

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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. Effect of peptide histidine isoleucine on consummatory behavior in rats. Am J Physiol Regul Integr Comp Physiol 284: R1445-R1453, 2003. First published February 20, 2003 10.1152/ajpregu.00554.2002-Peptide histidine isoleucine (PHI) and VIP are derived from the same precursor. While central VIP decreases food intake, potential effects of PHI on feeding have not been studied. In the current study, we found that PHI administered intracerebroventricularly (ICV) or into the hypothalamic paraventricular nucleus (PVN) or central nucleus of the amygdala (CeA) decreased food consumption in overnight-deprived rats. The magnitude of an anorexigenic response to PHI differed depending on the injection route: ICV-infused peptide evoked the most potent effect. We determined that that only PVN-and CeA-injected PHI did not have aversive consequences. In addition, we infused anorexigenic doses of PHI via the same routes and assessed Fos immunoreactivity of PVN oxytocin (OT) and vasopressin (VP) neurons using double immunohistochemistry. OT and VP are thought to promote feeding termination. PHI increased the percentage of Fos-positive OT neurons regardless of the injection route. PVN-and ICV-infused PHI induced activation of VP cells. We conclude that central PHI has an inhibitory influence on food intake in rats. The PVN, with OT and VP neurons, and CeA may be involved in the mediation of anorexigenic effects of PHI. conditioned taste aversion; oxytocin; vasopressin; paraventricular nucleus of the hypothalamus; amygdala PEPTIDE HISTIDINE ISOLEUCINE (PHI) belongs to the pituitary adenylate cyclase-activating polypeptide (PACAP)/ glucagon family derived from a common precursor protein, prepro-VIP. PHI, VIP, peptide histidine valine (PHV), and peptide histidine methionine, among others, are processed from this precursor molecule. Prepro-VIPrelated peptides, including PHI, share a structural homology, as well as a certain degree of functional similarities, e.g., by having a stimulatory effect on the release and/or synthesis of glucagon (8), prolactin (20,28,40), and melatonin (21, 37, 49), and by affecting circadian rhythmicity (2, 3), heart rate (38), vasomotor functions (15, 19), and activation of the hypothalamic-pituitaryadrenal (HPA) axis (4, 6).PHI is widespread throughout the central and peripheral nervous systems (12). The presence of this peptide has been demonstrated in numerous central regions, where PHI often colocalizes in neurons with other products of prepro-VIP (13). Interestingly, PHIcontaining neuronal elements are encompassed in several brain sites involved in the regulation of consummatory behavior, including the hypothalamic paraventricular (PVN), supraoptic (SON), and arcuate (ARC) nuclei, central nucleus of the amygdala (CeA), and bed nucleus of the stria terminalis (17, 30).The abundance of receptors for PHI in these feedingrelated areas has also been confirmed. There are two well-described subtypes of receptors for PHI, termed VIP1 and VIP2 (18,24,45). These receptors do not seem to be selective to PHI al...

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Oxytocin inhibits food and fluid intake in rats

Cited by 216 publications

References 52 publications

Calcitonin Has a Vasopressin-like Effect on Aquaporin-2 Trafficking and Urinary Concentration

Calcitonin Has a Vasopressin-like Effect on Aquaporin-2 Trafficking and Urinary Concentration

The role of RFamide peptides in feeding

Effect of peptide histidine isoleucine on consummatory behavior in rats

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