Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men

Coiro, V.; Volpi, R.; Stella, Adriano; Cataldo, Simona; Chiodera, P.

doi:10.1016/j.npep.2010.12.007

Cited by 11 publications

(11 citation statements)

References 31 publications

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“…On the other hand, the relationship between the OT and ghrelin systems has not been fully elucidated. While it has been demonstrated that OT could not inhibit the stimulatory effect of AG on GH, PRL, and ACTH release in healthy subjects (Coiro et al 2011), it might influence the effect of AG on NPY secretion (Coiro et al 2008), which suggests the existence of an intricate relationship between both neuropeptide systems.…”

Section: Posterior Pituitary Hormonesmentioning

confidence: 92%

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete

Rincón-Fernández

Villa-Osaba

et al. 2013

Journal of Endocrinology

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Ghrelin is a 28-amino acid acylated hormone, highly expressed in the stomach, which binds to its cognate receptor (GHSR1a) to regulate a plethora of relevant biological processes, including food intake, energy balance, hormonal secretions, learning, inflammation, etc. However, ghrelin is, in fact, the most notorious component of a complex, intricate regulatory system comprised of a growing number of alternative peptides (e.g. obestatin, unacylated ghrelin, and In1-ghrelin, etc.), known (GHSRs) and, necessarily unknown receptors, as well as modifying enzymes (e.g. ghrelin-O-acyl-transferase), which interact among them as well as with other regulatory systems in order to tightly modulate key (patho)-physiological processes. This multiplicity of functions and versatility of the ghrelin system arise from a dual, genetic and functional, complexity. Importantly, a growing body of evidence suggests that dysregulation in some of the components of the ghrelin system can lead to or influence the development and/or progression of highly concerning pathologies such as endocrine-related tumors, inflammatory/cardiovascular diseases, and neurodegeneration, wherein these altered components could be used as diagnostic, prognostic, or therapeutic targets. In this context, the aim of this review is to integrate and comprehensively analyze the multiple components and functions of the ghrelin system described to date in order to define and understand its biological and (patho)-physiological significance.

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Section: Posterior Pituitary Hormonesmentioning

confidence: 92%

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete

Rincón-Fernández

Villa-Osaba

et al. 2013

Journal of Endocrinology

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“…Oxytocin does not modify GH, ACTH, cortisol or prolactin responses to ghrelin in normal men (Coiro et al 2011) but does seem to attenuate stress-induced hypothalamic-pituitary-adrenal (HPA) activity and anxiety behaviors (Ochedalski et al 2007). Interestingly, central oxytocin attenuates both the stressinduced neuroendocrine and molecular responses of the HPA axis and the oxytocin-sensitive forebrain stress circuit, which comprises the dorsal hippocampus, the ventrolateral septum, and the PVN (Windle et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…AVP and oxytocin are both peptides consisting of nine amino acids and differing by just two amino acids (Li et al 2007). To date, there have been a few papers regarding the various effects of AVP and oxytocin on hormone secretions as regulated by their own receptors (Liu et al 1994;Engler et al 1999;Katoh et al 2004aKatoh et al , 2005Coiro et al 2011). To date, there have been a few papers regarding the various effects of AVP and oxytocin on hormone secretions as regulated by their own receptors (Liu et al 1994;Engler et al 1999;Katoh et al 2004aKatoh et al , 2005Coiro et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The hypothalamic-neurohypophysial system plays a fundamental role in the maintenance of body fluid homeostasis by secreting AVP and oxytocin in response to a variety of signals, including osmotic and nonosmotic stimuli. To date, there have been a few papers regarding the various effects of AVP and oxytocin on hormone secretions as regulated by their own receptors (Liu et al 1994;Engler et al 1999;Katoh et al 2004aKatoh et al , 2005Coiro et al 2011). The functions of AVP include regulation of body fluid homeostasis, hormone secretion from the anterior pituitary gland, and cardiovascular control (McEwen 2004).…”

Section: Introductionmentioning

confidence: 99%

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Actions of intravenous injections of AVP and oxytocin on plasma ACTH, GH, insulin and glucagon concentrations in goats

Roh

Koiwa

Sato

et al. 2013

Animal Science Journal

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This study was conducted to investigate the arginine-vasopressin (AVP)- and oxytocin-induced changes in plasma adrenocorticotropic hormone (ACTH), growth hormone (GH), insulin and glucagon levels and their metabolite concentrations in goats. In this study, five goats were intravenously injected with either AVP (0.3 nmol/kg body weight (BW)) or oxytocin (0.7 IU/kg BW). AVP injection significantly increased ACTH and GH secretions compared to controls, although insulin and glucagon concentrations were not altered. The incremental areas (ICAs) of the ACTH and GH concentrations were higher in the AVP group than in the saline group. Oxytocin injections increased insulin and glucagon secretions, while ACTH level was not altered. GH levels became elevated 30 min after the oxytocin injection. The ICAs of insulin and glucagon after oxytocin was injected were higher than those of the control. Results indicate that AVP is a potent stimulant of ACTH and GH secretions, while oxytocin uses different pathways to regulate insulin and glucagon secretions in goats.

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“…35 In high doses, ghrelin may also stimulate prolactin, corticotropin and cortisol secretion in humans. 36 Orexigenic Effect (Appetite-stimulating Effect)…”

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confidence: 99%

Ghrelin – Physiological Functions and Regulation

Abdalla

2015

European Endocrinology

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Ghrelin is an orexigenic peptide predominantly secreted from the stomach and stimulates appetite and growth hormone (GH) release.Studies have provided evidence that ghrelin exercises a wide range of functions, including regulation of food intake and energy metabolism, modulation of cardiovascular function, stimulation of osteoblast proliferation and bone formation and stimulation of neurogenesis and myogenesis. In the gastrointestinal system, ghrelin affects multiple functions, including secretion of gastric acid, gastric motility and pancreatic protein output. Most of these functions have been attributed to the actions of acylated ghrelin. The balance among its secretion rate, degradation rate and clearance rate determines the circulating level of ghrelin. This review explains what ghrelin is, its physiological functions and the factors that influence its level. KeywordsGhrelin, food intake, obesity, lipolysis, ghrelin receptors, regulation Disclosure: Mona Mohamed Ibrahim Abdalla has no conflicts of interest to declare. Acknowledgement:A note of appreciation to Research Management Centre of MAHSA University, Malaysia for funding publication of this article.

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Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men

Cited by 11 publications

References 31 publications

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Actions of intravenous injections of AVP and oxytocin on plasma ACTH, GH, insulin and glucagon concentrations in goats

Ghrelin – Physiological Functions and Regulation

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