Actions of intravenous injections of <scp>AVP</scp> and oxytocin on plasma <scp>ACTH</scp>, <scp>GH</scp>, insulin and glucagon concentrations in goats

Roh, Sang Gun; Koiwa, Kohta; Sato, Kei; Ohtani, Yoshihisa; Takahashi, Teruyuki; Katoh, K.

doi:10.1111/asj.12142

Cited by 6 publications

(5 citation statements)

References 38 publications

(91 reference statements)

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“…Levels of β‐hydroxybutyrate (BHBA) were determined via UV and colorimetric methods using F‐kits (R‐Biopharm AG, Darmstadt, Germany). Concentrations of GH, insulin, and IGF‐1 were analyzed according to the methods of our previously published studies (Roh et al., ; Suzuki et al., ). The detection limits of growth hormone (GH), insulin, and insulin‐like growth factor 1 (IGF‐I) were 0.03 ng, 0.031 ng, and 1.86 pg in tube, respectively.…”

Section: Methodsmentioning

confidence: 99%

Effects of butyrate supplementation in antibiotic‐free milk replacer and starter on growth performance in suckling calves

Roh

Kimura

Sakamoto³

et al. 2018

Animal Science Journal

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The aim of this study was to evaluate butyrate supplementation of antibiotic-free milk replacer and starter on growth performance in male Holstein calves. Twenty-nine calves were divided into two groups. Group C (n = 13) was fed antibiotic-free milk replacer without supplementation, and Group B (n = 16) was fed antibiotic-free milk replacer supplemented with butyrate (1.6 % DM of Gustor BP70 ). Starter in Group B contained 0.3 % DM of Gustor BP70 . The intake of milk replacer was lower in group B than in C (p = 0.07 for the treatment x week interaction). Body weight (BW) and heart girth (HG) in group B was higher than in C during the experimental period (p = 0.07 and 0.01 for the treatment × week interaction, respectively). The duration of the weaning period in group B was shorter than in group C (p = 0.02). β-hydroxybutyrate (BHBA) was higher in group B than in C (p = 0.04). Insulin like growth factor-1 (IGF-1) concentrations tended to be higher in group B than in C (p = 0.07 for treatment × week interaction). Our results show that butyrate supplementation in antibiotic-free milk replacer and starter exerted positive effects on growth performance in suckling calves.

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Section: Methodsmentioning

confidence: 99%

Effects of butyrate supplementation in antibiotic‐free milk replacer and starter on growth performance in suckling calves

Roh

Kimura

Sakamoto³

et al. 2018

Animal Science Journal

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“…Intranasal application in dogs increases glucagon and insulin secretion (37), and this is probably mediated peripherally as intravenous oxytocin has a similar effect in goats (38) and dogs (39). In rats, oxytocin receptors are expressed by glucagon-and insulin-secreting cells in the pancreas (40), and direct stimulation of glucagon release has been characterised in vitro (41).…”

Section: Peripheral Targets For Oxytocinmentioning

confidence: 99%

Intranasal Oxytocin: Myths and Delusions

Leng

Ludwig

2016

Biological Psychiatry

519

475

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Despite widespread reports that intranasal application of oxytocin has a variety of behavioral effects, very little of the huge amounts applied intranasally appears to reach the cerebrospinal fluid. However, peripheral concentrations are increased to supraphysiologic levels, with likely effects on diverse targets including the gastrointestinal tract, heart, and reproductive tract. The wish to believe in the effectiveness of intranasal oxytocin appears to be widespread and needs to be guarded against with scepticism and rigor. Preregistering trials, declaring primary and secondary outcomes in advance, specifying the statistical methods to be applied, and making all data openly available should minimize problems of publication bias and questionable post hoc analyses. Effects of intranasal oxytocin also need proper dose-response studies, and such studies need to include control subjects for peripheral effects, by administering oxytocin peripherally and by blocking peripheral actions with antagonists. Reports in the literature of oxytocin measurements include many that have been made with discredited methodology. Claims that peripheral measurements of oxytocin reflect central release are questionable at best.

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“…3 Animal studies have shown that direct injection of oxytocin centrally suppressed the desire for food consumption and influenced glucose metabolism. [4][5][6] Knock-out OXT-or OXTR-gene mice developed hyperphagia and obesity phenotypes. 7,8 In addition, a feedback of oxytocin secretion can be stimulated by changes in glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

<p>The <em>OXTR</em> Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects</p>

Chang

Hung

et al. 2019

DMSO

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Objective: Previous animal studies have shown that the oxytocin system might affect glucose homeostasis through the hypothalamus-pituitary-adrenal (HPA) axis and peripheral organs. Moreover, whether the effect is stratified by the polymorphism of oxytocin receptor gene (OXTR) remains unclear. Methods: In this study, we recruited 89 non-diabetic participants. Their plasma oxytocin and serum insulin profiles were obtained, and the polymorphism of OXTR rs53576 was genotyped. Results: There were significant correlations between the oxytocin level and fasting glucose level (r =-0.29, P <0.01), insulin level (r =-0.26, P = 0.01), and homeostasis model assessment-estimated insulin resistance (HOMA-IR) (r =-0.25, P = 0.01), when adjusted for age, gender, and body mass index (BMI). When further considering the stratification effects of OXTR variation, we found that the oxytocin level was significantly correlated with the fasting glucose level (r =-0.25, P = 0.04), insulin level (r =-0.35, P = 0.03), and HOMA-IR (r =-0.35, P < 0.01) in subjects with the OXTR A allele (n = 75) after adjustment for age, gender, and BMI. In addition, the oxytocin level in those with the GG genotype of OXTR was significantly negatively correlated with the leptin level (n = 14, r =-0.66, P = 0.02). Conclusion: The results demonstrated that the polymorphism of OXTR plays an important role in individual differences in the correlation of oxytocin and glucose homeostasis in nondiabetic subjects.

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Actions of intravenous injections of AVP and oxytocin on plasma ACTH, GH, insulin and glucagon concentrations in goats

Cited by 6 publications

References 38 publications

Effects of butyrate supplementation in antibiotic‐free milk replacer and starter on growth performance in suckling calves

Effects of butyrate supplementation in antibiotic‐free milk replacer and starter on growth performance in suckling calves

Intranasal Oxytocin: Myths and Delusions

<p>The <em>OXTR</em> Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects</p>

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