Oxytetracycline Residues in Giant Freshwater Prawn (<i>Macrobrachium rosenbergii</i>)

Brillantes, Supapun; Tanasomwang, Varin; Thongrod, Supit; Dachanantawitaya, Narumol

doi:10.1021/jf010451i

Cited by 21 publications

(15 citation statements)

References 12 publications

(18 reference statements)

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“…In the first study, prawns were subjected to MO therapy of 75–150 mg kg − 1 for 7 days at 28–30°C (Brillantes et al . ). After the low dosing schedule, peak OTC levels in prawns were 9.28–10.20 mg kg − 1 in the head and 6.04–6.84 mg kg − 1 in muscle while following the high dosage schedule, respective drug levels were 18.20–19.93 and 10.91–12.84 mg kg − 1 .…”

Section: Aquaculture Pk Datamentioning

confidence: 97%

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A critical approach on pharmacokinetics, pharmacodynamics, dose optimisation and withdrawal times of oxytetracycline in aquaculture

Rigos

Smith

2013

Reviews in Aquaculture

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Oxytetracycline (OTC) is one of the antibacterial agents that is most commonly used to control bacterial infections in the aquaculture industry worldwide. Thorough knowledge and integration of appropriate drug pharmacokinetics (PK) and pharmacodynamics (PD) in therapeutic schedules are crucial in terms of treatment efficacy and cost, environmental welfare and potentially to human safety. This review provides a much needed critique of published OTC PK and a discussion on OTC PD, dose optimisation and importance of withdrawal times (WT). Overall, the pertinent literature reveals that most published OTC PK information is specific to farmed fish species. Significant variability in experimental design between PK studies rendered interspecies comparisons an almost impossible task. Published PK parameters exert variable relevance to practical application, and moreover, limited or nonexistent information is available for some relevant PK parameters. It is also demonstrated that there is a serious shortage of data simultaneously relating dose regimen, PK, PD data and clinical outcomes. This results in difficulties in applying available PK data to the improvement in current dose regimen. Efficacy studies and PK/PD data currently available do not allow improvements in the interpretive criteria used by laboratories; thus, for the present, clinical evaluations must rely on wild-type epidemiological cut-off values (CO WT ). Regarding OTC removal, the WT estimates that have been made for farmed crustaceans are much shorter than those for finfish. However, this fact does not necessarily ensure that these products are unlikely to result in contravention of regulatory limits.

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Section: Aquaculture Pk Datamentioning

confidence: 97%

“…For example, Brillantes et al . () determined that the concentration in all shrimp they sampled was below the target concentration by 10 days postdosing but then added 11 days to estimate a safe withdrawal time of 21 days. Nogueira‐Lima et al .…”

Section: Withdrawal Timesmentioning

confidence: 99%

A critical approach on pharmacokinetics, pharmacodynamics, dose optimisation and withdrawal times of oxytetracycline in aquaculture

Rigos

Smith

2013

Reviews in Aquaculture

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“…It has potential for use in farm-raised shrimp for the treatment of vibriosis like Vibrio alginolyticus and Vibrio harveyi. There are many studies on the pharmacokinetics and residues of OTC in marine and freshwater shrimp (Mohney et al 1997;Bermúdez-Almada et al 1999;Brillantes et al 2001;Uno 2002Uno , 2004Sangrungruang et al 2004;Reed et al 2004Reed et al , 2006Weifen et al 2004;Uno et al 2006;Poapolathep et al 2008a, b), but limited information of OTC dispositions in P. vannamei is available (Chiayvareesajja et al 2006;Nogueira-Lima et al 2006;Faroongsarng et al 2007;Gómez-Jimenez et al 2008). …”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Uno

Chaweepack²,

Ruangpan

2010

Aquacult Int

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The present study examined the pharmacokinetics and bioavailability of oxytetracycline (OTC) in vannamei shrimp (Penaeus vannamei) after intra-sinus (10 mg/kg) and oral (10 and 50 mg/kg) administration and also investigated the net changes of OTC residues in the shrimp after the thermal, acid and alkaline processing methods. The hemolymph concentrations of OTC after intra-sinus dosing were best described by a twocompartment open model. The oral bioavailability was found to be 48.2 and 43.6% at doses of 10 and 50 mg OTC/kg, respectively. The peak hemolymph concentrations after 10 and 50 mg OTC/kg doses were 3.37 and 17.4 lg/ml; the times to peak hemolymph concentrations were 7 and 10 h. The elimination half-lives were found to be 15.0 and 11.5 h for the low and high dose, respectively. The residual OTC was rapidly eliminated from muscle with the elimination half-life value of 19.4 and 15.4 h, respectively, for the groups treated with doses of 10 and 50 mg/kg. The residual OTC levels in the muscle fell below the MRL (0.2 lg/g) at 72 and 96-h post-dosing at dose levels of 10 or 50 mg/kg, respectively. Residual OTC levels in muscle and shell were approximately 20-50% lower in the thermal treatment such as boiling, baking and frying. By the acid treatment, OTC residues were reduced to [80%, while those were reduced to around 30% by alkaline treatment.

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“…, 2004; Chiayvareesajja et al. , 2006), but only limited information of OTC residue is available in freshwater shrimp (Brillantes et al. , 2001; Poapolathep et al.…”

Section: Introductionmentioning

confidence: 99%

Muscle tissue kinetics of oxytetracycline following intramuscular and oral administration at two dosages to giant freshwater shrimp (Macrobrachium rosenbergii)

Poapolathep

Jermnak

et al. 2008

Vet Pharm & Therapeutics

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The giant river shrimp (Macrobrachium rosenbergii), a native species of Thailand, is either exported for commercial purposes or supplied to meet the local requirements in Thailand. Limited pharmacokinetic information of the major antibiotic, oxytetracycline (OTC), is available for this freshwater shrimp. The purpose of the present study was to investigate the muscle tissue kinetics of OTC in M. rosenbergii following either intramuscular (i.m.) or oral (p.o.) administration at two dosages of 11 and 22 mg/kg body weight (b.w.). The concentration of OTC in shrimp tissues was measured using high-performance liquid chromatography (HPLC) equipped with a fluorescence detector. Muscle tissue concentrations were below the detection limit (LOD, 0.1 microg/g) after 96 and 120 h, following i.m. and p.o. administration, respectively. Peak muscle concentrations (C(max)) were 3.47 and 1.73 microg/g after i.m. and p.o. administration at a single dose of 11 mg/kg b.w. whereas they were 6.03 and 2.51 microg/g at a single dose of 22 mg/kg b.w., respectively. A noncompartment model was developed to describe the pharmacokinetics of OTC in the giant freshwater shrimp. The terminal half-lives of OTC were 28.68 and 28.09 h after i.m. and p.o. administration at a single dose of 11 mg/kg b.w., but 29.95 and 27.03 h at a single dose of 22 mg/kg b.w., respectively. The relative bioavailability was 82.32 and 64.67% following i.m. and p.o. administration, respectively. Based on the pharmacokinetic data, i.m. and p.o. administration with OTC at a dose of 11 mg/kg b.w. would be appropriate for use in giant freshwater shrimp farming. To avoid the OTC residue in shrimp muscle, it should take at least seven half-lives (8 days) to wash out the drug from the muscle of M. rosenbergii.

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Oxytetracycline Residues in Giant Freshwater Prawn (Macrobrachium rosenbergii)

Cited by 21 publications

References 12 publications

A critical approach on pharmacokinetics, pharmacodynamics, dose optimisation and withdrawal times of oxytetracycline in aquaculture

A critical approach on pharmacokinetics, pharmacodynamics, dose optimisation and withdrawal times of oxytetracycline in aquaculture

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Muscle tissue kinetics of oxytetracycline following intramuscular and oral administration at two dosages to giant freshwater shrimp (Macrobrachium rosenbergii)

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