Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice

Jia, Yongxing; Lu, Haojie; Peng, Yalin; Zhang, Baoshun; Gong, Xiaobao; Su, Jun; Zhou, You; Pan, Min‐Hui; Xu, Li

doi:10.1016/j.intimp.2018.01.014

Cited by 37 publications

(27 citation statements)

References 46 publications

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“…In this regard, Nrf2 is a key transcription factor that is essential for attenuating inflammation-and oxidative stress-associated diseases. Previous report has shown that the activation of Nrf2 not only rescues the tissues from oxidative damage but also exhibits a protective potential against inflammation in the pathogenesis of liver damage both in vivo and in vitro (Jia et al, 2018). Our results uncovered that bicyclol treatment dramatically inhibited IL-1b, IL-6, IL-18, and TNF-a generation and alleviated NLRP3 and MDA production.…”

Section: Discussionsupporting

confidence: 57%

Bicyclol Attenuates Acute Liver Injury by Activating Autophagy, Anti-Oxidative and Anti-Inflammatory Capabilities in Mice

et al. 2020

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Bicyclol, a novel synthetic antihepatitis drug, has been shown to protect against liver injury via various pharmacological activities. The purpose of the current study was to further investigate the protective effect of bicyclol against carbon tetrachloride (CCl 4)-induced acute liver injury (ALI) and its underlying molecular mechanism, particularly autophagic machinery, antioxidative, and anti-inflammatory potentials. Our results found that treatment with bicyclol significantly reduced CCl 4-induced hepatotoxicity by alleviating histopathological liver changes, decreasing the alanine transaminase levels, promoting autophagic flux, attenuating the expression of inflammatory cytokines, and modulating oxidative markers. Furthermore, bicyclol efficiently induced the conversion of LC3 and enhanced the liver expressions of ATG7 and Beclin-1. Meanwhile, bicyclol induced the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) and p62. These protective effects may be mediated by activation of AMP-activated protein kinase and inhibition of mTOR or MAPK signaling pathways. Taken together, our study firstly suggests that bicyclol has protective potential against CCl 4-induced hepatotoxicity, which might be closely associated with induction of autophagy, concomitant anti-oxidative stress, and anti-inflammatory response.

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Section: Discussionsupporting

confidence: 57%

Bicyclol Attenuates Acute Liver Injury by Activating Autophagy, Anti-Oxidative and Anti-Inflammatory Capabilities in Mice

et al. 2020

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“…Oxyresveratrol (Oxy, 4 ) is an RSV analog with an additional phenolic hydroxy group on the aromatic ring. In the study by Jia et al., Oxy could block the activation of TLR‐4/NF‐ κ B (Toll‐like receptor 4/nuclear factor‐kappa B) pathway and induce the activation of the Keap1‐Nrf2 signaling pathway, thus reducing the apoptosis of hepatocytes . Piceatannol ( 5 ) (3,4,3′,5′‐tetrahydroxy‐ trans ‐stilbene) from the seeds of Euphorbia lagascae has antiproliferative, anti‐inflammatory and antioxidative effects.…”

Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

“…In the study by Jia et al, Oxy could block the activation of TLR-4/NF-κB (Toll-like receptor 4/nuclear factor-kappa B) pathway and induce the activation of the Keap1-Nrf2 signaling pathway, thus reducing the apoptosis of hepatocytes. [36] Piceatannol (5) (3,4,3',5'-tetrahydroxy-trans-stilbene) from the seeds of Euphorbia lagascae has antiproliferative, anti-inflammatory and antioxidative effects. It is featured by orthosubstituted at the right phenyl hydroxy group, while the Oxy is meta-substituted.…”

Section: Resveratrol and Its Analogsmentioning

confidence: 99%

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

140

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The Keap1‐Nrf2/ARE signaling pathway is an important defense system against exogenous and endogenous oxidative stress injury. The dysregulation of the signaling pathway is associated with many diseases, such as cancer, diabetes, and respiratory diseases. Over the years, a wide range of natural products has provided sufficient resources for the discovery of potential therapeutic drugs. Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1‐Nrf2 protein–protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway. In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1‐Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered. In this view, we summarize the research status of natural polyphenols that have been found with apparent Nrf2 activation and their action modes. On the whole, this review may guide the design of novel Keap1‐Nrf2 activator.

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“…ALT and AST are abundant in liver cells. They are a sensitive and specific marker of liver injury 27 . Intraperitoneal administered with LPS (0.25 mg/Kg) and D-GalN (400 mg/Kg) for 5h markedly increased serum levels of ALT and AST confirming that acute liver injury occurred.…”

Section: ■ Discussionmentioning

confidence: 99%

Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice

2020

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Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice

Cited by 37 publications

References 46 publications

Bicyclol Attenuates Acute Liver Injury by Activating Autophagy, Anti-Oxidative and Anti-Inflammatory Capabilities in Mice

Bicyclol Attenuates Acute Liver Injury by Activating Autophagy, Anti-Oxidative and Anti-Inflammatory Capabilities in Mice

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice

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