Oxyresveratrol, a Stilbene Compound from <scp><i>Morus alba</i></scp> L. Twig Extract Active Against <i>Trichophyton rubrum</i>

Lu, Haojie; Jia, Yongxing; Peng, Yalin; Yu, Yanying; Sun, Silong; Yue, Meng-Ting; Pan, Min‐Hui; Zeng, Lingshu; Xu, Li

doi:10.1002/ptr.5926

Cited by 26 publications

(24 citation statements)

References 22 publications

(23 reference statements)

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“…The root is considered a substantial site for the biosynthesis of mulberroside A via glycosylation of oxyresveratrol (hydroxy-resveratrol), which is found as a precursor in the root of M. alba [35]. Oxyresveratrol is known as one of the key compounds in M. alba twigs, following its monoor di-glucosylated moieties [36][37][38], which supports the non-statistically significant higher amount in the twigs than in the root barks in this study.…”

Section: Discussionsupporting

confidence: 85%

Quantitative Comparison of the Marker Compounds in Different Medicinal Parts of Morus alba L. Using High-Performance Liquid Chromatography-Diode Array Detector with Chemometric Analysis

Doh

Lee

2020

Molecules

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It is thought that the therapeutic efficacy of Morus alba L. is determined by its biological compounds. We investigated the chemical differences in the medicinal parts of M. alba by analyzing a total of 57 samples (15 root barks, 11 twigs, 12 fruits, and 19 leaves). Twelve marker compounds, including seven flavonoids, two stilbenoids, two phenolic acids, and a coumarin, were quantitatively analyzed using a high-performance liquid chromatography-diode array detector and chemometric analyses (principal component and heatmap analysis). The results demonstrated that the levels and compositions of the marker compounds varied in each medicinal part. The leaves contained higher levels of six compounds, the root barks contained higher levels of four compounds, and the twigs contained higher levels of two compounds. The results of chemometric analysis showed clustering of the samples according to the medicinal part, with the marker compounds strongly associated with each part: mulberroside A, taxifolin, kuwanon G, and morusin for the root barks; 4-hydroxycinnamic acid and oxyresveratrol for the twigs and skimmin; chlorogenic acid, rutin, isoquercitrin, astragalin, and quercitrin for the leaves. Our approach plays a fundamental role in the quality evaluation and further understanding of biological actions of herbal medicines derived from various medicinal plant parts.

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Section: Discussionsupporting

confidence: 85%

Quantitative Comparison of the Marker Compounds in Different Medicinal Parts of Morus alba L. Using High-Performance Liquid Chromatography-Diode Array Detector with Chemometric Analysis

Doh

Lee

2020

Molecules

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“…Therefore, patients use various non-pharmacological agents to treat their tinea pedis. 7 Kiraz et al 6 15 We had also a high frequency of foot washing (51.3%, ≤5 in a day) because of the increased rate of ablution for worshipping in our study.…”

Section: Discussionmentioning

confidence: 77%

“…Tinea pedis is a public health problem as the most common dermatophyte infection. 2,7 Since there are a few studies that dwell on this issue socio-demographically, we conducted the current study. In our study, 85 patients (55.9%) had a history of at least one non-pharmacological agent use for tinea pedis.…”

Section: Discussionmentioning

confidence: 99%

The attitudes, behaviors, and opinions about non‐pharmacological agents in patients with tinea pedis

Polat

Belli²,

Karaali

et al. 2020

Dermatologic Therapy

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Tinea pedis affects the life quality distinctly and patients those with a prolonged disease often resort to non-medical methods. We sought to evaluate patients' knowledge about tinea pedis and approaches to the non-pharmacological agents. A crosssectional study was conducted on 152 patients with tinea pedis who answered the survey between July and November 2019. Demographic and clinical features, patients' attitudes, behaviors, and opinions about non-pharmacological treatments related to tinea pedis were evaluated. Of 152 patients, 65 (42.8%) were female and 87 (57.2%) were male. The frequency of at least one non-pharmacological agent use for tinea pedis was 55.9%. The most common non-pharmacological agent was cologne (27.0%), followed by saltwater, vinegar, and henna. The rate of nonpharmacological agent use was not significantly different between genders and patients with different education levels. Information sources for tinea pedis were dermatologists in only 42 patients (27.8%). The opinion that the disease will improve spontaneously was not significantly different between the groups according to the education level (P = .154). Tinea pedis needs awareness as a health problem particularly in Muslim populations. Patients should be prevented from applying wrong practices and informed about the risk factors, contagiousness, and treatment options by physicians.

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“…(4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; OXY; C 14 H 12 O 4 ) is a natural stilbenoid found in various plants, such as Morus alba L. (Lu et al, 2017). It has several biological activities, including neuroprotective and hepatoprotective effects (Shah et al, 2019;Jia et al, 2018;Chao et al, 2008).…”

Section: Oxyresveratrolmentioning

confidence: 99%

Syntheses and crystal structures of hydrated and anhydrous 1:2 cocrystals of oxyresveratrol and zwitterionic proline

2020

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The hydrated and anhydrous 1:2 cocrystals of oxyresveratrol (4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; OXY; C14H12O4) and proline [(S)-pyrrolidine-2-carboxylic acid; PRO; C5H9NO2], namely, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol bis[(S)-pyrrolidin-1-ium-2-carboxylate] monohydrate, C14H12O4·2C5H9NO2·H2O, and the anhydrous form, C14H12O4·2C5H9NO2, were obtained by crystallization at different temperatures. Both of them crystallize with orthorhombic (P212121) symmetry. The structures display N—H...O and O—H...O hydrogen-bonding interactions between PRO and PRO, OXY and OXY, and OXY and PRO. In the hydrated cocrystal, these types of contacts are also observed between the OXY, PRO and water molecules. A combination of these interactions leads to a three-dimensional supramolecular assembly in each case. Hirshfeld surfaces were used to gain further insight into the intermolecular interactions in the packing, including the relative percentage contributions of the significant intermolecular H...H and H...O/O...H contacts.

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Oxyresveratrol, a Stilbene Compound from Morus alba L. Twig Extract Active Against Trichophyton rubrum

Cited by 26 publications

References 22 publications

Quantitative Comparison of the Marker Compounds in Different Medicinal Parts of Morus alba L. Using High-Performance Liquid Chromatography-Diode Array Detector with Chemometric Analysis

Quantitative Comparison of the Marker Compounds in Different Medicinal Parts of Morus alba L. Using High-Performance Liquid Chromatography-Diode Array Detector with Chemometric Analysis

The attitudes, behaviors, and opinions about non‐pharmacological agents in patients with tinea pedis

Syntheses and crystal structures of hydrated and anhydrous 1:2 cocrystals of oxyresveratrol and zwitterionic proline

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