Oxyresveratrol: A bioavailable dietary polyphenol

Wan, Chen; Yeo, Samuel Chao Ming; Elhennawy, Mai Gamal; Lin, Hai‐Shu

doi:10.1016/j.jff.2016.01.020

Cited by 61 publications

(79 citation statements)

References 47 publications

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“…After i.v. administration at 10 mg kg −1 , Res rapidly declined with a half‐life time (t 1/2 ) estimated at 2.21 h. Res was widely distributed ( V = 1.78 L kg −1 ) and extensively cleared (clearance ( Cl ) = 6.63 ± 2.34 L h −1 kg −1 ), which was comparable to the recently published study on Res ( V = 1629 ± 893 mL kg −1 ; Cl = 107.3 ± 18.5 mL min −1 kg −1 ; Chen et al, ). As shown in Figure (a, c, e, g and i), Res was immediately metabolized into R3S, R4′S, R3G and R4′G, progressively increasing, peaking at 0.14, 0.16, 0.07 and 0.17 h, respectively.…”

Section: Resultssupporting

confidence: 82%

“… aThe apparent volume of distribution ( V ) was roughly estimated with the one‐compartment first‐order open model ( C = C 0 ∙e − kt ) using the first time data (Chen et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…The area under the Res or metabolite concentration in plasma vs time profile from the dosing time to the terminal sampling time (AUC 0– t ) was produced by trapezoidal rule. An additionally crucial parameter, apparent volume of distribution ( V ), was roughly estimated with the one‐compartment first‐order open model ( C = C 0 ·e − kt ) using the data collected in the first hour (Chen, Yeo, Elhennawy, & Lin, ).…”

Section: Methodsmentioning

confidence: 99%

“…The plasma profiles revealed that Res was rapidly eliminated, with an estimated half-life of 3.61 ± 0.72 h. Meanwhile, the glucuronide and sulfate conjugates were immediately detected at 5 min, which also proved the rapid transformation from Res. As depicted in Figure 3, the amounts of R3S (1.69 μM), R3G (6.28 μM) and R4′G (1.03 μM) at 5 min exceeded that of Res (0.76 μM), while the initial level of R4′S 4 Pharmacokinetic parameters of res and its metabolites by noncompartmental analysis in rats following a single intragastric administration of res at 50 mg kg −1 and intravenous administration at 10 mg kg −1 (n = 6 in each group, data expressed in means ± SD) The apparent volume of distribution (V) was roughly estimated with the one-compartment first-order open model (C = C 0 •e −kt ) using the first time data (Chen et al, 2016). b The volume of distribution (Vz/F) was estimated by noncompartmental analysis.…”

Section: Stabilitymentioning

confidence: 99%

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A simple LC–MS/MS method facilitated by salting‐out assisted liquid–liquid extraction to simultaneously determine trans‐resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay

Qiu

Dai

et al. 2017

Biomedical Chromatography

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A simple LC-MS/MS method facilitated by salting-out assisted liquid-liquid extraction (SALLE) was applied to simultaneously investigate the pharmacokinetics of trans-resveratrol (Res) and its major glucuronide and sulfate conjugates in rat plasma. Acetonitrile-methanol (80:20, v/v) and ammonium acetate (10 mol L ) were used as extractant and salting-out reagent to locate the target analytes in the supernatant after the aqueous and organic phase stratification, then the analytes were determined via gradient elution by LC-MS/MS in negative mode in a single run. The analytical method was validated with good selectivity, acceptable accuracy (>85%) and low variation of precision (<15%). SALLE showed better extraction efficiency of target glucuronide and sulfate conjugates (>80%). The method was successfully applied to determine Res and its four conjugated metabolites in rat after Res administration (intragastric, 50 mg kg ; intravenous, 10 mg kg ). The systemic exposures to Res conjugates were much higher than those to Res (AUC , i.v., 7.43 μm h; p.o., 8.31 μm h); Res-3-O-β-d-glucuronide was the major metabolite (AUC , i.v., 66.1 μm h; p.o., 333.4 μm h). The bioavailability of Res was estimated to be ~22.4%. The reproducible SALLE method simplified the sample preparation, drastically improved the accuracy of the concomitant assay and gave full consideration of extraction recovery to each target analyte in bio-samples.

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Section: Resultssupporting

confidence: 82%

“… aThe apparent volume of distribution ( V ) was roughly estimated with the one‐compartment first‐order open model ( C = C 0 ∙e − kt ) using the first time data (Chen et al, ).…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Stabilitymentioning

confidence: 99%

See 2 more Smart Citations

A simple LC–MS/MS method facilitated by salting‐out assisted liquid–liquid extraction to simultaneously determine trans‐resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay

Qiu

Dai

et al. 2017

Biomedical Chromatography

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“…For polyphenols, oral oxyresveratrol bioavailability is relatively high achieving 2 µM in rat plasma [33]which in humans would need an oral dose ~500mg by allometric scaling. This is within the range of our lowest dose (5 µM)that produced antioxidation.…”

Section: Post-treatment With Antioxidantsmentioning

confidence: 99%

Neuroprotective Effect of Artocarpus Lakoocha Extract and Oxyresveratrol Against Hydrogen Peroxide-Induced Toxicity in Sh-Sy5y Cells

Hasriadi

Wongon

Lapphanichayakool

et al. 2017

Int J Pharm Pharm Sci

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Objective: Artocarpuslakoocha Roxb. Is a traditional medical plant native to Southeast Asia and used as a dried aqueous extract so-called puaghaad. Its role (and its major ingredient, oxyresveratrol) as an antioxidant neuroprotectant were explored.Methods: Differentiated SH-SY5Y neuroblastoma cells in 96-well plates were challenged with 200 µM H2O2 for 4h and either Trolox (100 µM), oxyresveratrol (5-100 µM), or puaghaad (1.2-25 µg/ml) applied 2h before H2O2 or for 20 h after H2O2Results: Continuous presence of both H washout. Cell viability, mitochondrial function, intracellular ROS, and lipid peroxidation were assessed.2O 2 and antioxidant reduced mitochondrial function by ~50% but only by 30% with antioxidant. Sustained 24 h H2O2 showed no recoveries with antioxidants. Cell viability was modestly restored when antioxidants accompanied H2O2 for 4 h and both washed for another 20 h, but little recovery of mitochondrial function even though antioxidants removed ROS and prevent lipid peroxidation. Antioxidants added for 20 h after H2O2 Conclusion:These results show that mitochondrial protection was illusive, yet both tested compounds, puaghaad and oxyresveratrol, improved cell viability and especially ROS levels and lipid peroxidation. The potency oxyresveratrol on theredox-sensitive expression of antioxidant enzymes and its pharmacokinetics suggests that oral puaghaad could provide effective protection in transient neurodegenerative disease. marginally improve mitochondria and modestly restore cell viability, but lipid peroxidation was completely reversed.

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Oral delivery system enhanced the bioavailability of stilbenes: Resveratrol and pterostilbene

et al. 2018

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Stilbenes are a large group of compounds with the C C C skeleton, in which two aromatic rings are connected by an ethylene bridge. Resveratrol and its structural analog, pterostilbene, are by far the two most widely researched stilbenes in terms of their beneficial bioactivities. However, the bioefficacy of these compounds is greatly reduced when consumed orally due to their poor aqueous solubility, which leads to poor bioavailability. To overcome the limitation, strategies improving their solubility, absorption, and systemic concentration were applied when designing a suitable edible delivery system. This review will summarize the findings from the studies evaluating the oral bioavailability of stilbenes with emphasize on the resveratrol and pterostilbene. It will also include the edible delivery systems currently available and their effect on the oral bioavailability. © 2018 BioFactors, 44(1):5-15, 2018.

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Oxyresveratrol: A bioavailable dietary polyphenol

Cited by 61 publications

References 47 publications

A simple LC–MS/MS method facilitated by salting‐out assisted liquid–liquid extraction to simultaneously determine trans‐resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay

A simple LC–MS/MS method facilitated by salting‐out assisted liquid–liquid extraction to simultaneously determine trans‐resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay

Neuroprotective Effect of Artocarpus Lakoocha Extract and Oxyresveratrol Against Hydrogen Peroxide-Induced Toxicity in Sh-Sy5y Cells

Oral delivery system enhanced the bioavailability of stilbenes: Resveratrol and pterostilbene

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