Oxygenation and metabolic status of KHT tumors as measured simultaneously by 19F magnetic resonance imaging and 31P magnetic resonance spectroscopy

Molecular Imaging of Hypoxia

“…Progressive hypoxia in tumors during growth over a period of 2 wk can be observed (150,155). Many blood substitute emulsions were based on materials with multiresonant spectra (e.g., perfluorotributylamine, perfluorotripropylamine, and perfluorooctyl bromide), which complicated the imaging experiment, usually leading to signal loss.…”

Fluorine electron double resonance imaging for 19F MRI in low magnetic fields

“…4b shows that the SNR of the image intensity is inversely related to pO 2 . This is in contrast to 19 F MRI, where the image brightness is directly related to pO 2 because the increased pO 2 causes shorter T 1 relaxation times (31). In FEDRI, on the other hand, higher pO 2 broadens the EPR line width and hence the saturation of EPR transition is limited, resulting in reduced OE (29).…”

Current issues in the utility of 19 F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia

“…Numerous studies by 19 F NMR oximetry have reported tumour p O 2 measurements in a range of different rodent tumour models (Hees & Sotak 1993;Dardzinski & Sotak 1994;Mason et al 1994Mason et al , 1996Mason et al , 1998Baldwin & Ng 1996;Le et al 1997;Hunjan et al 1998Hunjan et al , 2001McIntyre et al 1999;van der Sanden et al 1999;Worden et al 1999;Nö th et al 2001;Song et al 2002;Zhao et al 2002) and these have been summarized in table 1. For comparison, literature p O 2 values measured for the same tumour type by the invasive Eppendorf electrode are also shown (Yeh et al 1995;Adam et al 1999;Robinson et al 1999).…”