Oxygen uptake and heart rate kinetics during dynamic upper and lower body exercise: an investigation by time-series analysis

Drescher, Uwe; Koschate, Jessica; Hoffmann, Uwe

doi:10.1007/s00421-015-3146-4

Cited by 18 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a number of possible explanations for the higher peak _ VO 2 values in TM exercise, including the energy cost of maintaining an upright posture (Miles-Chan et al, 2013;J udice et al, 2016) and/or factors related to work efficiency, skeletal muscle mass, and activation that occur in TM but not CE CPET. Muscle mass clearly plays a role; for example, peak _ VO 2 is, as expected, smaller in upper body ergometry compared with TM or CE CPET (Drescher et al, 2015). It is noteworthy that we could not find significant changes in any of our submaximal slopes in the transition from walking to running on the treadmill, suggesting that the predominant component of energy costs of TM exercise is related to velocity, mass, and incline.…”

Section: Lean Body Mass (Kg)supporting

confidence: 67%

The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults

et al. 2019

View full text Add to dashboard Cite

Cardiopulmonary exercise testing (CPET) modalities, treadmill (TM), and cycle ergometer (CE), influence maximal gas exchange and heart rate (HR) responses. Little is known regarding CPET modality effect on submaximal biomarkers during childhood and adolescence. Ninety‐four healthy participants (7–34 y.o., 53% female) performed TM and CE CPET to address two major gaps: (1) the effect of modality on submaximal CPET biomarkers, and (2) estimation of work rate in TM CPET. Breath‐by‐breath gas exchange enabled calculation of linear regression slopes such as trueV˙O2/ΔHR and ΔtrueV˙E/ΔtrueV˙CO2. Lean body mass (LBM) was measured with dual X‐ray absorptiometry. We tested a novel TM CPET estimate of work rate based on TM velocity2, incline, and body mass (VIM). Like the linear relationship between trueV˙O2 and work rate in CE CPET, trueV˙O2 increased linearly with TM VIM. TM ΔtrueV˙O2/ΔHR was highly correlated with CE (r = 0.92), and each increased substantially with LBM (P < 0.0001 for TM and CE). ΔtrueV˙O2/ΔHR was to a small (~8.7%) but significant extent larger in TM (1.6 mL/min/beat, P = 0.04). In contrast, TM and CE ΔtrueV˙E/ΔtrueV˙CO2 decreased significantly with LBM, supporting earlier observations from CE CPET. For both CE and TM, males had significantly higher ΔtrueV˙O2/ΔHR but lower ΔtrueV˙E/ΔtrueV˙CO2 than females. Novel TM CPET biomarkers such as ΔVIM/ΔHR and ∆trueV˙O2/ΔVIM paralleled effects of LBM observed in CE CPET. TM and CE CPET submaximal biomarkers are not interchangeable, but similarly reflect maturation during critical periods. CPET analysis that utilizes data actually measured (rather than estimated) may improve the clinical value of TM and CE CPET.

show abstract

Section: Lean Body Mass (Kg)supporting

confidence: 67%

The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The kinetics of HR, V O 2 musc and V O 2 pulm of the aged subjects in this study were slower compared with recently published data using the same protocol in young subjects [19,27]. These findings are in line with the results of former studies comparing old and young subjects [2-4, 17, 18, 41, 42].…”

Section: Comparison Of Hr V O 2 Musc and V O 2 Pulm Kineticssupporting

confidence: 90%

“…The distortion is caused by the transport of the 'oxygen uptake signal' through venous volume, O 2 stores and the V O 2 of the non-working parts of the body e. g., [9,27], as similarly outlined by Barstow et al [7]. In young subjects it was shown that V O 2 musc kinetics were different from V O 2 pulm kinetics [19,27]. No data of V O 2 musc for elderly subjects evaluated via PRBS protocols are available, although the protocol has been tested in children with cystic fibrosis [33].…”

Section: Abstract ▼mentioning

confidence: 97%

See 1 more Smart Citation

Muscular Oxygen Uptake Kinetics in Aged Adults

et al. 2016

Self Cite

View full text Add to dashboard Cite

Pulmonary oxygen uptake (V˙O2) kinetics and heart rate kinetics are influenced by age and fitness. Muscular V˙O2 kinetics can be estimated from heart rate and pulmonary V˙O2. In this study the applicability of a test using pseudo-random binary sequences in combination with a model to estimate muscular V˙O2 kinetics was tested. Muscular V˙O2 kinetics were expected to be faster than pulmonary V˙O2 kinetics, slowed in aged subjects and correlated with maximum V˙O2 and heart rate kinetics. 27 elderly subjects (73±3 years; 81.1±8.2 kg; 175±4.7 cm) participated. Cardiorespiratory kinetics were assessed using the maximum of cross-correlation functions, higher maxima implying faster kinetics. Muscular V˙O2 kinetics were faster than pulmonary V˙O2 kinetics (0.31±0.1 vs. 0.29±0.1 s; p=0.004). Heart rate kinetics were not correlated with muscular or pulmonary V˙O2 kinetics or maximum V˙O2. Muscular V˙O2 kinetics correlated with maximum V˙O2 (r=0.35; p=0.033). This suggests, that muscular V˙O2 kinetics are faster than estimates from pulmonary V˙O2 and related to maximum V˙O2 in aged subjects. In the future this experimental approach may help to characterize alterations in muscular V˙O2 under various conditions independent of motivation and maximal effort.

show abstract

“…For the T2D c group, V'O 2 musc kinetics seemed slower than HR kinetics. For comparison, HR kinetics have been shown to be faster than V'O 2 musc kinetics in healthy young subjects [14,28]. In sedentary aged subjects, V'O 2 musc kinetics were faster (but not significantly) than HR kinetics [29].…”

Section: Discussionmentioning

confidence: 99%

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

Koschate

Drescher

Baum

et al. 2017

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

The aim of this pilot study was to investigate whether there are differences in heart rate and oxygen uptake kinetics in type 2 diabetes patients, considering their cardiovascular medication. It was hypothesized that cardiovascular medication would affect heart rate and oxygen uptake kinetics and that this could be detected using a standardized exercise test. 18 subjects were tested for maximal oxygen uptake. Kinetics were measured in a single test session with standardized, randomized moderate-intensity work rate changes. Time series analysis was used to estimate kinetics. Greater maxima in cross-correlation functions indicate faster kinetics. 6 patients did not take any cardiovascular medication, 6 subjects took peripherally acting medication and 6 patients were treated with centrally acting medication. Maximum oxygen uptake was not significantly different between groups. Significant main effects were identified regarding differences in muscular oxygen uptake kinetics and heart rate kinetics. Muscular oxygen uptake kinetics were significantly faster than heart rate kinetics in the group with no cardiovascular medication (maximum in cross-correlation function of muscular oxygen uptake vs. heart rate; 0.32±0.08 vs. 0.25±0.06; p=0.001) and in the group taking peripherally acting medication (0.34±0.05 vs. 0.28±0.05; p=0.009) but not in the patients taking centrally acting medication (0.28±0.05 vs. 0.30±0.07; n.s.). It can be concluded that regulatory processes for the achievement of a similar maximal oxygen uptake are different between the groups. The used standardized test provided plausible results for heart rate and oxygen uptake kinetics in a single measurement session in this patient group.

show abstract

Oxygen uptake and heart rate kinetics during dynamic upper and lower body exercise: an investigation by time-series analysis

Cited by 18 publications

References 29 publications

The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults

The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults

Muscular Oxygen Uptake Kinetics in Aged Adults

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

Contact Info

Product

Resources

About