“…Fahim et al used three phase inverse fluidized bed bioreactor to produce biosurfactant production, i.e. surfactin and fenygcin by Bacillus subtilis [69]. Their results confirmed positive effect on lipopeptide production of the immobilization of B. subtilis on solid particles, reported by Chtioui et al (100).…”
Section: Immobilization and Cultivationsupporting
confidence: 80%
“…liquid and gas superficial velocities, surface tension of the liquid medium and the presence of solid particles. Fahim et al used the three phase inverse fluidized bed bioreactor to discuss the kLa effect on biosurfactant production by Bacillus subtilis [69]. Oxygen transfer increased up to 175% and up to 24% with the increase of superficial gas and liquid velocities, respectively.…”
Section: Cultivation Conditions For Production Of Surfactinmentioning
“…Fahim et al used three phase inverse fluidized bed bioreactor to produce biosurfactant production, i.e. surfactin and fenygcin by Bacillus subtilis [69]. Their results confirmed positive effect on lipopeptide production of the immobilization of B. subtilis on solid particles, reported by Chtioui et al (100).…”
Section: Immobilization and Cultivationsupporting
confidence: 80%
“…liquid and gas superficial velocities, surface tension of the liquid medium and the presence of solid particles. Fahim et al used the three phase inverse fluidized bed bioreactor to discuss the kLa effect on biosurfactant production by Bacillus subtilis [69]. Oxygen transfer increased up to 175% and up to 24% with the increase of superficial gas and liquid velocities, respectively.…”
Section: Cultivation Conditions For Production Of Surfactinmentioning
Lipopeoptides are amphiphilic compounds combining interesting physicochemical properties and biological activities. Due to their high foaming capacity in aerated bioreactor, the development of scalable bioprocesses for their production is a major bottleneck. In addition, the genes involved in the biosynthesis of these lipopeptides are mainly regulated by the quorum sensing, a global regulatory mechanism depending on cell density and known to be activated in biofilms. Several approaches have thus been considered in literature taking into account two criteria, on one side, to favor, control or avoid foam formation and on the other side, to use planktonic or immobilized (biofilm) cells. These different bioprocesses are discussed in the present review along with the purification strategies proposed for extracting and concentrating these biosurfactants.
“…Estudos recentes (FAHIM et al 2013;COUTTE et al 2013) apontam que biorreatores com configuração clássica (tanque aerado) não são adequados para a produção de biossurfactantes do tipo lipopeptídeos, devido à formação excessiva de espuma durante o processo.…”
Section: Schimidellunclassified
“…e relataram produção de aproximadamente 1000 mg.L -1 . Fahim et al (2013) utilizaram reator trifásico de fase inversa de leito fluidizado e produziram cerca de 2000 mg.L -1 de surfactina bruta.…”
RESUMO -Biossurfactantes, ou surfactantes biológicos, constituem uma série de espécies químicas com propriedades tensoativa similares aos surfactantes sintéticos, entretanto com algumas vantagens: baixa toxidade, reduzida CMC, possibilidade de produção por fontes renováveis, além de tolerância às condições extremas de temperatura, pH e força iônica. Entretanto, a viabilidade econômica da produção em escala industrial de biossurfactantes depende do desenvolvimento de estratégias e processos que visem a minimização dos custos envolvidos no processo, como por exemplo, técnicas estatísticas de otimização. O objetivo deste estudo foi analisar os efeitos da agitação e aeração em biorreator de bancada sobre a transferência de oxigênio (k LA ) e produção de biossurfactante do tipo lipopeptídeo pela cepa ICA56, através de planejamento experimental. Dentre as condições analisadas, observou-se que a maior produção de biossurfactante (115 mg.L -1 ) ocorreu em aeração de 1 L.min -1 de O 2 e agitação de 200 rpm e que elevadas condições de aeração e agitação maximizam a transferência de oxigênio, mas podem inibir a produção de biossurfactante e o crescimento celular da cepa.
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