Oxygen therapy in preterm infants: recommendations for practice

Ali, Sanoj K M; Mohammed, Nancy; Qureshi, Nadia K.; Gupta, Samir

doi:10.1016/j.paed.2020.10.001

Cited by 11 publications

(8 citation statements)

References 5 publications

(3 reference statements)

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“…Another retrospective study by Kumaravel et al revealed that neonates with a birth weight of less than 1,500 grams had higher rates of laser photocoagulation therapy for ROP treatment compared with higher birth weights [ 20 ]. This might be because the lower the birthweight, the more likely it is for a neonate to require oxygenation intervention which is an independent risk factor for the development of ROP [ 21 , 22 ]. Thus, we recommend that oxygenation therapy for preterms should be given with caution, and regular monitoring is advised.…”

Section: Discussionmentioning

confidence: 99%

Preterm Assessment at Birth and Its Association With the Development of Retinopathy of Prematurity (ROP): A Tertiary Care Center Experience

Bokhary¹,

Abumohssin²,

Alghamdi³

et al. 2022

Cureus

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Background: Prematurity is a leading cause of neonatal morbidity and mortality and is associated with insufficient development of multiple body structures, including neurovascular and retinal tissues. Retinopathy of prematurity (ROP) is an abnormal vaso proliferation of the neonatal retina that results from an arrest in the normal development of the retinal nerve and blood supply. Incidence has been increasing due to advancements in intensive care and survival of preterm neonates, as well as improvements in screening methods for ROP.Objectives: The objective is to assess the initial clinical and laboratory characteristics of preterm infants at the time of birth to identify population-specific risk factors for the development of ROP in a tertiary care center in western Saudi Arabia.Methods and materials: This was a retrospective record review conducted at King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia. The study included 37 patients diagnosed with ROP. Their ROP staging, complete blood count, appearance, pulse, grimace, activity and respiration (APGAR) score, and birth characteristics were all analyzed.Results: Thirty-seven neonates diagnosed with ROP and who met the study inclusion criteria were included. our results showed a female predominance of 51.4%, the mean age of the pregnancy was 27.18 ± 2.29 weeks, the mean birth weight was 0.8 ± 0.26, and 66.7% of our sample was delivered by the cesarean section. A significant association was found between the birth weight and the development of ROP in the right eye (p = 0.026); another significance was found between gestational age and the development of ROP in the same eye (p = 0.016).Conclusions: A low birth weight and gestational age show a significant association with the development of ROP. Early identification and treatment of ROP are important to preserve a neonate's eyesight.

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Section: Discussionmentioning

confidence: 99%

Preterm Assessment at Birth and Its Association With the Development of Retinopathy of Prematurity (ROP): A Tertiary Care Center Experience

Bokhary¹,

Abumohssin²,

Alghamdi³

et al. 2022

Cureus

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“…As infants who are born prematurely have yet to complete a full-term pregnancy, the respiratory organ and system are often not sufficient to support the respiratory needs of a premature infant. (43) Odds ratio calculation between gestational age and duration of oxygen therapy, as seen in table 4, shows that infants born at ≤ 32 weeks gestation are 2.06 times (95% CI 0.313-13.574) more likely to receive oxygen supplementation for ≥ 7 days. Duration of oxygen supplementation is adjusted to the infant's clinical condition.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Retinopathy of Prematurity in Tertiary Hospital

Raniasari¹,

Prastyani²,

Etika³

et al. 2021

IJRP

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Introduction: Retinopathy of prematurity is a potentially blinding disease of the eye due to abnormal retinal vascularization. Gestational age, preterm birth, oxygen therapy, and RBC transfusion are some of the factors associated with ROP. Purpose: This study aims to determine the relation between gestational age, birth weight, duration of oxygen therapy, and RBC transfusion with ROP. Methods: This research is a case-control study using medical records data from Dr. Soetomo General Hospital in the period of January -June 2019. Data is analyzed using logistic regression analysis in SPSS v. 25. Results: The case group consists of 22 patients with ROP while the control group consists of 66 patients without ROP. Gestational age (p=0.030; OR=3.10, 95% CI 1.113-8.606) and duration of oxygen therapy (p=0.012; OR=3.75, 95% CI 1.342-10.481) shows a statistically significant relation with ROP. There is no relation between birth weight (p=0.098; OR= 2.30, 95% CI 0.857-6.171) and RBC transfusion (p=0.881; OR=1.09; 95% CI 0.343-3.480) with ROP. Conclusions: There is a relation between gestational age and duration of oxygen therapy with ROP. Meanwhile, birth weight and RBC transfusion have no relation with ROP.

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“…Mechanical ventilation and apnea of prematurity, caused by immature respiratory control in preterm neonates, sometimes result in intermittent hypoxic events (Eichenwald et al, 2016; Martin et al, 2011). Oxygen supplementation is an established intervention to counter these periods of hypoxia but increases the risk of exposure to a hyperoxic environment (Ali et al, 2021; Oei & Vento, 2019). Various animal experimental studies, some of which include models of preterm birth, have shown a link between neonatal hyperoxia exposure and changes in cardiac structure and function, resulting in adult heart failure (Bertagnolli et al, 2014; Velten et al, 2011, 2014).…”

Section: The Role Of Maternal and Early Life Environmentmentioning

confidence: 99%

Understanding the preterm human heart: What do we know so far?

Schuermans

Lewandowski

2022

The Anatomical Record

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Globally, preterm birth affects more than one in every 10 live births. Although the short-term cardiopulmonary complications of prematurity are well known, long-term health effects are only now becoming apparent. Indeed, preterm birth has been associated with elevated cardiovascular morbidity and mortality in adulthood. Experimental animal models and observational human studies point toward changes in heart morphology and function from birth to adulthood in people born preterm that may contribute to known long-term risks.Moreover, recent data support the notion of a heterogeneous cardiac phenotype of prematurity, which is likely driven by various maternal, early, and late life factors. This review aims to describe the early fetal-to-neonatal transition in preterm birth, the different structural and functional changes of the preterm human heart across developmental stages, as well as potential factors contributing to the cardiac phenotype of prematurity.

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Oxygen therapy in preterm infants: recommendations for practice

Cited by 11 publications

References 5 publications

Preterm Assessment at Birth and Its Association With the Development of Retinopathy of Prematurity (ROP): A Tertiary Care Center Experience

Preterm Assessment at Birth and Its Association With the Development of Retinopathy of Prematurity (ROP): A Tertiary Care Center Experience

Risk Factors of Retinopathy of Prematurity in Tertiary Hospital

Understanding the preterm human heart: What do we know so far?

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