BackgroundTo ensure continued adaptation to extra-uterine life, all newborns have their physiological vital signs monitored intermittently post birth until discharge; these are tracked against predefined 'normal' reference ranges. Ascertaining an evidence base for 'normal' reference ranges is important for the early detection of deterioration in this population, who are at risk of not adapting to the extra-uterine environment due to being born prior to term.
AimThe studies in this thesis aim to determine physiological vital sign reference ranges for well newborns between 34 +0/7 and 36 +6/7 weeks of gestation.
ObjectivesThe objectives of the studies in this thesis were to: systematically summarise the evidence in peer-reviewed literature on physiological vital sign reference ranges for well newborns greater than or equal to 34 weeks of gestation; to review contemporary neonatal and midwifery textbooks and publicly available grey literature (i.e. organisational websites, hospital policies and early warning tools) for vital sign reference ranges pertaining to well newborns of ≥ 34 +0/7 weeks of gestation; to determine whether there are differences in vital signs in gestational age groups; and, if differences are identified, to establish physiological vital sign reference ranges for the well late preterm group and validate the reference ranges.
Research DesignA systematic review of literature was initially undertaken followed by a scoping review of textbooks and grey literature to identify vital sign reference ranges for newborns ≥ 34 +0/7 weeks of gestation. Quantitative research methods were used to meet the remaining study objectives. Study One was conducted as a single site prospective observational study of 30 newborns, comprised of three gestational age groups: late preterm (34 +0/7 -36 +6/7 ), early term (37 +0/7 -38 +6/7 ), and term (39 +0/7 -40 +6/7 ). This involved continuously recording heart rate, respiratory rate, and peripheral oxygen saturation for up to six hours and periodic monitoring of temperature and blood pressure to determine whether physiological vital signs differed between the groups. The results of Study One informed the design of Study Two. This involved a shorter recording time of up to two hours and periodic monitoring of ii 0 Abstract temperature and blood pressure on 120 well, late preterm newborns in a single site prospective observational study. The reference ranges established in Study Two underwent validation in Study Three, in which a cross-sectional design was used to validate the data with data from the medical records of a group of late preterm newborns.
ResultsThe searches of literature resulted in primary studies (n = 10), textbooks (n = 7) and grey literature (n = 11). Inconsistencies in and a dearth of vital sign ranges for gestational age groups other than term were identified. Details of how reference ranges were calculated were only provided in the peer reviewed literature.Study One generated a combined total of 284,542 heart rate values, 275,826 respiratory rate values...