Oxygen plasma treatments of polydimethylsiloxane surfaces: effect of the atomic oxygen on capillary flow in the microchannels

Bartali, Ruben; Morganti, Elisa; Lorenzelli, Leandro; Micheli, V.; Gottardi, Gloria; Scarpa, Marina; K, Safeen Mian; Pandiyan, Rajesh; Laidani, N.

doi:10.1049/mnl.2017.0230

Cited by 47 publications

(27 citation statements)

References 38 publications

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“…Contact angle values for non-irradiated PET@toner substrates increased with the tested grayscale levels, ranging from 73° (0% coverage) to 111° (75% coverage), and a further increase in the grayscale level did not lead to any increase in the substrate hydrophobicity. As expected, laser toner turned out to be highly hydrophobic, with a wettability comparable with materials such as PDMS (~110°) [ 49 , 50 ] and poly(tetrafluoroethylene) (PTFE) (107°) [ 51 ]. Toner hydrophobicity turned out to be far superior to pristine PET foil, which is easily noticeable on sessile drop photographs (See Figure 5 a).…”

Section: Resultsmentioning

confidence: 77%

Versatile and Easily Designable Polyester-Laser Toner Interfaces for Site-Oriented Adsorption of Antibodies

Drozd

Ivanova

Tokarska

et al. 2022

IJMS

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Laser toners appear as attractive materials for barriers and easily laminated interphases for Lab-on-a-Foil microfluidics, due to the excellent adhesion to paper and various membranes or foils. This work shows for the first time a comprehensive study on the adsorption of antibodies on toner-covered poly(ethylene terephthalate) (PET@toner) substrates, together with assessment of such platforms in rapid prototyping of disposable microdevices and microarrays for immunodiagnostics. In the framework of presented research, the surface properties and antibody binding capacity of PET substrates with varying levels of toner coverage (0–100%) were characterized in detail. It was proven that polystyrene–acrylate copolymer-based toner offers higher antibody adsorption efficiency compared with unmodified polystyrene and PET as well as faster adsorption kinetics. Comparative studies of the influence of pH on the effectiveness of antibodies immobilization as well as measurements of surface ζ-potential of PET, toner, and polystyrene confirmed the dominant role of hydrophobic interactions in adsorption mechanism. The applicability of PET@toner substrates as removable masks for protection of foil against permanent hydrophilization was also shown. It opens up the possibility of precise tuning of wettability and antibody binding capacity. Therefore, PET@toner foils are presented as useful platforms in the construction of immunoarrays or components of microfluidic systems.

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Section: Resultsmentioning

confidence: 77%

Versatile and Easily Designable Polyester-Laser Toner Interfaces for Site-Oriented Adsorption of Antibodies

Drozd

Ivanova

Tokarska

et al. 2022

IJMS

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“…At a take‐off angle of 20°, these measurements revealed an approximate elemental molar ratio [O]/[Si] of ≈1 within the siloxane network, which is expected for PDMS. [ 48,51–53 ] We would like to note here, that at a take off angle of 20°, the analysis depth of the X‐ray beam reduces to 3.4 nm (compared to 10 nm at 90°). Therefore, the XPS signal of the oPDMS stripes (≥15 nm height) can be isolated from the underlying substrate surface.…”

Section: Resultsmentioning

confidence: 94%

Shaping Metallic Nanolattices: Design by Microcontact Printing from Wrinkled Stamps

Wang

Sperling

Reifarth

et al. 2020

Small

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A method for the fabrication of well‐defined metallic nanostructures is presented here in a simple and straightforward fashion. As an alternative to lithographic techniques, this routine employs microcontact printing utilizing wrinkled stamps, which are prepared from polydimethylsiloxane (PDMS), and includes the formation of hydrophobic stripe patterns on a substrate via the transfer of oligomeric PDMS. Subsequent backfilling of the interspaces between these stripes with a hydroxyl‐functional poly(2‐vinyl pyridine) then provides the basic pattern for the deposition of citrate‐stabilized gold nanoparticles promoted by electrostatic interaction. The resulting metallic nanostripes can be further customized by peeling off particles in a second microcontact printing step, which employs poly(ethylene imine) surface‐decorated wrinkled stamps, to form nanolattices. Due to the independent adjustability of the period dimensions of the wrinkled stamps and stamp orientation with respect to the substrate, particle arrays on the (sub)micro‐scale with various kinds of geometries are accessible in a straightforward fashion. This work provides an alternative, cost‐effective, and scalable surface‐patterning technique to fabricate nanolattice structures applicable to multiple types of functional nanoparticles. Being a top‐down method, this process could be readily implemented into, e.g., the fabrication of optical and sensing devices on a large scale.

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“…Therefore, the unmodified PDMS is restricted to producing water in oil emulsion (w/o) (Mata et al., 2005 ). In order to increase the hydrophilic properties of PDMS, surface modifications can be done using ultraviolet irradiation, oxygen plasma (Long et al., 2017 ; Ruben et al., 2017 ; Zhu et al., 2020 ), corona discharge (Bashir et al., 2018 ), layer by layer deposition (Choi et al., 2018 ; Zhang et al., 2019 ), sol-gel methods (Abate et al., 2008 ), and surface treatment with surfactant (Fu et al., 2017 ; Khemthongcharoen et al., 2021 ). Using oxygen plasma, PDMS-based microfluidic surface modification carried out by Long et al.…”

Section: Approaches For Efficient Microfluidicsmentioning

confidence: 99%

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

et al. 2022

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Microfluidics is used to manipulate fluid flow in micro-channels to fabricate drug delivery vesicles in a uniform tunable size. Thanks to their designs, microfluidic technology provides an alternative and versatile platform over traditional formulation methods of nanoparticles. Understanding the factors that affect the formulation of nanoparticles can guide the proper selection of microfluidic design and the operating parameters aiming at producing nanoparticles with reproducible properties. This review introduces the microfluidic systems’ continuous flow (single-phase) and segmented flow (multiphase) and their different mixing parameters and mechanisms. Furthermore, microfluidic approaches for efficient production of nanoparticles as surface modification, anti-fouling, and post-microfluidic treatment are summarized. The review sheds light on the used microfluidic systems and operation parameters applied to prepare and fine-tune nanoparticles like lipid, poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles as well as cross-linked nanoparticles. The approaches for scale-up production using microfluidics for clinical or industrial use are also highlighted. Furthermore, the use of microfluidics in preparing novel micro/nanofluidic drug delivery systems is presented. In conclusion, the characteristic vital features of microfluidics offer the ability to develop precise and efficient drug delivery nanoparticles.

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Oxygen plasma treatments of polydimethylsiloxane surfaces: effect of the atomic oxygen on capillary flow in the microchannels

Cited by 47 publications

References 38 publications

Versatile and Easily Designable Polyester-Laser Toner Interfaces for Site-Oriented Adsorption of Antibodies

Versatile and Easily Designable Polyester-Laser Toner Interfaces for Site-Oriented Adsorption of Antibodies

Shaping Metallic Nanolattices: Design by Microcontact Printing from Wrinkled Stamps

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

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