Oxygen-Induced Embryopathy and the Significance of Glutathione-Dependent Antioxidant System in the Rat Embryo During Early Organogenesis

Ishibashi, Miwa; Akazawa, Shoichi; Sakamaki, Hiroyuki; Matsumoto, Kazunari; Yamasaki, Hironori; Yamaguchi, Yoshihiko; Goto, Shinji; Urata, Yoshishige; Kondo, Takahito; Nagataki, Shigenobu

doi:10.1016/s0891-5849(96)00338-3

Cited by 73 publications

(56 citation statements)

References 26 publications

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“…In the fetus exposed to an episode of ischemia, alteration of DNA can increase, in vivo, by a factor from 12 to 128 [25]. Despite active repair activities [19], some of the damaged DNA is subject to permanent alterations which can induce cellular apoptosis or tissue necrosis [26,27], fetal growth retardation [27], death of the embryo [28] or latent pathologies [29,30], some of which break out when the organism faces new disequilibria between ROS production and elimination, notably during postnatal life.…”

Section: Overview Of Radical Phenomenamentioning

confidence: 99%

“…It has been reported that oxygen partial pressure displays positive effects on embryo development only within a narrow range and that an oxidative stress can occur, with possibly potential lethal effects, below (slowing down of ATP synthesis) or above this range (direct peroxidation of membranes due to an excess of oxygen and radical chain initiation) [37]. In vitro, deviation of the oxygen partial pressures from the normal can induce oxidative stress and end embryo-toxicity if antioxidant enzymes (AOE) or antioxidant components are not provided [28,50,51]. During in utero embryo development, embryopathies occur, apparently due to oxygen induced ROS production, but in less well characterized circumstances [28,50,52].…”

Section: Oxygen Partial Pressure As a Factor Of Ros Production Duringmentioning

confidence: 99%

“…In vitro, deviation of the oxygen partial pressures from the normal can induce oxidative stress and end embryo-toxicity if antioxidant enzymes (AOE) or antioxidant components are not provided [28,50,51]. During in utero embryo development, embryopathies occur, apparently due to oxygen induced ROS production, but in less well characterized circumstances [28,50,52].…”

Section: Oxygen Partial Pressure As a Factor Of Ros Production Duringmentioning

confidence: 99%

“…In rat embryo culture, embryopathy can be induced by a high concentration of oxygen (20%) which can increase the rate of H 2 O 2 formation (+180%) and decrease the GSH content in the cells [28]. Two enzymes associated with ROS trapping by GSH, glutathione peroxydase (Gpx) and glutathione reductase (Gred), which could help to maintain the GSH content of the cells, are respectively dependent on vitamin B6 [67] and B2 [68].…”

Section: Ros Formation In the Mitochondria Of Placental And Fetal Tismentioning

confidence: 99%

“…GSH production and metabolism are of the utmost importance to prevent pathologies of gestation [5,8,28], both for the radical scavenging properties of GSH [12,28] and for its role in the control of the redox status inside the cells and the control of gene expression [12,79]. Another radical trapping component, ubiquinone, which is also essential for energy metabolism [65] has also been reported to be essential for gestation outcome or viability of stem cells in the mouse.…”

Section: Defense Against Ros and The Outcome Of Gestationmentioning

confidence: 99%

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Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

2006

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-In mammals, radical oxygen species (ROS) are essential factors of cell replication, differentiation and growth (oxidative signal), notably during gestation, but are also potentially damaging agents. In Women, ROS play a role in remodeling of uterine tissues, implantation of the embryo, settlement of the villi and development of blood vessels characteristic of gestation. The body stores of vitamins and minerals of gestating females are used to keep ROS fluxes at a level corresponding to oxidative signals and to prevent an imbalance between their production and scavenging (oxidative stress), which would be detrimental to the mother and fetus. There is some evidence that, although based on different regulatory mechanisms, most of the effects of ROS reported in humans also occur in pregnant ruminant females, some of which have been actually reported. Many vitamins and trace elements have dual effects in the organism of mammals: (a) they are involved in the control of metabolic pathways or/and gene expression, (b) but most of the time they also display ROS trapping activity or their deficiencies induce high rates of ROS production. Deficiencies induce different disorders of gestation and can be induced by different kinds of stress. An example is given, corresponding to the decreased contents of cobalt of forages, when exposed to sustained heavy rains, so that the supply of vitamins B12 to the organism of the ruminant that grazes them is reduced and failure of gestation is induced. Outdoor exposure of ruminants to adverse climatic conditions by itself can increase the vitamin and trace element requirements. Adaptation of production systems taking into account these interactions between gestation and sources of stress or change of the quality of feeding stuffs as well as further developments of knowledge in that field is necessary to promote sustainable agricultural practices.gestation / ovine / bovine / vitamins / trace elements / antioxidant enzymes / radical oxygen species / radical phenomena

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Section: Overview Of Radical Phenomenamentioning

confidence: 99%

Section: Oxygen Partial Pressure As a Factor Of Ros Production Duringmentioning

confidence: 99%

Section: Oxygen Partial Pressure As a Factor Of Ros Production Duringmentioning

confidence: 99%

Section: Ros Formation In the Mitochondria Of Placental And Fetal Tismentioning

confidence: 99%

Section: Defense Against Ros and The Outcome Of Gestationmentioning

confidence: 99%

See 3 more Smart Citations

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

2006

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Co-expression of gamma-glutamylcysteine synthetase sub-units in response to cisplatin and doxorubicin in human cancer cells

Iida

Mori

et al. 1999

Int. J. Cancer

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Stem Cell‐Based Methods for Identifying Developmental Toxicity Potential

Palmer

Burrier

Egnash

2014

Methods and Principles in Medicinal Chemistry

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Oxygen-Induced Embryopathy and the Significance of Glutathione-Dependent Antioxidant System in the Rat Embryo During Early Organogenesis

Cited by 73 publications

References 26 publications

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

Co-expression of gamma-glutamylcysteine synthetase sub-units in response to cisplatin and doxorubicin in human cancer cells

Stem Cell‐Based Methods for Identifying Developmental Toxicity Potential

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