Oxygen in acute and chronic wound healing

Abstract

Oxygen is a prerequisite for successful wound healing due to the increased demand for reparative processes such as cell proliferation, bacterial defence, angiogenesis and collagen synthesis. Even though the role of oxygen in wound healing is not yet completely understood, many experimental and clinical observations have shown wound healing to be impaired under hypoxia. This article provides an overview on the role of oxygen in wound healing and chronic wound pathogenesis, a brief insight into systemic and topical oxygen treatment, and a discussion of the role of wound tissue oximetry. Thus, the aim is to improve the understanding of the role of oxygen in wound healing and to advance our management of wound patients.

Dehydrated human amnion/chorion membrane regulates stem cell activity in vitro

“…A sustained state of inflammation resulting from local hypoxia, bacterial colonization, repeated ischemia–reperfusion injury, and cellular as well as systemic changes of aging, is a hallmark of chronic wounds 47. Data suggests that a balance of stem cell secreted immunoregulatory proteins in a chronic wound may be crucial to transition the wound out of this sustained inflammatory phase and into a normal acute healing phase to achieve wound re‐epithelialization.…”

Importance of physiotherapy in prevention and treatment of pressure sores in post-stroke patients

“…Biofilm bakteryjny skupia szczególną uwagę ze względu na oporność na antybiotyki i środki dezynfekujące, powodując zagrożenie dla pacjentów, u których występują rany odleżynowe. Problem ten stanowi poważne wyzwanie dla współczesnej farmakologii [19].…”

“…Oprócz uszkodzenia gospodarza bakterie przyciągają leukocyty i reaktywne formy tlenu, co powoduje amplifikację cytokin prozapalnych i proteazy, a to eskaluje kaskady zapalenia [19]. Na skutek wymienionych zmian odleżyny mogą być źródłem zakażeń tkanek miękkich i kości.…”

Hyperbaric Oxygen Therapy: Using Evidence-Based Medicine to Heal Injured Brain Tissue

“…genation [15], thus stimulating wound repair [12][13][14]. The US Food and Drug Administration has approved HBOT for 14 indications, providing 30 years of safe and successful clinical use.…”