Oxygen‐dependent hyperpolarized <sup>129</sup>Xe brain MR

Li, Haidong; Zhang, Zhiying; Zhong, Jiahao; Ruan, Weiwei; Han, Yeqing; Sun, Xiaofeng; Ye, Chaohui; Zhou, Xin

doi:10.1002/nbm.3465

Cited by 12 publications

(14 citation statements)

References 32 publications

(38 reference statements)

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“…Therefore, the exposure time of Xe to paramagnetic O 2 should be minimal. After inhalation, the O 2 concentration in the lung and the blood will also contribute to the faster relaxation of Xe nuclei, thereby limiting the detectable Xe signal in different tissues [26].…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

“…Once dispersed into solution, T 1 of 129 Xe drops to ∼100 s for water at 9.4 T or shorter values, depending on parameters such as the solvent and the protein content in solution. In vivo conditions cause further shortening of T 1 and reflect the additional impact from paramagnetic species such as oxygen (during gas delivery via inhalation) and deoxy-haemoglobin in the bloodstream [26]. The Xe host used for HyperCEST must therefore provide conditions that ensure a buildup of saturation transfer that is faster than the intrinsic T 1 relaxation of the bulk Xe.…”

Section: General Considerations For Hyperpolarized 129xe Nmrmentioning

confidence: 99%

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Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

Jayapaul

Schröder

2019

Contrast Media & Molecular Imaging

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Spin hyperpolarization techniques have enabled important advancements in preclinical and clinical MRI applications to overcome the intrinsic low sensitivity of nuclear magnetic resonance. Functionalized xenon biosensors represent one of these approaches. They combine two amplification strategies, namely, spin exchange optical pumping (SEOP) and chemical exchange saturation transfer (CEST). The latter one requires host structures that reversibly bind the hyperpolarized noble gas. Different nanoparticle approaches have been implemented and have enabled molecular MRI with 129Xe at unprecedented sensitivity. This review gives an overview of the Xe biosensor concept, particularly how different nanoparticles address various critical aspects of gas binding and exchange, spectral dispersion for multiplexing, and targeted reporter delivery. As this concept is emerging into preclinical applications, comprehensive sensor design will be indispensable in translating the outstanding sensitivity potential into biomedical molecular imaging applications.

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Section: Discussion and Future Directionsmentioning

confidence: 99%

Section: General Considerations For Hyperpolarized 129xe Nmrmentioning

confidence: 99%

Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

Jayapaul

Schröder

2019

Contrast Media & Molecular Imaging

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“…Hyperpolarized xenon gas was produced via spin‐exchange optical pumping using a homebuilt polarizer . The polarizer was equipped with a 75 W narrow‐width laser array (QPC Laser, Sylmar, CA, USA) and worked in continuous‐flow mode, and the source gas mixture consisted of 1% natural abundance xenon (26.4% 129 Xe), 10% N 2 , and 89% 4 He.…”

Section: Methodsmentioning

confidence: 99%

Quantitative evaluation of pulmonary gas‐exchange function using hyperpolarized ¹²⁹Xe CEST MRS and MRI

Zhang

Xitao

et al. 2018

NMR in Biomedicine

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Hyperpolarized Xe gas MR has been a powerful tool for evaluating pulmonary structure and function due to the extremely high enhancement in spin polarization, the good solubility in the pulmonary parenchyma, and the excellent chemical sensitivity to its surrounding environment. Generally, the quantitative structural and functional information of the lung are evaluated using hyperpolarized Xe by employing the techniques of chemical shift saturation recovery (CSSR) and xenon polarization transfer contrast (XTC). Hyperpolarized Xe chemical exchange saturation transfer (Hyper-CEST) is another method for quantifying the exchange information of hyperpolarized Xe by using the exchange of xenon signals according to its different chemical shifts, and it has been widely used in biosensor studies in vitro. However, the feasibility of using hyperpolarized Xe CEST to quantify the pulmonary gas exchange function in vivo is still unclear. In this study, the technique of CEST was used to quantitatively evaluate the gas exchange in the lung globally and regionally via hyperpolarized Xe MRS and MRI, respectively. A new parameter, the pulmonary apparent gas exchange time constant (T ), was defined, and it increased from 0.63 s to 0.95 s in chronic obstructive pulmonary disease (COPD) rats (induced by cigarette smoke and lipopolysaccharide exposure) versus the controls with a significant difference (P = 0.001). Additionally, the spatial distribution maps of T in COPD rats' pulmonary parenchyma showed a regionally obvious increase compared with healthy rats. These results indicated that hyperpolarized Xe CEST MR was an effective method for globally and regionally quantifying the pulmonary gas exchange function, which would be helpful in diagnosing lung diseases that are related to gas exchange, such as COPD.

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“…Hence, there should be an optimal pulmonary oxygen concentration for a given quantity of hyperpolarised 129 Xe in the brain. These relationships have been explored in theoretical and in vivo experiments for improving the 129 Xe signal in brain ( Figure 26) [337]. Cs NMR wih biological and biomedical systems and samples are based on the fact that caesium can be used as a substitute for potassium [338].…”

Section: A B Cmentioning

confidence: 99%

NMR-Active Nuclei for Biological and Biomedical Applications

Patching¹

2016

J Diagn Imaging Ther

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Nuclear magnetic resonance (NMR) spectroscopy is a principal well-established technique for analysis of chemical, biological, food and environmental samples. This article provides an overview of the properties and applications of NMR-active nuclei (39 nuclei of 33 different elements) used in NMR measurements (solution-and solid-state NMR, magnetic resonance spectroscopy, magnetic resonance imaging) with biological and biomedical systems and samples. The samples include biofluids, cells, tissues, organs or whole body from different organisms (humans, animals, bacteria, fungi, plants) for detecting and quantifying metabolites or environmental samples (water, soils, sediments). Isolated biomolecules (peptides, proteins, nucleic acids) can be analysed for elucidation of atomic-resolution structure, conformation and dynamics and for characterisation of ligand and drug binding, and of protein-ligand, protein-protein and protein-nucleic acid interactions. NMR can be used for drug screening and pharmacokinetics and to provide information in the design and discovery of new drugs. NMR can also measure translocation of ions and small molecules across lipid bilayers and membranes, characterise structure, phase behaviour and dynamics of membranes and elucidate atomic-resolution structure, orientation and dynamics of membrane-embedded peptides and proteins.Keywords: biological and biomedical applications; drug screening; dynamics; magnetic resonance imaging; membrane proteins; metabolomics; MRI; NMR-active nuclei; nuclear magnetic resonance; protein structure INTRODUCTION1 UCLEAR magnetic resonance (NMR) spectroscopy is one of the principal techniques used for analysis of biological and biomedical systems and samples. This can include the identification, quantification and monitoring of ions, small molecules and biomolecules in studies of metabolism and biological function in human and animal cells and tissues, bacterial cells and spores, fungi and plants. Similar types of measurements can be performed on environmental samples such as water, soils and sediment. NMR is able to elucidate atomic-resolution structure, conformation, molecular mechanism, dynamics and exchange processes (on timescales of picoseconds to seconds) in biomolecules, especially peptides, proteins and nucleic acids. NMR can be used for the observation, quantification and characterisation of ligand and drug binding to biomolecules, and for characterisation of ligandprotein, protein-protein and protein-nucleic acid interactions. NMR can be used for drug screening and it can acquire structural, binding and kinetic information for the design and discovery of new drugs. It can then monitor the absorption, distribution, metabolism and excretion (ADME) of administered drugs in pharmacokinetics studies. OPEN ACCESS PEER-REVIEWED*NMR can be used for the observation, quantification and kinetic characterisation of ion and smallmolecule translocation across lipid bilayers and biological membranes, including those of cells, tissues and vesicles. Solid-state NM...

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Oxygen‐dependent hyperpolarized ¹²⁹Xe brain MR

Cited by 12 publications

References 32 publications

Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

Quantitative evaluation of pulmonary gas‐exchange function using hyperpolarized ¹²⁹Xe CEST MRS and MRI

NMR-Active Nuclei for Biological and Biomedical Applications

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Oxygen‐dependent hyperpolarized 129Xe brain MR

Cited by 12 publications

References 32 publications

Nanoparticle-Based Contrast Agents for129Xe HyperCEST NMR and MRI Applications

Nanoparticle-Based Contrast Agents for129Xe HyperCEST NMR and MRI Applications

Quantitative evaluation of pulmonary gas‐exchange function using hyperpolarized 129Xe CEST MRS and MRI

NMR-Active Nuclei for Biological and Biomedical Applications

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Oxygen‐dependent hyperpolarized ¹²⁹Xe brain MR

Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

Quantitative evaluation of pulmonary gas‐exchange function using hyperpolarized ¹²⁹Xe CEST MRS and MRI