Oxygen Consumption during Surface-Induced Deep Hypothermia under Halothane Anesthesia

Ishitoya, Takeshi; Sato, So; Dibenedetto, Giuseppe; Vanini, Vittorio; Mohri, Hitoshi; Merendino, K. Alvin; Dillard, David H.

doi:10.1016/s0003-4975(10)64069-6

Cited by 6 publications

(1 citation statement)

References 3 publications

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“…5,17,19 PvCO 2 is expected to change slowly in response to respiratory or circulatory alterations since a corresponding change in CO 2 stores has to occur. 9 However, in this study, PvCO 2 decreased by about 10% in the first few minutes at the commencement of CPB. Since readily exchangeable CO 2 in the body amounts to 15-20 litres, 20 if that decrease had reflected an analogous decrease in tissue PCO 2 , a large amount of CO 2 should have been removed from the body in addition to metabolically produced CO 2 .…”

Section: Discussioncontrasting

confidence: 66%

Impaired carbon dioxide transport during and after cardiopulmonary bypass

Cavaliere

2000

Perfusion

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Changes in the CO2 carrying power of blood were evaluated during and after cardiopulmonary bypass (CPB) by calculating the equation of the whole blood CO2 dissociation curve and the ratio between the arterial-venous differences of CO2 content and CO2 tension (Ra-v). Sixteen patients undergoing normothermic CPB for coronary revascularization were studied; arterial and mixed venous blood gas analyses were performed prior to CPB, at the end of first cardioplegia infusion, 25 and 45 min after CPB commencement and 10 min after the termination of CPB. After CPB commencement, the whole blood CO2 dissociation curve became flatter and did not further change during or after CPB. Ra-v decreased from 1.06 +/- 0.16 to 0.72 +/- 0.12 ml/mmHg after the start of CPB and did not change significantly during CPB; it was still 0.73 +/- 0.13 ml/mmHg after CPB. The data indicate that during CPB the amount of CO2 removed from tissues by 1 litre of blood decreases by about 30% and that impairment in CO2 transport persists after the restoration of physiological circulation. Impairment in CO2 transport is mainly caused by haemodilution, but it could be worsened by acidosis.

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Section: Discussioncontrasting

confidence: 66%

Impaired carbon dioxide transport during and after cardiopulmonary bypass

Cavaliere

2000

Perfusion

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Do Oxygen Consumption and Carbon Dioxide Production Affect Cardiac Output After Cardiopulmonary Bypass?

Damask¹,

Weissman²,

Askanazi³

et al. 1987

Arch Surg

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Decreased critical mixed venous oxygen tension and critical oxygen transport during induced hypothermia in pigs

Willford

Hill

White

et al. 1986

J Clin Monitor Comput

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The effects of hypothermia on oxygen delivery and tolerance to hypoxia were studied in 8 normothermic (36.8 degrees C) and 10 hypothermic (29.3 degrees C) pigs that had been anesthetized and surgically implanted with instruments. Cardiac output (QT), VO2 [oxygen consumption, or QT X C(a-v)O2, where C(a-v)O2 is arteriovenous oxygen content difference], arterial and mixed venous blood gas values, and lactate concentrations were measured as the animals were made progressively hypoxic. Under control, normoxic conditions, mixed venous oxygen tension (PvO2) was 41.4 +/- 2.1 mm Hg (mean +/- SE) in the normothermic animals and 26.1 +/- 1.6 mm Hg in the hypothermic animals; these values are close to those predicted in our previous theoretical analysis. To study tolerance to hypoxia during hypothermia, critical PvO2 and critical total oxygen transport (TOT = QT X CaO2, where CaO2 is oxygen content of arterial blood) were determined by decreasing the inspired oxygen concentration (FIO2) in steps and measuring the point where VO2 and blood lactate levels became PO2 or TOT dependent. Again as predicted, the critical PVO2 was lower in the hypothermic animals (15.5 +/- 1.0 mm Hg at 29.3 degrees C compared with 22.0 +/- 1.4 mm Hg at 36.8 degrees C), but critical venous oxyhemoglobin saturation values were not statistically different at the two temperatures. Critical TOT was also decreased during hypothermia, as was the margin of reserve in both PVO2 and TOT (the difference between the normoxic and the critical values).

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Oxygen Consumption during Surface-Induced Deep Hypothermia under Halothane Anesthesia

Cited by 6 publications

References 3 publications

Impaired carbon dioxide transport during and after cardiopulmonary bypass

Impaired carbon dioxide transport during and after cardiopulmonary bypass

Do Oxygen Consumption and Carbon Dioxide Production Affect Cardiac Output After Cardiopulmonary Bypass?

Decreased critical mixed venous oxygen tension and critical oxygen transport during induced hypothermia in pigs

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