Do Oxygen Consumption and Carbon Dioxide Production Affect Cardiac Output After Cardiopulmonary Bypass?

Damask, Michael C.; Weissman, Charles; Askanazi, Jeffrey; Rosenbaum, Stanley H.; Elwyn, David H.; Hyman, Allen I.

doi:10.1001/archsurg.1987.01400210064009

Cited by 14 publications

(2 citation statements)

References 23 publications

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“…Only Damask et al have measured VCO 2 , and that was during hypothermic CPB. 15 Like VO 2 , VCO 2 was temperature dependent. They measured VO 2 and VCO 2 at 28-32°C during initial cooling, at 21-27°C during further cooling, and at 28-32°C during rewarming.…”

Section: Discussionmentioning

confidence: 95%

“…8 Production of lactate in hypoxic areas, then transportation to oxygen-rich areas, would lead to a net increase in global RQ for a given oxygen consumption. This mechanism might explain the rise in RQ found by Damask et al 15 Most previous measurements of VO 2 during CPB have been conducted during hypothermia [15][16][17] and few have been done during normothermic CPB. Starr measured VO 2 in both dogs and humans during normothermic CPB.…”

Section: Discussionmentioning

confidence: 96%

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Oxygen consumption, carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass

Engoren

Evans

2000

Perfusion

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The objective of this study was to measure oxygen consumption, carbon dioxide production and lactic acid levels during normothermic cardiopulmonary bypass. A prospective study was undertaken in a tertiary care community hospital, involving 20 adults undergoing cardiopulmonary bypass with prolonged (>65 min) crossclamping of the aorta. O2 consumption, CO2 production, hemoglobin and lactic acid levels were measured 5, 35 and 65 min after crossclamping of the aorta. O2 consumption was 79.7 +/- 14.5, 78.8 +/- 15.4 and 81.5 +/- 14.1 ml/min/m2 at 5, 35 and 65 min after crossclamping the aorta. CO2 production was 61.8 +/- 42.9, 60.6 +/- 26.3 and 62.2 +/- 35.9 ml/min/m2 at the same times. Lactic acid levels were 1.6 +/- 0.5 mM/dl at all three times and did not correlate with O2 consumption or CO2 production. In conclusion, although oxygen consumption was low, there was no evidence of abnormal lactate or anaerobic metabolism to suggest tissue ischemia.

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Section: Discussionmentioning

confidence: 95%