Oxygen and Carbon Dioxide Dual Gas-Responsive and Switchable Microgels Prepared from Emulsion Copolymerization of Fluoro- and Amino-Containing Monomers

Lei, Lei; Zhang, Qi; Shi, Shuxian; Zhu, Shiping

doi:10.1021/la504829j

Cited by 46 publications

(54 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a typical example, Yuan's group reported CO 2 ‐“breathing” vesicles that displayed a tunable membrane permeability upon CO 2 stimulation to realize a selective release. Inspired by CO 2 ‐responsive polymers, rapid progress has been made in O 2 ‐responsive assemblies in the past three years . Nevertheless, to date, O 2 ‐responsive vesicles are scarcely reported.…”

Section: Introductionmentioning

confidence: 99%

“Breathing” CO₂‐, O₂‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

Song

Shang

Zhang

et al. 2017

Macromol. Rapid Commun.

View full text Add to dashboard Cite

group [26] who prepared an O 2 -"breathing" vesicle upon alternately purging with O 2 and Ar. Noteworthy, SRPVs with dual or multiresponsiveness have attracted enormous attention because multiresponsive systems can greatly improve their versatility in a variety of applications. [31][32][33][34] In contrast to lots of contact-triggered stimuli responses, light is a contact-free and environment-friendly stimulus. [35] Therefore, light is one of the most common triggers to realize remote controlled release. [36,37] So far, to the best of our knowledge, combining light responsiveness with CO 2 and O 2 -responsiveness to prepare triple-responsive vesicles has not yet been explored. A further challenge of such a vesicular system, besides the synthetic challenge, is how to maintain its "breathing"-responsive behavior instead of causing a sharp disassembly or a vesicle-tomicelle transition upon external stimuli (CO 2 , O 2 , and light). Usually, apart from cross-linked vesicles, a suitable polymer structure is an efficient strategy to endow SRPVs with a swelling responsive behavior to achieve a tunable membrane permeability. [15,38] In the present work, we report on the first CO 2 -, O 2 -, and lightresponsive vesicles from an amphiphilic triblock copolymer. To fabricate "breathable" vesicles, the work from Feng's group was referred to for the design of suitable chemical structures of triblock copolymers. [38] In this case, poly(N,N-dimethylamino ethyl methacrylate-co-2,2,2-trifluoroethyl methacrylate) (P(DMAEMAco-TFEMA)) with CO 2 and O 2 -responsiveness was chosen as the middle block, and poly(4-(4-methoxy-phenylazo)phenoxy methacrylate) (PMEPPMA) with light responsiveness was chosen as the end block. Due to the rigid structure of PMEPPMA, selfassembled vesicles can exhibit only swollen transitions upon CO 2 and O 2 stimulation, rather than switching to micelles or dissociating into unimers. Based on this suitable chemical structure and stimuli responsiveness, such vesicles present a "breathing" behavior under external stimulation (see Scheme 1), indicating the membrane permeability of such vesicles can be controlled via a single stimulus or various stimuli combinations. Furthermore, using Calcein as a model, it is demonstrated that the vesicles with their altering membrane permeability could serve as potential nanocarriers for an efficient rate-tunable controlled drug release. Results and DiscussionHerein, a CO 2 -, O 2 -, and light-responsive amphiphilic triblock copolymer, poly[(ethylene glycol)methyl ether]-block-poly(N,Ndimethylamino ethyl methacrylate-co-2,2,2-trifluoroethyl

show abstract

Section: Introductionmentioning

confidence: 99%

“Breathing” CO₂‐, O₂‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

Song

Shang

Zhang

et al. 2017

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…Zhang and Zhu reported O 2 and CO 2 dual responsive nanoaggregates of fluoro‐ and amino‐containing polymers . They also developed O 2 and CO 2 dual gas‐responsive and switchable microgels . CO 2 has offered great opportunities and possibilities due to its “green” feature.…”

Section: Introductionmentioning

confidence: 99%

“…[ 14 ] They also developed O 2 and CO 2 dual gas-responsive and switchable microgels. [ 15 ] CO 2 has offered great opportunities and possibilities due to its "green" feature.…”

Section: Introductionmentioning

confidence: 99%

CO₂‐Breathing Induced Reversible Activation of Mechanophore within Microgels

Lei

Zhang

et al. 2016

Macromol. Rapid Commun.

Self Cite

View full text Add to dashboard Cite

In this work, CO2 -breathing induced reversible activation of mechanophore within microgels is reported. The microgels are prepared through soap-free emulsion polymerization of CO2 -switchable monomer 2-(diethylamino)ethyl-methacrylate, using spiropyran (SP) based mechanophore MA-SP-MA as cross-linker. The microgels can be swollen by CO2 aeration. The swelling of microgels activates the SP mechanophore into merocyanine, causing distinguished color and fluorescence change. Moreover, these transitions are highly reversible, and the initial states of microgels can be easily recovered by "washing off" CO2 with N2 . The present contribution represents the first example of CO2 -breathing activation of mechanophore within microgels.

show abstract

“…Synthesis route of P(DEA-co-FS) microgel and schematic representation of its CO 2 and O 2 -responsive behaviour 241. Reprinted from ref.…”

mentioning

confidence: 99%

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

2016

View full text Add to dashboard Cite

CO2 is an ideal trigger for switchable or stimuli-responsive materials because it is benign, inexpensive, green, abundant, and does not accumulate in the system. Many different CO2-responsive materials including polymers, latexes, solvents, solutes, gels, surfactants, and catalysts have been prepared. This review focuses on the preparation, self-assembly, and functional applications of CO2-responsive polymers. Detailed discussion is provided on the synthesis of CO2-responsive polymers, in particular using reversible deactivation radical polymerization (RDRP), formerly known as controlled/living radical polymerization (CLRP), a powerful technique for the preparation of well-defined (co)polymers with precise control over molecular weight distribution, chain-end functional groups, and polymer architectural design. Self-assembly in aqueous dispersed media is highlighted as well as emerging potential applications.

show abstract

Oxygen and Carbon Dioxide Dual Gas-Responsive and Switchable Microgels Prepared from Emulsion Copolymerization of Fluoro- and Amino-Containing Monomers

Cited by 46 publications

References 35 publications

“Breathing” CO₂‐, O₂‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

“Breathing” CO₂‐, O₂‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

CO₂‐Breathing Induced Reversible Activation of Mechanophore within Microgels

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

Contact Info

Product

Resources

About

Oxygen and Carbon Dioxide Dual Gas-Responsive and Switchable Microgels Prepared from Emulsion Copolymerization of Fluoro- and Amino-Containing Monomers

Cited by 46 publications

References 35 publications

“Breathing” CO2‐, O2‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

“Breathing” CO2‐, O2‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

CO2‐Breathing Induced Reversible Activation of Mechanophore within Microgels

CO2-responsive polymeric materials: synthesis, self-assembly, and functional applications

Contact Info

Product

Resources

About

“Breathing” CO₂‐, O₂‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

“Breathing” CO₂‐, O₂‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

CO₂‐Breathing Induced Reversible Activation of Mechanophore within Microgels

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications