Oxolinic Acid Residues in Tissues of Cultured Rainbow Trout and Ayu Fish

Kasuga, Yoji; Sugitani, Akira; Yamada, Fujizo; Arai, Makoto; Morikawa, Susumu

doi:10.3358/shokueishi.25.512

Cited by 22 publications

(7 citation statements)

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“…Conversely, at colder acclimation temperatures less metabolites are present and compound t½s are longer. This is consistent with numerous temperature studies examining a variety of pharmaceuticals and other xenobiotics (Collier et al 1978; Varanasi et al 1981; Salte and Liestol 1983; Kasuga et al 1984; Jacobsen 1989; van Ginneken et al 1991; Bjorklund et al 1992; Kleinow et al 1994). While these in vivo findings suggest that warmer temperatures result in greater biotransformation and subsequent elimination, in vitro studies with membrane-bound systems suggest activity compensation with temperature change.…”

Section: Temperature Alters Xenobiotic Elimination In Fishsupporting

confidence: 88%

Seasonal influences on PCB retention and biotransformation in fish

James

Kleinow

2013

Environ Sci Pollut Res

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There is extensive evidence that fish from waters with PCB-contaminated sediments accumulate PCBs and related chemicals, and that people who eat fish from contaminated waters have higher body burdens of PCBs and PCB metabolites than those who do not. PCBs and their metabolites are potentially toxic, thus it is important to human health to understand the uptake, biotransformation and elimination of PCBs in fish, since these processes determine the extent of accumulation. The intestinal uptake of PCBs present in the diet of fish into fish tissues is a process that is influenced by the lipid composition of the diet. Biotransformation of PCBs in fish, as in mammals, facilitates elimination, although many PCB congeners are recalcitrant to biotransformation in fish and mammals. Sequential biotransformation of PCBs by cytochrome P450 and conjugation pathways is even less efficient in fish than in mammalian species, thus contributing to the retention of PCBs in fish tissues. A very important factor influencing overall PCB disposition in fish is water temperature. Seasonal changes in water temperature produce adaptive physiological and biochemical changes in fish. While uptake of PCBs from the diet is similar in fish acclimated to winter or summer temperatures, there is evidence that elimination of PCBs occurs much more slowly when the fish is acclimated at low temperatures than at warmer temperatures. Research to date suggests that the processes of elimination of PCBs are modulated by several factors in fish including seasonal changes in water temperature. Thus, the body burden of PCBs in fish from a contaminated location is likely to vary with season.

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Section: Temperature Alters Xenobiotic Elimination In Fishsupporting

confidence: 88%

Seasonal influences on PCB retention and biotransformation in fish

James

Kleinow

2013

Environ Sci Pollut Res

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“…It can be demonstrated that the pharmacological properties of these drugs (absorption and excretion) are specifically temperature-dependent. The excretion time of OTC is an almost linear function of water temperature (see also Salte & Liest01 1983), while that of OA seems either to be independent of water temperature or to diminish slightly with decreasing water temperature (see also Kasuga et al 1984). and TMP has a considerably longer withdrawal time at 6°C than at 12°C and 18"C, as is also pointed out by McCracken el al.…”

Section: Figure4mentioning

confidence: 62%

“…There is, as expected, a general accumulation of the three drugs in the metabolic and excretory organs, such as the liver, kidney, skin and gall-bladder (Herman et al 1969;McCarthy, Stevenson & Salsbury, 1974;Cartmell et al 1976;Fujihara, Kano & Fukui 1984;Kasuga et al 1984;Keck et al 1984). It is not stated in the literature whether the drugs are excreted in their original form or as metabolites, but it is likely that they can be excreted in both forms, since fish can metabolise other drugs (e.g.…”

Section: Figure4mentioning

confidence: 64%

Withdrawal times of freshwater rainbow trout, Salmo gairdneri Richardson, after treatment with oxolinic acid, oxytetracycline and trimetoprim

Jacobsen¹

1989

Journal of Fish Diseases

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. Oxolinic acid (OA), oxytetracyline (OTC) and trimetoprim (TMP) were investigated in whole gutted rainbow trout, Salmo gairdneri Richardson, and in their skin, muscle and blood, at 6, 12 and 18°C. Concentrations of drugs were measured by high‐pressure liquid chromatography. It is recommended that withdrawal times for rainbow trout be based on whole gutted rainbow trout and not, as in earlier investigations, from residual concentrations in muscle. Any concentrations in rainbow trout feed were found to be stable during the pelleting process used and up to 81 days after pelleting. The absorption of the drugs in rainbow trout show different temperature dependencies. A quantitative comparison of our overall data from this work with individual results from earlier investigations was undertaken. Suggested withdrawal times for freshwater rainbow trout treated with these drugs are: for OTC, 90 days below 6°C, 70 days between 6 and 12°C and 60 days above 12°C; for TMP, 60 days below 8°C and 40 days above 8°C; for OA, 20 days at approximately 18°C.

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“…Consequently, oxolinic acid is particulary efficient against devastating diseases such as Yersiniosis and Vibriosis (Rodgers & Austin, 1983;Gogny et al, 1990). Many studies on oxolinic acid residues have been published on a variety of fish (Kasuga et al, 1984;Archimbault et al, 1988;Ueno et al, 1988a;Ueno et al, 1988b;Jacobsen, 1989;Ishida, 1990;Steffenak et al, 1991;Ishida, 1992). Other studies are available on the pharmacokinetics of oxolinic acid after a bolus intravascular injection, mostly in salmonid fish (BjoÈ rklund & Bylund, 1991;Rogstad et al, 1993;Martinsen & Horsberg, 1995).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of oxolinic acid in sea‐bass, Dicentrarchus labrax (L., 1758), after a single rapid intravascular injection

Poher¹,

Blanc²,

Loussouarn³

1997

Vet Pharm & Therapeutics

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The pharmacokinetics of oxolinic acid was studied in sea-bass (Dicentrarchus labrax). The fish were kept in seawater at 15.2 degrees C with a 12 h/12 h photoperiod. Oxolinic acid was injected in the caudal vein of anaesthetized sea-bass in a single rapid intravascular administration at a dose of 10 mg/kg of body weight. Plasma concentrations of oxolinic acid were determined using two analytical methods, a classic plate diffusion bioassay using Escherichia coli and a high performance liquid chromatography (HPLC) using solid phase extraction with an internal standard and a U.V. detection. The mean recoveries were 99.6% and 110.8% and determination limits were 0.04 microg/mL and 0.02 microg/mL, for the bioassay and the HPLC respectively. Compared to other fish species, the oxolinic acid was rapidly (absorption half life, t(a1/2) = 0.69 h) distributed to body tissues outside the blood volume (volume of central compartment, Vc = 0.4 L/kg) and presented a large volume of distribution (Vdss = 2.55 L/kg). Considering its disappearance from the central compartment (rate constant: central-eliminated, k10 = 0.16 h[-1]) and its total body clearance (Cl[t] = 0.066 L/kg x h), the elimination phase of the oxolinic acid in sea-bass was shorter than in trout kept in freshwater, and longer than in salmon in seawater. Consequently, the area under the concentration-time curve (AUC = 157 microg x h/mL) and the mean residence time (MRT = 42 h) were relatively low and short, respectively.

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Oxolinic Acid Residues in Tissues of Cultured Rainbow Trout and Ayu Fish

Cited by 22 publications

References 0 publications

Seasonal influences on PCB retention and biotransformation in fish

Seasonal influences on PCB retention and biotransformation in fish

Withdrawal times of freshwater rainbow trout, Salmo gairdneri Richardson, after treatment with oxolinic acid, oxytetracycline and trimetoprim

Pharmacokinetics of oxolinic acid in sea‐bass, Dicentrarchus labrax (L., 1758), after a single rapid intravascular injection

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