OxLDL plasma levels in patients with Alzheimer's disease

Grossi, Marina Felipe; Carvalho, Maria das Graças; Silveira, Josianne Nicácio; Gonçalves, Gisele Santos; Gomes, Karina Braga; Bicalho, Maria Aparecida; Silva, Iêda de Fátima Oliveira

doi:10.1590/0004-282x20180012

Cited by 6 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pretreatment with probiotics for six weeks before induction of AD by Aβ(1–42) was associated with significant changes in aforementioned biochemical parameters as compared to the sham group. However, Grossi et al (2018) did not report any significant differences in TC, high-density lipoprotein-cholesterol, or low-density lipoprotein-cholesterol levels between patients with AD and those without; however, in this study TG levels were reported to be lower in AD patients than controls. In addition, Akbari et al (2016) showed that treatment with probiotics for 12 weeks in patients with AD positively impacts cognitive function, but is not associated with any significant changes in lipid profiles.…”

Section: Discussioncontrasting

confidence: 89%

The Effects of Probiotic Lactobacillus and Bifidobacterium Strains on Memory and Learning Behavior, Long-Term Potentiation (LTP), and Some Biochemical Parameters in β-Amyloid-Induced Rat’s Model of Alzheimer’s Disease

Rezaeiasl

Salami

Sepehri

2019

pnf

View full text Add to dashboard Cite

This study assessed the effects of probiotic supplementation on spatial learning and memory, long-term potentiation (LTP), paired-pulse facilitation (PPF) ratios, nitric oxide (NO) concentrations, and lipid profiles in a rat model of amyloid beta (Aβ)(1–42)-induced Alzheimer’s disease (AD). Forty rats were randomly divided into 4 groups. The sham (control and prevention) group received intracerebroventricular (ICV) injections of artificial cerebrospinal fluid, the Alzheimer group received ICV injection of Aβ(1–42), and the probiotic+Alzheimer group received 500 mg probiotics daily (15×109 colony-forming unit) by gavage for 4 weeks before and 2 weeks after injection of Aβ(1–42). The Morris water maze test was performed for evaluation of spatial learning and memory. LTP and PPF ratios were measured to evaluate longterm synaptic plasticity and pre-synaptic mechanisms, respectively. The results showed that probiotic supplementation significantly improved learning, but not memory impairment, and increased PPF ratios compared to those in the Alzheimer group. Both Aβ(1–42) injection and probiotic supplementation alone did not significantly effect plasma level of NO. Probiotic supplementation of rats in the probiotic (6 weeks)+Alzheimer group decreased serum levels of total cholesterol, triglyceride, and very low-density lipoprotein-cholesterol significantly compared to the Alzheimer group. The results of this study suggest that probiotic supplementation may positively impact learning capacity and LTP in rats with AD, most likely via the release of neurotransmitters via presynaptic mechanisms or via a protective effect on serum lipid profiles.

show abstract

Section: Discussioncontrasting

confidence: 89%

The Effects of Probiotic Lactobacillus and Bifidobacterium Strains on Memory and Learning Behavior, Long-Term Potentiation (LTP), and Some Biochemical Parameters in β-Amyloid-Induced Rat’s Model of Alzheimer’s Disease

Rezaeiasl

Salami

Sepehri

2019

pnf

View full text Add to dashboard Cite

show abstract

“…There are studies that state that high levels of HDL-C are associated with a lower risk of AD, while the low levels of HDL-C are accompanied by hyperinsulinemia, which is a risk factor for the disease. In addition, cholesterol HDL is critical for the maturation of synapses, as well as maintaining synaptic plasticity, which influences Aβ clearance and the formation of neurofibrillary tangles that are directly linked to the development and evolution of AD stages (BUTTON et al, 2019;GROSSI et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study

et al. 2020

View full text Add to dashboard Cite

Assess the nutritional and biochemical state of patients with Alzheimer Disease (AD) compared to a control group. This is an observational, case-control and descriptive type study, based on the recruiting of 22 elderly individuals with a clinical diagnosis of AD considered as the case group, and 22 other elderly individuals considered as the control group. Evaluations were made using the results from the following scales Mini Nutritional Assessment (MNA), Mini Mental State Examination (MMSE), anthropometric measurements for obtaining the body mass index (BMI) and biochemical analyses. The analyses were performed on the program SPSS version 20.0, using absolute and relative measures, T test for independent samples for measurement comparisons and the Spearman correlation test. In the cognitive evaluation MMSE, those participants with AD present higher risk of cognitive decline (81.8%), greater risk of malnutrition according to MNA (45.5%) and altered levels of leptin (90.9%). Upon performing the comparison analysis between the group with AD and the control group, there existed noteworthy differences between the means for the variables MNA (4.40; BMI95% 2.75 – 6.06), MMSE (10.54; BMI95% 7.09 – 13.99) and doses of HDL (High Density Lipoproteins) (14.53; BMI95% 6.18 – 22.88). As well as differences in the p-value < 0.09 in the leptin doses (11.54; BMI95% (-24.98 – 1.89) and transferrin dose (-72.31; BMI95% -159.48 – 14.84). The Spearman correlation demonstrated that the cognitive decline in the group of senior citizens with AD was strongly associated with nutritional conditions MNA (R 0.484) and the leptin dose (R 0.590). Senior citizens with AD present worse nutritional conditions, cognitive decline and biochemical alterations when compared to senior citizens in the control group. As such, the study demonstrated the need for an integrated healthcare assistance concerning senior citizens with AD.

show abstract

“…Furthermore, oxidation-derived stress in the CNS can lead to the oxidation of LDL-C (ox-LDL) and VLDL (ox-VLDL), which determine cytotoxicity of oxidized forms (Escargueil-Blanc et al, 1994). The incidence (Grossi et al, 2018) of the ε4-allele of the APOE gene is higher in AD patients than in controls, which indicates the importance of genetic factors in AD development.…”

Section: Dyslipidemia In Admentioning

confidence: 99%

Lipids and lipoproteins may play a role in the neuropathology of Alzheimer’s disease

Akyol,

Chou

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

Alzheimer’s disease (AD) and other classes of dementia are important public health problems with overwhelming social, physical, and financial effects for patients, society, and their families and caregivers. The pathophysiology of AD is poorly understood despite the extensive number of clinical and experimental studies. The brain’s lipid-rich composition is linked to disturbances in lipid homeostasis, often associated with glucose and lipid abnormalities in various neurodegenerative diseases, including AD. Moreover, elevated low-density lipoprotein (LDL) cholesterol levels may be related to a higher probability of AD. Here, we hypothesize that lipids, and electronegative LDL (L5) in particular, may be involved in the pathophysiology of AD. Although changes in cholesterol, triglyceride, LDL, and glucose levels are seen in AD, the cause remains unknown. We believe that L5—the most electronegative subfraction of LDL—may be a crucial factor in understanding the involvement of lipids in AD pathology. LDL and L5 are internalized by cells through different receptors and mechanisms that trigger separate intracellular pathways. One of the receptors involved in L5 internalization, LOX-1, triggers apoptotic pathways. Aging is associated with dysregulation of lipid homeostasis, and it is believed that alterations in lipid metabolism contribute to the pathogenesis of AD. Proposed mechanisms of lipid dysregulation in AD include mitochondrial dysfunction, blood–brain barrier disease, neuronal signaling, inflammation, and oxidative stress, all of which lead ultimately to memory loss through deficiency of synaptic integration. Several lipid species and their receptors have essential functions in AD pathogenesis and may be potential biomarkers.

show abstract

OxLDL plasma levels in patients with Alzheimer's disease

Cited by 6 publications

References 22 publications

The Effects of Probiotic Lactobacillus and Bifidobacterium Strains on Memory and Learning Behavior, Long-Term Potentiation (LTP), and Some Biochemical Parameters in β-Amyloid-Induced Rat’s Model of Alzheimer’s Disease

The Effects of Probiotic Lactobacillus and Bifidobacterium Strains on Memory and Learning Behavior, Long-Term Potentiation (LTP), and Some Biochemical Parameters in β-Amyloid-Induced Rat’s Model of Alzheimer’s Disease

Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study

Lipids and lipoproteins may play a role in the neuropathology of Alzheimer’s disease

Contact Info

Product

Resources

About