Oxime therapy and outcomes in human organophosphate poisoning: An evaluation using meta-analytic techniques

Peter, John Victor; Moran, John L.

doi:10.1097/01.ccm.0000198325.46538.ad

Cited by 131 publications

(83 citation statements)

References 42 publications

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“…Assessment of OPC poisoning patients is better done by use of peradeniya organophosphorus poisoning (POP) scale, clinical manifestation and estimation of red blood cell (RBC) cholinesterase. [7][8][9][10] The common nature of poisoning in Bangladesh is suicidal, homicidal and accidental. The method of poisoning varies from country to country and in a single country in different locations.…”

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confidence: 99%

Organophosphorus Compound Poisoning and Its Outcome: Experience from a Teaching Hospital of Bangladeh

Islam

Akter

Hoque³

et al. 2017

Birdem Med J

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Background: Household and agricultural products containing organophosphorus compound (OPC) pesticides are easily available allowing opportunities for easy source of poisoning throughout the world. Bangladesh is no exception. This study was aimed to find out some epidemiological and demographic profile and immediate outcome of OPC poisoning cases.Methods: This cross-sectional study was done at Rajshahi Medical College Hospital from January to December 2007 and consecutively selected 100 patients with OPC poisoning were studied.Results: Half of the patients belonged to age group 16 25 years, 60% were male, 60% were married, 36% were illiterate and 25% were housewives. Suicidal attempt (85%) was the main intention and the commonest cause was familial disharmony (42%). Gastrointestinal (91%) and pupillary (90%) features were predominant. Most (65%) cases received initial treatment at local hospitals within 30 minutes of ingestion of poison and severity was mild. Forty percent patients required less than 50 ampules of atropine and 75% required 0 3 ampules of pralidoxime. Full recovery was achieved in 82% cases, 8% developed intermediate syndrome and 10% died (6/10, 60% within 24 hours of admission). Hospital stay was <5 days in 83.3% casesConclusion: OPC poisoning severity and time lapse between OPC poisoning and hospitalization is an important factor in determining outcome of OPC poisoning.Birdem Med J 2016; 6(2): 74-78

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confidence: 99%

Organophosphorus Compound Poisoning and Its Outcome: Experience from a Teaching Hospital of Bangladeh

Islam

Akter

Hoque³

et al. 2017

Birdem Med J

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“…Intravenous magnesium sulfate decreased poisoning [16][17][18]. The use of "-oximes" has been found to be of no benefit, or possibly harmful, in at least two meta-analyses [19,20]. Several studies try to estimate the role of ACH level and the prognosis of OPP but the results was controversial but these studies confirm that low ACHE associated with longer duration of hospital stay [21][22][23][24].…”

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confidence: 88%

Organophosphate Poisoning and Cholinesterase Level: Case Report

Mansour¹

2016

Med-Science

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“…Bu metabolit karboksilesteraz, butirilkolinesteraz'da olduğu gibi asetilkolinesteraza yüksek affinite ile bağlanmakta ve asetilkolinesterazı inhibe ederek toksik etki göstermektedir (14,39). Canlılarda organofosfatlı pestisitlerin detoksifikasyonu; Paraoksonaz (PON1), asetilkolinesteraz ve karboksilesteraz gibi enzimler tarafından gerçekleştirilmektedir (20,35). PON1 enzimi, parathion, diazinon ve CPF gibi çok sayıda insektisitin toksik okson metabolitlerini ve soman, sarin, tabun gibi organofosfat sinir ajanlarını hidroliz edebilmektedir (25).…”

Section: Introductionunclassified

Akut klorprifos-etil zehirlenmesine karşı kafeik asit fenetil ester’in koruyucu etkisi

KARAPEHLİVAN¹

2015

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Özet: Bu çalışmada organofosfatlı pestisitlerden biri olan klorprifos-etil (CPF) ile akut zehirlenmede kafeik asit fenetil ester (CAPE)'in paraoksonaz (PON1) aktivitesi, oksidatif stres indeksi (OSİ), total antioksidan (TAS) ve total oksidan (TOS) seviyeleri üzerine etkisinin araştırılması amaçlandı. Çalışmada her biri 25-30 g ağırlığında, 32 adet erkek Mus musculus türü fare rastgele 4 eşit gruba ayrıldı. Grup I'e periton içi enjeksiyon ile serum fizyolojik (% 0.9 NaCl); grup II'ye deri altı serum fizyolojik ile 101 mg/kg CPF; grup III'e periton içi 10 μmol/kg CAPE; grup IV'e ise deri altı 101 mg/kg CPF ve periton içi 10 μmol/kg CAPE uygulandı. Elde edilen serum örneklerinde PON1 aktivitesi, OSİ, TAS ve TOS düzeyleri analiz edildi. Çalışmada CPF uygulamalarında, PON1 189.21±22.31 U/L; TAS 1.03±0.13 mmol Trolox eqivalen/L; TOS 7.10±0.69 μmol H 2 O 2 equiv./L ve OSİ değerleri 0.69±0.09 arbitrary birim olarak bulundu. CPF ile oluşturulan intoksikasyonda PON1 aktivitesi ve TAS düzeyleri azalırken, OSİ ve TOS düzeyleri-nin arttığı tespit edildi. CAPE'nin ise, CPF'nin neden olduğu oksidatif stresi azaltarak koruyucu etki gösterdiği belirlendi.Anahtar sözcükler: Kafeik asit fenetil ester, klorprifos-etil, oksidatif stres, paraoksonaz, toplam antioksidan. Protective role of caffeic acid phenethyl ester against to chlorpyrifos-ethyl acute poisoningSummary: The present study aimed to investigate the caffeic acid phenetyl ester (CAPE) effect on levels of paraoxonase (PON1) activity, oxidative stress index (OSI), total antioxidant (TAS) and total oxidant (TOS) levels in acute poisoning of chlorpyrifos-ethyl (CPF). All experiments conducted on 32 male Mus musculus sp. mice divided into 4 equal groups each 25-30 g as following. Group I were treated with saline (% 0.9 NaCl) by intraperitoneal injection (i.p.). Group II with 101 mg/kg CPF plus saline subcutaneously; group III with 10 μmol/kg CAPE intraperitonally; group IV with 101 mg/kg CPF plus 10 μmol/kg CAPE were applied. After serum samples obtained, PON1 activity, OSI, TAS and TOS levels were measured. In this study, PON1 189.21±22.31 U/L; TAS 1.03±0.13 mmol Trolox eqivalen/L; TOS 7.10±0.69 μmol H 2 O 2 equiv./L and OSİ 0.69±0.09 arbitrary unit levels were found during CFP applications. As conclusion, OSI and TOS levels were increased while serum PON1 activity and TAS levels decreased under CPF intoxication compared to group I. Additionally, CAPE was demonstrated the protective effect by reducing CPF-induced oxidative stress.

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Oxime therapy and outcomes in human organophosphate poisoning: An evaluation using meta-analytic techniques

Cited by 131 publications

References 42 publications

Organophosphorus Compound Poisoning and Its Outcome: Experience from a Teaching Hospital of Bangladeh

Organophosphorus Compound Poisoning and Its Outcome: Experience from a Teaching Hospital of Bangladeh

Organophosphate Poisoning and Cholinesterase Level: Case Report

Akut klorprifos-etil zehirlenmesine karşı kafeik asit fenetil ester’in koruyucu etkisi

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