Oxidized to non-oxidized lipoprotein ratios are associated with arteriosclerosis and the metabolic syndrome in diabetic patients

Girona, Josefa; Manzanares, José María; Marimón, Francesc; Cabré, Anna; Heras, Mercedes; Guardiola, Montse; Ribalta, Josep; Masana, Luís

doi:10.1016/j.numecd.2007.04.002

Cited by 48 publications

(37 citation statements)

References 39 publications

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“…Our results showed the association in patients with different durations of diabetes. Ox-LDL (or oxidation ratio of LDL-cholesterol) is reported to have a significant association with diabetes macro-and microvascular complications [6,[19][20][21][22]. Our findings, alongside with the results of the previous studies showing that high plasma ox-LDL levels are predictors of subclinical and clinical atherosclerosis [23][24][25], indicating that controlling ox-LDL level, may prevent the progression of atherosclerotic complications at an early stage.…”

Section: Discussionsupporting

confidence: 78%

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Nakhjavani

Khalilzadeh

Khajeali

et al. 2010

Lipids

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Oxidized low-density lipoprotein (ox-LDL) plays a key role in the progression of atherosclerosis and diabetes complications. The aim of this study was first, to evaluate the association between ox-LDL and diabetes duration, and second, to examine serum level of ox-LDL in patients with prolonged diabetes and a desirable LDL-cholesterol level. A total of 36 type-2 diabetic patients with a diabetes duration of more than 5 years, 36 newly diagnosed diabetic patients, and 36 age-, sex- and BMI-matched healthy participants were recruited. Healthy participants and newly diagnosed patients were not receiving any treatment. All patients with prolonged diabetes had desirable LDL-cholesterol levels (<100 mg/dL), according to the adult treatment panel-III guidelines. While LDL-cholesterol was significantly lower in patients with diabetes duration >5 years, in comparison to newly diagnosed patients (P < 0.01), ox-LDL was significantly higher in patients with prolonged diabetes (P < 0.001). The ox-LDL-to-LDL ratio was dramatically higher in patients with diabetes duration >5 years in comparison to newly diagnosed patients and healthy participants (P < 0.001). Ox-LDL was significantly associated with diabetes duration (r = 0.519, P = 0.001). In multivariate analysis, this association remained significant (beta = 0.501, P = 0.003) after adjustment for potential confounders. In conclusion, this study showed that the serum ox-LDL level increases with the length of diabetes, even though the patients' LDL-cholesterol level is maintained at a desirable level. Our findings highlight that possibly more attention should be focused on markers of oxidative stress in the management of lipids in diabetic patients.

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Section: Discussionsupporting

confidence: 78%

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Nakhjavani

Khalilzadeh

Khajeali

et al. 2010

Lipids

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“…The antioxidant properties of HDL have been well studied and the ratio of oxLDL/β2GPI complexes to HDL-C probably reflects better oxidative stress. Earlier reports suggest that, this ratio imbalance could be a useful marker for atherosclerosis in diabetic patients [12,29]. In the current study, we have found a significant decrease in the oxLDL/ β2GPI complexes to HDL-C ratio after HRT.…”

Section: Discussionsupporting

confidence: 73%

“…However, there was no statistically significant change in the oxLDL/β2GPI complexes level (3%, P=0.30) in response to HRT. The ratio of oxLDL/ β2GPI to HDL-C which expresses lipoprotein oxidative status [12], were calculated in each case. The oxLDL/β2GPI to HDL-C ratio was significantly lower in samples obtained after HRT (P= 0.018, Fig.…”

Section: Resultsmentioning

confidence: 99%

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

et al. 2010

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“…Indeed, ROS and endoplasmic reticulum stress can induce kappa B kinase beta to activate NFߢB, thereby stimulating the ROS, TNF-α and IL-6 are known to inhibit adiponectin (Hosogai et al 2007). The levels of C-reactive protein, TNF, IL-6, IL-18 and oxidized LDL are increased in obese subjects with metabolic syndrome (Girona et al 2007;Van Guilder et al 2006). …”

Section: Fructose and Inflammationmentioning

confidence: 99%

Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation

Bernardes

Ayyappan

Angelis

et al. 2017

Can. J. Physiol. Pharmacol.

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https://mc06.manuscriptcentral.com/cjpp-pubs AbstractA rapid rise in obesity as well as physical inactivity in industrialized countries is associated with fructose consumption-mediated metabolic syndrome having a strong association with cardiovascular disease. Although insulin resistance is thought to be at the core, visceral obesity, hypertension and hypertriglyceridemia are also considered important components of this metabolic disorder. In addition, various other abnormalities such as inflammation, oxidative stress and elevated levels of uric acid are also part of this syndrome. Life style changes through improved physical activity as well as nutrition are important approaches to minimize the metabolic syndrome and its deleterious effects.

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Oxidized to non-oxidized lipoprotein ratios are associated with arteriosclerosis and the metabolic syndrome in diabetic patients

Cited by 48 publications

References 39 publications

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation

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