Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation

Abstract

https://mc06.manuscriptcentral.com/cjpp-pubs AbstractA rapid rise in obesity as well as physical inactivity in industrialized countries is associated with fructose consumption-mediated metabolic syndrome having a strong association with cardiovascular disease. Although insulin resistance is thought to be at the core, visceral obesity, hypertension and hypertriglyceridemia are also considered important components of this metabolic disorder. In addition, various other abnormalities such as inflammation, oxidative stress and elevated levels of uric acid are also part of this syndrome. Life style changes through improved physical activity as well as nutrition are important approaches to minimize the metabolic syndrome and its deleterious effects.

Metabolic syndrome susceptibility of suckling male and female rats given oral administration of natural honey compared with cane syrup

“…The results suggested that the experimental animals in this study were exposed to sub-adverse levels of refined sugar, as several previous studies [1][2][3][4][5][6] have associated high sugar intake with hyperglycaemia and hypertriglyceridemia. Male rats are not known to be resistant to abdominal obesity, hyperglycaemia, dyslipidaemia and other risk factors of renal and metabolic diseases.…”

“…Children are also not spared from the scourge of MetS due to their high intake of sugars as reported by [5] [6]. The intake of refined sugars had risen in recent times [4] [5], especially fructose due to the cheaper cost of production of HFCS relative to sucrose as reported by [4]. The manufacturers of beverages and other carbonated-water products now sweetened their products with the cheaply produced HFCS as observed elsewhere [4] in a bid to safe cost.…”

“…The intake of refined sugars had risen in recent times [4] [5], especially fructose due to the cheaper cost of production of HFCS relative to sucrose as reported by [4]. The manufacturers of beverages and other carbonated-water products now sweetened their products with the cheaply produced HFCS as observed elsewhere [4] in a bid to safe cost. However, this reduction in production cost was not devoid of another price as it has been noted by some researchers .…”

“…Several studies have implicated the consumption of sucrose and fructose including high fructose corn syrup (HFCS) in the epidemiology and pathogenesis of metabolic syndrome, MetS [1][2][3][4][5][6], a group of risk factors that predispose people to diabetes, renal and metabolic diseases [1]. Children are also not spared from the scourge of MetS due to their high intake of sugars as reported by [5] [6].…”

Phenolic acids alleviate high-fat and high-fructose diet-induced metabolic disorders in rats

“…Moreover, it is associated with hepatic insulin resistance, increased visceral fat mass, and accumulation of ectopic fat in the liver and skeletal muscle (Tappy, Lê, Tran, & Paquot, ). It has also been proved to cause mitochondrial dysfunction as well as cardiometabolic dysfunction through oxidative stress and inflammation (Bernardes et al, ; Jaiswal et al, ). Therefore, in the present study, high‐fat combined with high‐fructose diet (HFFD) was used to induce MS in rats, which closely mimics the natural pathogenic process of MS in human.…”