Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease

Abstract

Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol, high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method, HDL cholesterol by phosphotungstate precipitation method. Serum levels of LDL fraction of cholesterol was measured by a new and simpler method of precipitation. Result was expressed as mol/L of diene conjugates. It was observed that LDL cholesterol, VLDL cholesterol, total cholesterol, total cholesterol:HDL cholesterol, LDL cholesterol:HDL cholesterol were significantly raised and HDL cholesterol was significantly low in patients. (p< 0.001). Though HDL cholesterol was significantly raised in females as compared to males in both the groups (p<0.001). Serum level of total cholesterol, oxidized LDL:HDL cholesterol were also raised significantly (p<0.05). The level of oxidized LDL showed an increasing trend in patients.

Weight reduction with improvement of serum lipid profile and ratios of Sesamum radiatum leaves diet in a non-obese Sprague Dawley rats

“…This significant reduction in TG levels may be attributed to an increasing lipid peroxidation activity (LPL), which will lead to an increase in the degredation of TG and/or reduction in VLDL which is usually produced in the liver and aids in lipolytic removal of TG-rich lipoproteins from the circulation (Wang et al, 2003;Megalli et al, 2006). Studies have shown that elevated VLDL-C is associated with a high TG, since VLDL-C carries the highest amount of TG in the body (Ghosh et al, 2006) as observed in this study.…”

Oxidative Stress, Endogenous Antioxidant and Ischemia-modified Albumin in Normolipidemic Acute Myocardial Infarction Patients

“…[3][4][5][6][7][8][9][10] Lowering of high-density lipoprotein (HDL)-cholesterol (HDL-C) is a common phenomenon observed in myocardial infarction (MI) patients. [3][4][5][6][7][8][9][10] Elevated Low density lipoprotein (LDL)-cholesterol (LDL-C) is considered the most important risk factor for CAD and its oxidation plays a central role in atherogenesis. Subendothelial accumulation of foam cells initiates the process of atherosclerosis.…”

Cardiovascular Risk Factors in Elderly Normolipidaemic Acute Myocardial Infarct Patients

“…Literature survey reveals dyslipidaemic subjects are more prone to myocardial infarction, due to increased free radical generation and ischemia as it is a conventional risk factor. (Malhotra et al, 2003;Mishra et al, 2005;Ghosh et al, 2006;Patil et al, 2007;Rajasekhar et al, 2004;Rani et al, 2005;Gomez et al,1996). Lowering of high density lipoprotein-cholesterol (HDL-C) is a common phenomenon observed in MI patients supported by previous studies (Malhotra et al, 2003;Mishra et al, 2005;Ghosh et al, 2006;Patil et al, 2007;Rajasekhar et al, 2004;Rani et al, 2005).…”

“…(Malhotra et al, 2003;Mishra et al, 2005;Ghosh et al, 2006;Patil et al, 2007;Rajasekhar et al, 2004;Rani et al, 2005;Gomez et al,1996). Lowering of high density lipoprotein-cholesterol (HDL-C) is a common phenomenon observed in MI patients supported by previous studies (Malhotra et al, 2003;Mishra et al, 2005;Ghosh et al, 2006;Patil et al, 2007;Rajasekhar et al, 2004;Rani et al, 2005). High density lipoprotein-cholesterol (HDL-c) is the most important independent protective factor for arteriosclerosis which underlies coronary heart disease (CHD).…”