Oxidative Stress Status During Exposure to Propofol, Sevoflurane and Desflurane

Allaouchiche, Bernard; Debon, Richard; Goudable, J.; Chassard, D.; Duflo, Frédéric

doi:10.1097/00000539-200110000-00036

Cited by 135 publications

(107 citation statements)

References 17 publications

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“…This is not consistent with our results, perhaps due to a different experimental design, as we did our research on rats and we did not mechanically ventilate them as Allaochiche et al (26) did with swine. Our experimental design, which included controlled breathing environment and a relatively long time of exposure (4 hours), aimed to underline the relation between volatile anaesthetics and oxidative stress.…”

Section: Discussioncontrasting

confidence: 89%

“…In swine lungs, desfl urane seemed to induce local and systemic oxidative stress, whereas sevofl urane showed antioxidative properties (26). This is not consistent with our results, perhaps due to a different experimental design, as we did our research on rats and we did not mechanically ventilate them as Allaochiche et al (26) did with swine.…”

Section: Discussioncontrasting

confidence: 72%

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Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

Türkan

Aydın

Sayal

et al. 2011

Archives of Industrial Hygiene and Toxicology

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General anaesthetics are often used in patients who are under oxidative stress due to a critical illness or surgical trauma. Some anaesthetics may worsen oxidative stress and some may act as antioxidants. The aim of this study was to evaluate liver, brain, kidney, and lung tissue oxidative stress in rats exposed to desfl urane and sevofl urane and in unexposed rats. The animals were divided in three groups: control (received only air); sevofl urane (8 %), and desfl urane (4 %). After four hours of exposure, we evaluated the levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), Cu, and Zn. Exposure to either of the anaesthetics signifi cantly increased lung MDA levels compared to control (Mann-Whitney U test; P<0.05), probably because it is the tissue directly exposed to anaesthetic gases. Oxidative stress and antioxidant activity in other tissues varied between the desfl urane and sevofl urane groups. Our results suggest that anaesthesiologist should not only be aware of the oxidative or antioxidative potential of anaesthetics they use, but should also base their choices on organs which are the most affected by their oxidative action.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussioncontrasting

confidence: 72%

Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

Türkan

Aydın

Sayal

et al. 2011

Archives of Industrial Hygiene and Toxicology

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“…By corroborating these aspects, it can be concluded that the postischemic contractile dysfunctions are being reduced. [16][17][18][19][20] This refers to the fact that short periods of ischemia, with a duration small enough not to produce cardiomyocyte necrosis, alternated with reperfusion, offers myocardial protection against an infarction produced by an ulterior prolonged ischemia, called in the specialized literature ischemia "test" or ischemia "index". 2,11,[21][22][23][24][25] In this paper, we present a study regarding the effects of two volatile anesthetic agents, Isoflurane and Sevoflurane on the heart, in situ, by using laboratory animals in which brain death was induced.…”

mentioning

confidence: 99%

Cardioprotective Effects Induced by Preconditioning with Halogenated Anesthetics

Păpurică¹,

Săndesc²,

Rogobete³

et al. 2016

Journal of Interdisciplinary Medicine

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backgroundIn the organ transplantation field, a very intense and important topic is to find ways to increase the quality of organs that are taken from willing donors, in order to improve the recovery capacity of the transplant recipients. 1 From the moment of the organ removal until its actual transplantation, there is a variable period of ischemia, named cold-ischemia, responsible for the production Cardioprotective Effects Induced by Preconditioning with Halogenated AnestheticsMarius Papurica 1,2 , Dorel Sandesc 1,2 , Alexandru Florin Rogobete 1,2 , Radu Nartita 3 , Corina Vernic 2 , Sonia Elena Popovici 2 , Ovidiu Horea Bedreag 1,2 1 Clinic of Anesthesia and Intensive Care, "Pius Brinzeu" Emergency County Hospital, Timișoara, Romania 2 Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania 3 Faculty of Chemistry, Biology, Geography, West University of Timișoara, Romania ABSTRACT Background: Numerous studies discuss the protective effects of halogenated anesthetics on myocyte injury induced by the ischemia-reperfusion syndrome of the heart. This mechanism is known as pharmacological preconditioning. Aim of the study: The objective of this study was to identify the effects of two volatile anesthetics frequently used in current clinical practice, Isoflurane and Sevoflurane, on the in situ heart. The study was performed on laboratory animals with induced brain death. Material and methods: The animals were divided into 3 groups, the control group (n = 8), IZO-PRE group (n = 8) and SEVO-PRE group (n = 8), on which the experimental protocol established for this study was applied. From a molecular point of view, the expressions of protein kinase C-epsilon (PKCε) and of glycogen synthase kinase -3 beta (GSK-3β) were investigated. Results: Following the statistical analysis, we observed a significant reduction in the size of the infarcted area in the IZO-PRE group compared to the control group (p <0.0001). Regarding the SEVO-PRE group, no reduction was observed (p >0.05). The expression of GSK-3β is more pronounced in case of the SEVO-PRE group, at 5 minutes after reperfusion, and the effect disappears after 15 minutes. The expression of PKCε as a total form of the enzyme, occurs at 5 minutes after reperfusion in the SEVO-PRE group and late in the IZO-PRE group (after 15 minutes). Conclusions: Both anesthetics that were applied showed a cardioprotective effect. Isoflurane provided a better structural and morphological protection, but Sevoflurane resulted in a more effective protection in terms of functionality, significantly reducing the incidence of extremely severe life-threatening arrhythmias.

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“…In earlier studies with various methodologies, propofol has been shown to cause OS (oxidative stress), not to affect OS, or to have antioxidant effect (26)(27)(28)(29). In in vitro studies, it has been shown to inhibit lipid peroxidation induced by oxidative stress in the liver microsomes, mitochondria, and brain synaptosomes (30).…”

mentioning

confidence: 99%

Investigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced

Fm¹,

Öztürk²,

Alkan³

et al. 2014

BLL

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Abstract:Purpose: In the current study we aim to investigate the effects of vitamin C and profol on red blood cell deformability in diabetic rats Materials and methods: Twenty-eight Wistar Albino rats were included in the study after streptozocin (60 mg/ kg) treatment for 4 weeks of observation for diabetes presence. Twenty-eight rats were allocated to 4 groups. In group DP (n = 7) 150 mg.kg -1 of propofol was injected intraperitoneally. In group DP-vit C (n = 7) rats 100 mg/kg of vitamin C (Ascorbic acid, Redoxon ® 1000 mg/5 mL -Roche) were applied one hour before administrating 150 mg.kg -1 of propofol, while rats in control group (n = 7), and diabetic control group (n = 7) received intraperitoneally physiological saline. Deformability measurements were achieved by using erythrocyte suspensions with hematocrit level of 5 % in PBS buffer. Results: Erythrocyte deformability was signifi cantly higher in diabetic control group than in control and vitamin C plus propofol groups (p = 0.00, p = 0.025, respectively). Erythrocyte deformability indexes were found similar in control group and vitamin C plus propofol group (p = 0.949). Relative resistance was increased in diabetic rat model. Conclusions: Erythrocyte deformability was damaged in rats with diabetes. This injury might lead to further problems in microcirculation. Application of propofol did not alter red cell deformability in diabetic rats. Vitamin C supplementation seems to reverse those negative effects and variations in erythrocyte deformability (Fig. 2

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Oxidative Stress Status During Exposure to Propofol, Sevoflurane and Desflurane

Cited by 135 publications

References 17 publications

Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

Cardioprotective Effects Induced by Preconditioning with Halogenated Anesthetics

Investigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced

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