Oxidative Stress Reduction (Prong-3)

DePace, Nicholas L.; Colombo, Joseph

doi:10.1007/978-3-030-17016-5_5

Cited by 1 publication

(1 citation statement)

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“…It is plausible to believe that Nrf2 activation minimises the deleterious effects of ROS on inflamed tissue cells and, ultimately, inflammation. 50 Furthermore, the idea that NLR family pyrin domain containing 3 (NLRP3) inflammasome activation is controlled by ROS and oxidative stress provides an even more straightforward explanation for Nrf2 signalling anti-inflammatory action. 51 As a result, multiple studies have been published since the introduction of the hypothesis that ROS regulates NLRP3 inflammasome activation, demonstrating a link between Nrf2 activation and NLRP3 inflammasome suppression in many different disease models associated with inflammation.…”

Section: Nrf2 Activation and Inflammasome Inhibitionmentioning

confidence: 99%

The Promotion of Antioxidant and Anti-Inflammatory Activity by Nrf2 Amplifier is A Potential Technique in Diabetic Wound Healing — A Review

et al. 2022

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Wound healing is a complicated organised process that includes numerous phases that connect diverse cellular events and activate several intracellular molecular pathways in injured cells and tissues. Delay in wound healing owing to high levels of oxidative stress is a major difficulty in various metabolic illnesses, including diabetes mellitus. Several therapeutic wound dressing materials and methods, such as hyperbaric oxygen treatment and negative pressure wound therapy, have been developed to speed up wound healing and restore cellular homeostasis. A significant advance has been made in locating transcriptional regulators involved in wound healing. The redox sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is the major regulator of antioxidant defense regulation, inducing the expression of cyto-protective genes and increasing the generation of antioxidants that scavenge free radicals.Activators of Nrf2 have been shown to reduce oxidative stress and improve wound healing in a variety of pathophysiological situations, including diabetes and its consequences such as diabetic foot ulcers, chronic kidney disease, and diabetic nephropathy. Several therapeutic chemicals have been discovered to alleviate oxidative stress and consequently increase cell proliferation. Angiogenesis results in tissue healing through activating the transcription factor Nrf2. This review focuses on role of Nrf2 mediated antioxidant gene expression for diabetic wound healing.

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Section: Nrf2 Activation and Inflammasome Inhibitionmentioning

confidence: 99%