Oxidative stress parameters in patients with slow coronary flow

Enli, Yaşar; Türk, Mehmet Sezai; Akbay, Ramazan; Evrengül, Harun; Tanrıverdi, Halil; Kuru, Ömür; Şeleci, Deniz; Kaftan, Asuman; Öztekin, Özer; Enli, Havane

doi:10.1007/s12325-008-0011-4

Cited by 34 publications

(21 citation statements)

References 27 publications

(30 reference statements)

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“…2 The exact etiopathogenesis of SCF is unclear, but several mechanisms have been proposed including enhanced oxidative stress and inflammation, microvascular dysfunction, small vessel disease, impaired endothelial functions, and diffuse atherosclerosis. [3][4][5][6][7] However, the role of inflammation, oxidative stress, and endothelial dysfunction in the pathogenesis of SCF is well established. 5,8,9 Macrophages and monocytes are the most important cell types for secretion of proinflammatory and prooxidant cytokines at the site of inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7] However, the role of inflammation, oxidative stress, and endothelial dysfunction in the pathogenesis of SCF is well established. 5,8,9 Macrophages and monocytes are the most important cell types for secretion of proinflammatory and prooxidant cytokines at the site of inflammation. 10 In addition, high-density lipoprotein cholesterol (HDL-C) has been shown to defend endothelial cells against the unfavorable effects of low-density lipoprotein (LDL) 11,12 and to prohibit oxidation of LDL molecules.…”

Section: Introductionmentioning

confidence: 99%

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Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation

Canpolat

Çetin

et al. 2015

Clin Appl Thromb Hemost

188

165

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation

Canpolat

Çetin

et al. 2015

Clin Appl Thromb Hemost

188

165

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“…Nevertheless, the histopathological characteristics are similar to coronary atherosclerosis and microvascular dysfunction and free radical damage may be responsible for the pathology (1,7,23). Previous studies reported significantly increased intima-media thickness (IMT) of the carotid artery which is known as a marker of subclinical atherosclerosis in patients with SCF (24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, human (31) and animal (32) studies have shown decreased levels of TAS in cases with acute myocardial infarction. Enli et al (23) reported elevated parameters of oxidative stress in patients with SCF compared to control group.…”

Section: Discussionmentioning

confidence: 99%

Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study

Koç

Erdem²,

Altunkaş³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Yavaş koroner akım (YKA) önemli darlık olmaksızın epikardiyal koroner arterlerin geç opasifiye olmasıdır. Yavaş koroner akım oluşumundaki temel mekanizma koroner ateroskleroza benzer ve serbest radikal oluşumu patolojiden sorumlu olabilir. Biz bu çalışmada, normal koroner arterli hastalarla, daralma olmaksızın YKA bulunan hastalar arasında iskemi-modifiye albümin (İMA) seviyeleri ve total antioksidan durum (TAD) açısından farklılık olup olmadığını araştırdık. Yöntemler: Koroner anjiyografi sırasında YKA bulunan 30 ardışık hasta (13 erkek; ortalama yaş 56±10 yıl) ile normal koroner artere sahip olup YKA olmayan 30 kişi (13 erkek; ortalama yaş 53±11 yıl) kontrol grubu olarak bu gözlemsel enine-kesitli çalışmaya alındı. Bu çalışmada serum İMA seviyeleri, albümine göre düzeltilmiş İMA ve TAD ölçüldü. İki grup arasında serum İMA seviyeleri ve TAD'ı değerlendirmek için Student t-testi kullanıldı. Serum İMA seviyeleri ve TAD arasındaki ilişkiyi açıklamak için Pearson korelasyon testi uygulandı. Bulgular: Serum İMA seviyeleri ve albümine göre düzeltilmiş İMA her iki grupta benzerdi (p=0.432, p=0.349). Ortalama TAD değeri YKA grubunda kontrol grubuna göre daha düşük bulundu (p=0.011). Yavaş koroner akım hastalarında TAD ile serum İMA seviyeleri ve albümine göre düzeltilmiş İMA arasında negatif ilişki tespit edildi (r=-0.457, p=0.011; r=-0.509, p=0.004). Sonuç: Bu çalışma göstermiştir ki, serum İMA seviyeleri ve albümine göre düzeltilmiş İMA gruplar arasında benzerken, ortalama TAD değeri YKA grubunda kontrol grubundan daha düşük ve İMA ile negatif olarak ilişkilidir. Bu sonuçlar YKA patofizyolojisini anlamak için önemli bulunmuştur. (Anadolu Kardiyol Derg 2011; 11: 582-7) Anahtar kelimeler: Antioksidan durum, iskemi-modifiye albümin, yavaş koroner akım ABSTRACT Objective: Slow coronary flow (SCF) is defined as late opacification in the epicardial coronary arteries without significant stenosis. The underlying mechanism of SCF is similar to coronary atherosclerosis. Free radical damage may be responsible for the pathology. In this study, we aimed to investigate ischemia-modified albumin (IMA) levels and differences with regard to total antioxidant status (TAS) between patients with normal coronary arteries and patients with SCF without significant stenosis. Methods: Thirty patients who were diagnosed with SCF using coronary angiography were included in this cross-sectional observational study (13 male; mean age, 56±10 years). The control group consisted of 30 patients who had normal coronary arteries as shown by coronary angiography (13 male; mean age, 53±11 years). In this study, we assessed serum IMA levels, albumin-adjusted IMA and TAS. The Student t-test was used to compare serum IMA levels and TAS between the two groups. Pearson's correlation test was used to explore the relationship between TAS and serum IMA levels. Results: Serum IMA levels and albumin-adjusted IMA were similar in both groups (p=0.432, p=0.349). The mean value of TAS was significantly lower in the SCF group compared to control group (p=0.0...

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“…However, similar to OSA, endothelial dysfunction, [20][21][22] oxidative stress, insulin resistance and microvascular dysfunction have been suggested as underlying mechanisms. [23][24][25][26][27][28][29][30][31][32][33][34][35] In addition to these similarities, obesity with or without insulin resistance and lower concentrations of adiponectin and leptin, a hormone involved in the control of body weight and sympathetic nerve activity, have also been found more frequently in both CSFP and OSA. 36 Relationship between the severity of apnea-hypopnea index (AHI) and mean TIMI frame count (TFC).…”

Section: Discussionmentioning

confidence: 99%

Association of sleep apnea with coronary slow-flow phenomenon

Özeke

Gungor

Ertan

et al. 2012

Journal of Cardiovascular Medicine

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Oxidative stress parameters in patients with slow coronary flow

Abstract: Our data showed that in patients with SCF, serum MDA and erythrocyte SOD levels were increased while erythrocyte GSH levels were decreased significantly, compared with NCF patients. These results indicate that free-radical damage may play a role in the pathogenesis of SCF.

Cited by 34 publications

References 27 publications

Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation

Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation

Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study

Association of sleep apnea with coronary slow-flow phenomenon

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