Oxidative Stress, Oogenesis and Folliculogenesis

Paine, Malcolm A.; Ruder, Elizabeth H.; Hartman, Terryl J.; Blumberg, Jeffrey B.; Goldman, Marlene B.

doi:10.1007/978-1-62703-041-0_4

Cited by 4 publications

(2 citation statements)

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“…Thus, maintaining an equilibrium between ROS and antioxidants is paramount during folliculogenesis. 57,58…”

Section: Oxidative Stress In Folliculogenesismentioning

confidence: 99%

Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants

Dutta,

Sengupta,

Izuka

et al. 2024

JIST

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Oxidative stress (OS), caused by an imbalance between oxidants and antioxidants in the body, is pivotal in influencing female reproductive health. This review explores the complex interactions of oxidizing agents and antioxidants on female reproductive functions, underscoring their impact on fertility, pregnancy, and reproductive outcomes. Primarily resulting from excessive reactive oxygen species (ROS), OS can detrimentally affect oocyte maturation, embryonic development, and endometrial receptivity. Although ROS naturally arise during cell metabolism, their overproduction or insufficient neutralization can damage cellular macromolecules, including lipids, proteins, and DNA. Such disruptions can lead to ovarian issues, recurrent pregnancy losses, and conditions like endometriosis and polycystic ovary syndrome (PCOS). Conversely, antioxidants combat excess ROS, promoting cellular balance and reproductive success. Emerging treatments underscore the benefits of boosting antioxidant levels to address OSrelated disorders. However, caution is essential due to potential risks of excessive antioxidant intake. The review underscores the critical association between OS and female reproduction, suggesting therapeutic strategies for improved reproductive outcomes.

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“…Thus, maintaining an equilibrium between ROS and antioxidants is paramount during folliculogenesis. 57,58…”

Section: Oxidative Stress In Folliculogenesismentioning

confidence: 99%

Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants

Dutta,

Sengupta,

Izuka

et al. 2024

JIST

View full text Add to dashboard Cite

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“…Other factors such as nutrient intake and free radicals. Pregnancy increases oxidative stress due to high metabolic activity, characterized by increased placental lipid peroxide and decreased expression of antioxidant enzymes 11 . Soybean tempeh is one of the foods that have been consumed for generations.…”

Section: Introductionmentioning

confidence: 99%

Administration of Tempehethanol Extract on Prenatal Until Weaning Period Inhibit the Ovary Follicles Developing of Little Wistar Rats

Budiani¹,

Somoyani²,

Marhaeni³

et al. 2018

Ind. Jour. of Publ. Health Rese. & Develop.

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Background and objective: soybean tempeh contains isoflavones that are able to bind to estrogen receptors, so they have estrogenic properties. This study aims to prove that the administration of tempeh soybean extract during periods of perception can inhibit the formation of ovarian follicles. Method: posttest only control group design, using female rats aged 12-13 weeks with BB 150 g, a research site in Udayana University's integrated laboratory. Result: the results showed that there were significant differences in the mean number of follicles in the three groups, namely primordial, primary, secondary was p <0.01; atreticfollicles wasp <0.05. Conclusion: the administration of ethanol extract of tempeh during the perimenopause period can inhibit the formation of primordial follicles, primary follicles, and secondary follicles. High doses can increase the average number of atretic follicles.A large number of stimulated follicles grows and subsequently develops atresia, causing fewer primordial follicle reserves 9 . The process of apoptosis is controlled

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