Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging

Paradies, Giuseppe; Petrosillo, Giuseppe; Paradies, Valeria; Ruggiero, Francesca

doi:10.1016/j.freeradbiomed.2010.02.020

Cited by 158 publications

(105 citation statements)

References 160 publications

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“…Among the variety of lipids and proteins constituting mitochondrial membranes, cardiolipins have a high affinity with a large number of proteins and thus play a central role in the structural organization of mitochondrial membranes (Schlame and Ren 2009). Then, an increase in the proportion of cardiolipins in the inner mitochondrial membrane is thought to help better regulating the proton gradient and to lessen ROS production (Hoch 1998;Paradies et al 2010;Schlame and Ren 2009). Accordingly, our correlative analyses show that the production of superoxide per RBC is strongly and significantly decreasing with increasing cardiolipin content per RBC (r = −0.63; Table 2).…”

Section: Modelmentioning

confidence: 99%

“…Cardiolipins can also act as proton trap for ATP phosphorylation (Haines and Dencher 2002), induce ROS-derived release of cytochrome c and activate the mitochondrial transition pore inducing cell apoptosis (Petrosillo et al 2003). Because cardiolipins can have important effects on mitochondrial bioenergetics and ROS production (Paradies et al 2010;Schlame et al 2000), variation in cardiolipin content may explain part of the variation in ROS production and, potentially, variation in lifespan. Interestingly, it has recently been shown that longer-lived tropical bird species have less cardiolipin content per cell than shorter-lived temperate bird species do (Calhoon et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds

Delhaye

Salamin

Roulin

et al. 2016

AGE

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Mitochondrial respiration releases reactive oxygen species (ROS) as by-products that can damage the soma and may in turn accelerate ageing. Hence, according to "the oxidative stress theory of ageing", longer-lived organisms may have evolved mechanisms that improve mitochondrial function, reduce ROS production and/or increase cell resistance to oxidative damage. Cardiolipin, an important mitochondrial innermembrane phospholipid, has these properties by binding and stabilizing mitochondrial inner-membrane proteins. Here, we investigated whether ROS production, cardiolipin content and cell membrane resistance to oxidative attack in freshly collected red blood cells (RBCs) are associated with longevity (range 5-35 years) in 21 bird species belonging to seven Orders. After controlling for phylogeny, body size and oxygen consumption, variation in maximum longevity was significantly explained by mitochondrial ROS production and cardiolipin content, but not by membrane resistance to oxidative attack. RBCs of longer-lived species produced less ROS and contained more cardiolipin than RBCs of shorter-lived species did. These results support the oxidative stress theory of ageing and shed light on mitochondrial cardiolipin as an important factor linking ROS production to longevity.

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Section: Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds

Delhaye

Salamin

Roulin

et al. 2016

AGE

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“…A weak, direct carcinogenic effect of HCV core protein might coordinate with oxidative stress, chronic inflammation and damage to apoptosis regeneration cycle DNA to result in hepatocarcinogenesis at a more advanced age than patients with HBVrelated infection [70] . Oxidative stress is associated with aging that also drives hepatocarcinogenesis in patients with HCV related HCC [71] . Serum markers and hepatocyte deposition associated with iron especially in lysosomes are frequently elevated in patients with chronic hepatitis C infection [72] .…”

Section: Mechanisms Of Hbv-related Hcc and Oxidative Stress Involvementmentioning

confidence: 99%

Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful?

Takaki

Yamamoto

2015

WJH

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stress, causing a high rate of hepatocarcinogenesis among patients with cirrhosis. Non-alcoholic steatohepatitis is also associated with oxidative stress although its hepatocarcinogenic potential is lower than that of chronic hepatitis C. Analyses of serum markers and histological findings have shown that hepatocellular carcinoma correlates with oxidative stress and experimental data indicate that oxidative stress increases the likelihood of developing hepatocarcinogenesis. However, the results of antioxidant therapy have not been favorable. Physiological oxidative stress is a necessary biological response, and thus adequate control of oxidative stress and a balance between oxidative and anti-oxidative responses is important. Several agents including metformin and L-carnitine can reportedly control mechanistic oxidative stress. This study reviews the importance of oxidative stress in hepatocarcinogenesis and of control strategies for the optimal survival of patients with CLD and hepatocellular carcinoma. Core tip: Oxidative stress is a key biological response that correlates with the progression of chronic liver disease. However, oxidative stress is an essential survival mechanism and thus to erase it is an unsuitable approach to disease control. As hepatocarcinogenesis is closely associated with increased oxidative stress via viral proteins or chronic inflammation and lipids, controlling oxidative stress should be effective against progressive liver disease. Agents that can control oxidative stress might represent a more effective approach than reactive oxygen species-scavenging agents. AbstractOxidative stress is becoming recognized as a key factor in the progression of chronic liver disease (CLD) and hepatocarcinogenesis. The metabolically important liver is a major reservoir of mitochondria that serve as sources of reactive oxygen species, which are apparently responsible for the initiation of necroinflammation. As a result, CLD could be a major inducer of oxidative stress. Chronic hepatitis C is a powerful generator of oxidative REVIEWSubmit a

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“…No entanto, quando há uma quantidade maior de oxidantes em relação aos antioxidantes, o organismo fica vulnerável aos efeitos deletérios das espécies reativas e a inúmeros distúrbios metabólicos e fisiológicos. A essa condição dá-se o nome de estresse oxidativo [15][16][17][18][19][20].…”

Section: Estresse Oxidativo Síndrome Metabólica E Alterações Vascularesunclassified

Aspectos oxidativos da síndrome metabólica e aterosclerose

Barbalho¹,

Quesada²,

Goulart³

et al. 2015

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. http://creativecommons.org/licenses/by/4.0/deed.pt_BR Aspectos oxidativos da síndrome metabólica e aterosclerose ABStRActAims: To review the literature on the current aspects of oxidative stress and its role in metabolic syndrome and in atherosclerosis. Methods:The study was performed in April and May 2015 and the following databases were used: PubMed, SciELO, and LILACS, including articles published from 2011 onwards. The following keywords were used: oxidative stress and atherosclerosis or oxidative stress and metabolic syndrome. Meta-analyses and clinical trials with a large sample size were preferred. Results: A total of 3,934 articles were available in the databases (PubMed 3,292; SciELO 588; and LILACS 54). Fifty-three articles were included in the review after eliminating double references and using the inclusion criteria. Conclusions: Biochemical and anthropometric findings characteristic of the metabolic syndrome are related to inflammatory processes and to oxidative stress which, in turn, are closely related to atherosclerosis. A better understanding of how the conditions that underlie metabolic syndrome predispose to oxidative stress may significantly contribute to the treatment of patients with cardiovascular disease in the future.KEY WORDS: metabolic syndrome x; oxidative stress; atherosclerosis.

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Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging

Cited by 158 publications

References 160 publications

Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds

Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds

Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful?

Aspectos oxidativos da síndrome metabólica e aterosclerose

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