Oxidative Stress Measured by Urine F2-Isoprostane Level is Associated With Prostate Cancer

Barocas, Daniel A.; Motley, Saundra; Cookson, Michael S.; Chang, Sam S.; Penson, David F.; Dai, Qi; Milne, Ginger L.; Roberts, L. Jackson; Morrow, Jason D.; Concepcion, Raoul S.; Smith, Joseph A.; Fowke, Jay H.

doi:10.1016/j.juro.2011.02.020

Cited by 76 publications

(56 citation statements)

References 30 publications

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“…8, 9, 11 However, inconsistent with above studies, several cross-sectional studies collected blood samples after prostate cancers were diagnosed, and found that participants with prostate cancer had higher levels of F2-Isoprostane, malondialdehyde by thiobarbituric acid assay, and lower activities of superoxide dismutase and glutathione peroxidase than those without prostate cancer. 10, 12, 34, 35 Therefore, elevated oxidative stress in patients with prostate cancer in the above cross-sectional studies is likely to be the outcome of the prostate cancer or its comorbidities. High level of oxidative stress is unlikely considered to be an etiologic factor for prostate cancer incidence.…”

Section: Discussionmentioning

confidence: 99%

Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study

Yang

Pinney

Mallick

et al. 2015

Clinical Genitourinary Cancer

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Introduction Biomarkers of oxidative stress and advanced glycation end products (AGE) have been linked to the development of prostate cancer, but evidence from human studies is either scarce or controversial. Materials and Methods We conducted a prospective nested case-control study among 48 men (24 prostate cancer cases and 24 controls) aged 48–76 years at baseline. The participants of our study were a part of the Fernald Community Cohort (FCC). Prostate cancer cases and controls were matched individually on age (± 3 years) with 1:1 ratio. Biomarkers included urine F2-isoprostanes (markers of lipid oxidation), plasma fluorescent oxidation products (FlOPs; markers of global oxidation) and carboxymethyllysine (CML; a major end-stage AGE). Results At baseline, cases had similar age, body mass index, proportion of family history of prostate cancer, history of benign prostatic hyperplasia, history of hypertension, history of diabetes, smokers and plasma glucose levels as compared to controls. Levels of plasma CML were significantly higher in cases than in controls (182 vs. 152 μg/ml, P < 0.05). In the conditional logistic regression model, an increase in CML equivalent to one standard deviation was associated with increased risk of incident prostate cancer (Relative risk = 1.79, 95% confidence interval = 1.00–3.21), and accounted for ~8% variance of prostate cancer liability. Urine F2-isoprostanes and plasma FlOPs were not associated with prostate cancer incidence. Conclusion Higher levels of plasma CML were associated with increased risk of prostate cancer. This suggests a potential new pathway for prostate cancer prediction and treatment.

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Section: Discussionmentioning

confidence: 99%

Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study

Yang

Pinney

Mallick

et al. 2015

Clinical Genitourinary Cancer

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“…We included 238 adults with AMD and 390 age-and sex-matched controls without AMD who participated in a population-based cross-sectional study in Singapore (Singapore Chinese Eye Study, 2009-2011. AMD was graded from retinal photographs using the Wisconsin Age-Related Maculopathy Grading System.…”

Section: Methodsmentioning

confidence: 99%

Urinary Isoprostane Levels and Age-Related Macular Degeneration

Sabanayagam

Lye

Januszewski

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Oxidative stress, characterized by an excessive production of reactive oxygen intermediates has been suggested to play a role in the pathogenesis of age-related macular degeneration (AMD). We examined the association of urinary F2-isoprostanes (F2-IsoPs), a marker of lipid peroxidation and the most reliable marker of oxidative damage with AMD. METHODS.We included 238 adults with AMD and 390 age-and sex-matched controls without AMD who participated in a population-based cross-sectional study in Singapore (Singapore Chinese Eye Study, 2009-2011. AMD was graded from retinal photographs using the Wisconsin Age-Related Maculopathy Grading System. Urinary-free F2-IsoPs (pmol/mmol of creatinine) were measured by gas chromatography mass spectrometry (GC-MS). The association between F2-IsoPs and AMD was examined using unconditional logistic regression models adjusted for potential confounders including smoking, body mass index (BMI), blood pressure, total and high-density lipoprotein cholesterol, and history of cardiovascular disease. RESULTS.Higher levels of F2-IsoPs were associated with AMD independent of potential confounders. Compared to quartile 1 (Q1) of F2-IsoPs, the multivariable odds ratio (95% confidence interval) of AMD in quartiles 2, 3, and 4 were 2.05 (1.26-3.32), 1.80 (1.10-2.94), and 1.76 (1.06-2.94), respectively. In subgroup analyses comparing Q4 to Q1, this association was stronger in women, those with BMI less than 25 kg/m 2 and those with hypertension, but no significant interaction was found (P interaction > 0.1 for each strata).CONCLUSIONS. Higher levels of urinary F2-IsoPs levels were associated with AMD independent of potential confounders in Chinese adults.Keywords: age-related macular degeneration, Asians, isoprostane, oxidative stress A ge-related macular degeneration (AMD) is a leading cause of irreversible blindness in older adults worldwide.1,2 Globally, 170 million adults have AMD, exerting a significant socioeconomic burden on healthcare systems.2,3 Despite significant research over decades, the pathogenesis of AMD is still not clear, and robust systemic biomarkers of AMD have not been identified yet. 4 Oxidative stress, characterized by an imbalance between excessive generation of reactive oxygen species (ROS) and their degradation by antioxidants, has recently been proposed to play a significant role in the pathogenesis of AMD. [5][6][7] With advancing age, the retina becomes more susceptible to oxidative stress and damage to the retinal pigment epithelium (RPE) occurs early in the natural history of AMD.8 At physiological concentrations, ROS are involved in cell signaling and regulation of immune responses. 9 However, disproportionate levels of ROS with concurrent impairment of enzymatic and nonenzymatic antioxidants damage cellular proteins, membrane lipids, and DNA that eventually lead to tissue injury, cellular death 10 resulting in accumulation of detrimental products including intracellular lipofuscin, and extracellular drusen. 6Oxidation of membrane lipids or lipid pero...

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“…Its circulating plasma levels have been associated with colon, prostate, and breast cancer [23], [24], [25], hence its association with malignant processes. To our knowledge, however, 8-Iso-PGF2 (8IP) has not been measured in BE or EAC tissue samples.…”

Section: Introductionmentioning

confidence: 99%

Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett’s Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction

Kauppi

Räsänen

Sihvo

et al. 2016

Translational Oncology

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OBJECTIVES: Oxidative stress (OS) is an essential element in the pathogenesis of Barrett’s esophagus (BE) and its transformation to adenocarcinoma (EAC). The state of OS in the proximal stomach of patients with BE and EAC is unknown. Isoprostanes are a specific marker of OS not previously used to determine OS from BE/EAC tissue samples. PATIENTS AND METHODS: OS was measured in 42 patients with BE (n = 9), EAC (n = 9), or both (n = 24) and 15 control patients. A STAT-8-Isoprostane EIA Kit served to identify 8-Isoprostanes (8-IP), and a Glutathione Assay Kit was used to measure glutathione reduced form (GSH) and glutathione oxidized form. An OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG) served to measure 8-OH-deoxyguanosine. RESULTS: The 8-IP (P = .039) and 8-OHdG (P = .008) levels were higher, and the GSH level lower (P = .031), in the proximal stomach of the study group than in that of the controls. Helicobacter pylori infection was present in 8% of the study patients. CONCLUSIONS: In the proximal stomach of BE and EAC patients, OS was elevated and antioxidative capacity was reduced. This finding suggests that the gastroesophageal reflux causing BE also induces oxidative stress in the proximal stomach and may contribute to the development of cancer in the proximal stomach and gastric cardia.

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Oxidative Stress Measured by Urine F2-Isoprostane Level is Associated With Prostate Cancer

Abstract: Background-Oxidative stress is implicated in prostate cancer (PCa) by several lines of evidence. We studied the relationship between the level of F2-Isoprostanes (F2IP), a validated biomarker of oxidative stress, and PCa and high-grade prostatic intraepithelial neoplasia (HGPIN).

Cited by 76 publications

References 30 publications

Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study

Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study

Urinary Isoprostane Levels and Age-Related Macular Degeneration

Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett’s Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction

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