Oxidative Stress Markers in Young Patients with Polycystic Ovary Syndrome, The Relationship between Insulin Resistances

Abstract

In our study, because those participants were young and non- obese patients with PCOS, malondialdehyde, nitric oxide and disulfide levels and Carotid Artery Intima-Media Thickness measurements as a pre-indicator of cardiovascular disease were not found to be different from those of the controls.

Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome

“…This mechanism may at least partly explain our observation of significantly decreased serum 8-OHdG levels among subjects with PCOS. In line with this hypothesis, several investigators have recently reported that major antioxidant enzymes are significantly induced in subjects with PCOS compared with healthy subjects (16,17,19). Additionally, inactive DNA repair enzymes may also lie behind lower serum 8-OHdG levels in subjects with PCOS.…”

“…Earlier studies concerning the oxidative stress balance in women with PCOS compared with healthy control women have involved the use of relatively unspecific methods (e.g., malondialdehyde (MDA), glycosylated end products, and protein carbonyls) (13)(14)(15)(16)(17)(18). Most of these studies, but not all (16), have shown increased oxidative stress in women with PCOS.…”

Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

“…While, IR is not a disease, it is associated with increased risk of T2D and cardiovascular morbidity and mortality. Studies demonstrate that there is an association between PCOS and IR however, IR in PCOS is found to have no effect on the concentration of MDA which is a biomarker of OS [20]. Compromised insulin secretion facilitates excess androgen secretion from ovaries and adrenals in PCOS patients.…”

“…Lipid peroxidation process revealing malonyldialdehyde (MDA) is accepted to reflect OS [20], while SOD, an antioxidant enzyme, serves as a defensive mechanism of the body. Intracellular and cell wall damage due to increased ROS leads to an increase in MDA levels.…”

The Influence of Oxidative Stress in Inflammatory Process and Insulin Resistance in Obese Women with Polycystic Ovary Syndrome

“…This is because the adipose tissue is an endocrine organ able to secrete various substances which interfere with the metabolism of carbohydrates and lipids, and it is also involved in innate and adaptive immune response by producing cytokines such as tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), as well as acute phase protein, such as the C-reactive protein (CRP), which contribute to the establishment of insulin resistance, of systemic inflammatory status and of other cardiometabolic risk factors in the long term [10][11][12]. In association with inflammation, the oxidative stress, which is a condition resulting in excessive formation of oxidizing species in the presence of limited antioxidant defenses [8,9,13], culminating in the formation and removal of ROSs in the body [14], can also contribute to the worsening of metabolic disorders of the syndrome [15].…”