Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome

Sova, Henri; Morin‐Papunen, Laure; Puistola, Ulla; Karihtala, Peeter

doi:10.1016/j.fertnstert.2010.03.049

Cited by 22 publications

(23 citation statements)

References 25 publications

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“…However, in contrast to Ang-1, no differences were noted in serum Ang-2 levels between PCOS and non-PCOS women. Our data are consistent with a previous report that did not find a difference in serum Ang-2 levels between unstimulated PCOS and matched non-PCOS women [19]. Elevated serum Ang-1 in PCOS in our study is also consistent with several previous reports indicating increased angiogenesis in PCOS women.…”

Section: Discussionsupporting

confidence: 94%

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Angiopoietin-1 and angiopoietin-2 are altered in polycystic ovarian syndrome (PCOS) during controlled ovarian stimulation

Tal¹,

Seifer²,

Grazi³

et al. 2013

Vasc Cell

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Polycystic ovarian syndrome (PCOS) ovaries are characterized by increased angiogenesis and hypervascularity. While angiopoietin-1 (Ang-1) and its antagonist, angiopoietin-2 (Ang-2), are essential for ovarian function and angiogenesis, the levels of Ang-1 and Ang-2 in PCOS are unknown. This was a prospective cohort study of 14 PCOS women and 14 matched controls undergoing controlled ovarian stimulation (COS). Serum was collected on day 3, hCG and retrieval days. Follicular fluid (FF) was collected on retrieval day. Serum Ang-1 and Ang-2 levels were constant throughout COS, but serum Ang-1 levels were increased at all time points in PCOS women compared with controls (p < 0.05). No differences between groups were found in serum Ang-2 levels or FF Ang-1 levels. However, FF Ang-2 levels were increased almost 2-fold in PCOS women compared with controls (p < 0.01), and correlated positively with number of oocytes retrieved (r = 0.65, p < 0.0001). This study is the first to provide evidence of an alteration in the Ang-1/Ang-2 system in PCOS women. The biological role of Ang-2 in promoting capillary leakage, the increased Ang-2 FF level in PCOS, and its correlation with number of oocytes suggest that Ang-2 may play an important role in the increased risk of ovarian hyperstimulation in PCOS.

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Section: Discussionsupporting

confidence: 94%

“…In addition, serum Ang-2 levels in non-stimulated women were not found to be different between PCOS and matched controls [19]. However, despite evidence suggesting an important role for angiopoietins in ovarian angiogenesis, their levels and dynamics have not been previously investigated in PCOS during controlled ovarian stimulation.…”

Section: Introductionmentioning

confidence: 99%

Angiopoietin-1 and angiopoietin-2 are altered in polycystic ovarian syndrome (PCOS) during controlled ovarian stimulation

Tal¹,

Seifer²,

Grazi³

et al. 2013

Vasc Cell

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“…Although there are many studies in which local and systemic 8‐OHdG, MDA, and TAS levels have been researched in systemically healthy individuals with periodontitis, the study by Dursun et al . is the only one to have evaluated PCOS and CP.…”

Section: Discussionmentioning

confidence: 99%

“…Sample size was specified by using a power analysis of the serum 8‐OHdG, which had the greatest variation among all the groups (PCOSCP, CP, PCOSPH, and PH). To detect a significant difference at an effect size of 0.61 and power level of 80% with a 95% confidence level, at least 18 patients were required for each group . In this study, 22 participants were included in each group to allow for dropouts.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of oxidative status in patients with chronic periodontitis and polycystic ovary syndrome: A cross‐sectional study

Sağlam

Çanakçı

Şebin

et al. 2018

Journal of Periodontology

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“…Some studies put forward that the reason of increased oxidative stress may depend on metabolic and reproductive anomalies related to PCOS (23) .…”

Section: Discussionmentioning

confidence: 99%

The measurement of urinary 8-hidroxy-2'deoxyguanosine level with liquid chromatography-tandem mass spectrometry method in patients with polycystic ovary syndrome

Özdemir¹,

Özdemir²,

Sezer³

et al. 2014

J Turk Soc Obstet Gynecol

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SUMMARY Objective:The measurement of urinary Material and methods: Twenty-eight patients with PCOS diagnosis according to the criteria of 2003 Rotterdam Concensus Conference on PCOS were included in this study and twenty-seven healthy women were included as control group. After collecting first morning urine samples of patients and women in control group, the urinary 8-OHdG level were measured by LC-MS/MS method and the results were expressed as nmol/L. 8-OHdG/creatinine ratio (nmol/mol) was used to compensate the variation of all nucleoside concentration in urine. The patients with PCOS and the

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Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome

Cited by 22 publications

References 25 publications

Angiopoietin-1 and angiopoietin-2 are altered in polycystic ovarian syndrome (PCOS) during controlled ovarian stimulation

Angiopoietin-1 and angiopoietin-2 are altered in polycystic ovarian syndrome (PCOS) during controlled ovarian stimulation

Evaluation of oxidative status in patients with chronic periodontitis and polycystic ovary syndrome: A cross‐sectional study

The measurement of urinary 8-hidroxy-2'deoxyguanosine level with liquid chromatography-tandem mass spectrometry method in patients with polycystic ovary syndrome

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