Oxidative stress markers in saliva and plasma differ between diet-controlled and insulin-controlled gestational diabetes mellitus

Zygula, Aleksandra; Kosiński, Przemysław; Zwierzchowska, Aneta; Sochacka, Małgorzata; Wroczyński, Piotr; Makarewicz‐Wujec, Magdalena; Pietrzak, Bronisława; Wielgoś, Mirosław; Rzentala, Mateusz; Giebułtowicz, Joanna

doi:10.1016/j.diabres.2018.11.021

Cited by 31 publications

(28 citation statements)

References 39 publications

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“…However, regarding lipid peroxidation markers (MDA), we observed no correlation in saliva and plasma. Similar results were observed previously among gestational diabetic patients [78] and it was concluded that the concentration of MDA in saliva is strongly dependent on the oxidative balance of saliva and the state of the oral cavity. However, in some pathologies related to strong oxidative stress, such correlation was observed.…”

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confidence: 89%

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Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Zygula

Kosiński

Wroczyński

et al. 2020

Oxidative Medicine and Cellular Longevity

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Aim. Pregnancy-induced hypertension (PIH) and intrauterine growth restriction (IUGR) are both multisystemic disorders of pregnancy that cause perinatal morbidity and mortality. Recently, researchers focused on the role of oxidative stress (OS) as a pathophysiological mechanism in the development of these pathologies. The aim of this study was to compare OS in placental-related pathologies (PIH and IUGR) and uncomplicated pregnancies. We also investigated which salivary OS markers reflect systemic oxidative status and which only reflect the state of the oral cavity. Material and Methods. A total of 104 pregnant women (n=104; 27 with PIH, 30 with IUGR, and 47 controls) were evaluated. Malondialdehyde (MDA), total antioxidant capacity (ORAC), aldehyde dehydrogenase (ALDH), and activity of glutathione peroxidase (GPx) and glutathione transferase (GST) in plasma/whole blood and/or saliva were analysed. Dietary nutrient intake was calculated using a Semiquantitative Food Frequency Questionnaire (SFFQ). Oral health was assessed to eliminate patients with bleeding, severe periodontitis, and other dental pathologies. Results. In the IUGR group, increased concentration of ORAC was observed both in saliva and plasma. Also, lower plasma levels of MDA in IUGR compared to the control group was detected. No sign of oxidative stress was confirmed in the PIH group. The examined groups did not differ regarding diet and markers of inflammation. ORAC in saliva was correlated with its level in plasma. No such correlations for MDA were observed. In the IUGR group, there were no differences in OS markers in plasma, but there was a lower ALDH level in the blood compared to the control group. It confirms OS occurrence in IUGR. In IUGR, a higher activity of salivary ALDH was probably due to worse oral health. Conclusion. Oxidative stress differs between IUGR and PIH groups: the presence of oxidative stress was confirmed only in the IUGR group. Salivary ORAC can be used to estimate ORAC in plasma. The activity of salivary ALDH reflects the state of the oral cavity.

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confidence: 89%

“…In our study, a significant correlation between ORAC in saliva and plasma was observed. Similar results were previously obtained for patients with gestational diabetes [78]. Saliva was also considered valuable for estimating the variation of total antioxidants in plasma of triathletes during the training season [79].…”

supporting

confidence: 78%

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Zygula

Kosiński

Wroczyński

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Therefore, further researches are necessary for this area, since the salivary biomarkers seem to be a promising diagnostic material, because it is easily accessible and non-expensive. Furthermore, salivary redox biomarkers are used in the diagnosis of metabolic diseases [19][20][21][22][23][24][117][118][119][120][121] or cancer [122].…”

Section: Summary and Perspectivementioning

confidence: 99%

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Maciejczyk

Gerreth

2020

JCM

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Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, are disorders, which cause irreversible and progressive deterioration of the central nervous system. The pathophysiology of NDDs is still not fully explained; nevertheless, oxidative stress is considered as a critical mediator of cerebral degeneration, brain inflammation, as well as neuronal apoptosis. Therefore, it is not surprising that redox biomarkers are increasingly used in the diagnosis of neurodegenerative diseases. As saliva is a very easy to obtain bioliquid, it seems promising to use this biomaterial in the diagnosis of NDDs. Saliva collection is easy, cheap, stress-free, and non-infectious, and it does not require the help of a specialised medical personnel. Additionally, the concentrations of many salivary redox biomarkers correlate with their content in blood serum as well as the degree of disease progression, which makes them non-invasive indicators of NDDs. This paper reviews the latest knowledge concerning the use of salivary redox biomarkers in the diagnosis and prognosis of selected neurodegenerative diseases.

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“…In order to evaluate the redox balance and inflammatory response, the use of the saliva is a powerful and noninvasive tool linked not only with oral hygiene and buccal disorders but also with the general health state of humans [20,21] . Furthermore, the evaluation of redox/inflammatory biomarkers in saliva was proposed as an accurate diagnosis for the development and progress of many oxidative stressmediated diseases, such as diabetes [22], rheumatoid arthritis [23], chronic renal failure [24], obesity [25], and many neurodegenerative disorders [26]. Not surprisingly, the impairment of such important salivary enzymes could drastically hamper energy metabolism and both oral and gastrointestinal microbiota functions, increasing the risk of infectious diseases [27].…”

Section: Introductionmentioning

confidence: 99%

L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals

Almeida

Santos

Paixão

et al. 2020

Oxidative Medicine and Cellular Longevity

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Although regular combined aerobic-resistance exercises can ameliorate the inflammatory status and redox balance in elderly population, it is unclear whether protein or specific amino acid supplementation could improve such benefits. Therefore, we aimed to evaluate the inflammatory status and redox indexes through of the saliva of 34 elderly subject nonpractitioners (NP group, 73.3±6.6 years) and 49 elderly subject practitioners of a combined-exercise training in moderate intensity (CET group, 71.9±5.8 years) before (pre) and after (post) 30 days of supplementation with L-glutamine (Gln) or placebo (PL). Our results showed that, both in pre- and postsupplementation, the salivary levels of nitric oxide (NO⋅) and TNF-α were lower, whereas the levels of uric acid and IL-10 (as well as IL-10/TNF-α ratio) were higher in the CET groups than in the NP groups. In postsupplementation, both groups supplemented with Gln (NP-Gln and CET-Gln) showed higher salivary uric acid levels compared to baseline. In addition, lower NO⋅ levels were found in the CET-Gln group postsupplementation than presupplementation values. Whereas the CET-Gln group showed lower GSH levels postsupplementation, NP-Gln subjects showed lower GSSG levels at the same time point, both compared to baseline. Interestingly, salivary peroxidase activity was lower only in NP groups (NP-PL and NP-Gln) postsupplementation than baseline values. A positive significant correlation between salivary peroxidase activity and GSH levels, and also between salivary peroxidase activity and uric acid levels were observed in the CET-Gln group both pre- and postsupplementation. No differences were found in albumin, total antioxidant activity (TEAC), and reducing power analysis between groups, pre- or postsupplementation. In conclusion, the elderly subjects from the CET group showed a better inflammatory response and redox balance and, for the first time, it was shown that daily supplementation with Gln for 30 days can improve these benefits with putative association with a healthy aging.

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Oxidative stress markers in saliva and plasma differ between diet-controlled and insulin-controlled gestational diabetes mellitus

Cited by 31 publications

References 39 publications

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals

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